Basic Information

Gene Symbol
-
Assembly
GCA_000006295.1
Location
NW:71592-74413[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.4 27 4.8 1.1 1 23 101 123 101 123 0.95
2 13 0.12 8 6.4 0.3 1 23 309 332 309 332 0.93
3 13 0.11 7.4 6.6 2.1 2 21 366 384 365 385 0.92
4 13 1.5 98 3.0 3.5 3 23 401 420 400 420 0.81
5 13 0.0015 0.1 12.4 0.2 3 23 428 448 426 448 0.92
6 13 1.6 1e+02 2.9 1.4 3 23 456 475 455 480 0.73
7 13 6.7e-07 4.5e-05 23.0 0.6 1 23 480 502 480 502 0.97
8 13 0.17 11 6.0 1.9 3 23 521 542 520 542 0.95
9 13 2.1e-05 0.0014 18.3 0.4 1 23 553 576 553 576 0.96
10 13 0.00018 0.012 15.4 0.4 2 23 596 618 595 618 0.95
11 13 2.3e-06 0.00015 21.3 1.0 2 23 631 653 630 653 0.94
12 13 0.0013 0.085 12.7 2.0 2 23 660 681 659 681 0.97
13 13 9.4e-05 0.0063 16.2 3.1 1 23 687 709 687 709 0.98

Sequence Information

Coding Sequence
atggaaaatgtaattaaaatatcatGTAGATTATGCGACGAAGatatacgaaataaaaatggttaTTTGTTGTatgattataatgataatgcagaaacaaaaattggaagaaaattaaatattattttacattctaATGAAAAATTTGAAGATTTATCTAATTACTGTTGCGATTATTGTTATTCTAAAATTGAAATGTGTTTCGGATTATTGGTAGACATAAGAGCATCAGATGAAATAATTCaacaaacttatttaaattcttcagaaaaagaaaatcttgaTACATCAAATCAATTATTCATTTGTTCAGAATGTAATGTTACAATATCaggaattaaattattcacaAAACATCATGaaaatcatataaaaaaaaaaacgatagcaGGTTCTAAAAAAGATATCCCACTTTCatctgttttatttttaaaagatggagaaaatgataaaaatgaatttacttATGAAAAACATGGAAATGATGAAAcatgtttaatatttaatgaaaatgaagaTGAAATCCATCGATACAACAATTTCTTTGagaataatataaaagaagaaaattatgaagaaaatatttataaaaaaaatgaatttgttaataataataatttaaataatagtgaaaaatttgaacttagaaaatttaatttatcgccTAAACaaatcaatgatgatgatactacAATTTTAAGTTTTGATTCTTCTGAAGAATatttagaaaatgataatgatgtcaatttaacaaatgaaaaagacTTTGATGAACAAGATTCTTATTTTTCCGATGCCTTATCCGAAGATTCAAATTCGAGTCAATcaagttataaaaatttggttGAAATCGTTAAATGGGAATTGGAAAAGTCGGATAGTGAggataatgatttaaaaatagaacCTAATCAGGatggaaaatattattgtGATGTTTGTAATTTGGAAtttgaatataaatttattcttgCTCTTCATTTGAAAGAAAATCACAAAGTTTTTCACGAGTTTTTTGACATAAATGCTCAAGAGAAACAAAcatttgaaacattttttgaagatgatgatgatgatgatgatgatatattaCAAAAATGTTGTTATTGTAAGAAAACATTAACATCATCTGAATTCAATTCTCATATTTTAGAATGTAAAGGAGAatattctttaaataataataataaaaatgttctCTGTCAAATTTGTGGGAAAATGTGCTGCGTTAAAAGTTTAGAAAAACATATGGaagaacataaaaaattagatggTTGGGCATGCGAATTATGTGGGAAAAAGTTCAAAGCTAAAAGATTTTTAGAGAGTCATTTGGGAGAACACGatgaaagtaaaaagaaaatctgtgAAATTTGTGGTAAAAAACTGCTGCCACTTTCGTTTTTCAGTCACATTACAAAGCATAGGAAAAAACGTCACATATGTCAATACTGCGGTAAAGCTTTTAGCTACAGTTACGGATTGCGAATACATTTGAAAGTACACGACAATAGTAAAAAATTAGAGCCCAaaccggagaaaaaaaaggacaaagtTTTTTGTTGGCTTTGCAAGAAAGATTTCAGTTGTGCAATCGCATTGaataaacatttgaaaaacgaTCATAATGCAGAAGGCGTCGAACAAGATTCTCGATTTCCCTGTTCTCAGTGcgataaaaaatttgccgACATGTTTTCGTTGAAAGCTCATCTTAAATTGATACACGAAATGAAAGATGAGGAAATAGCACGTTTGAAATCATTGCCGGtgtatcgatatatcgaatgcAACGTTTGCAATAAAGTTTTCAATAgcgaaaacaaaataagaatTCACATGAAACAGGATCACGGTTTGAAACCTTTCGAAATGGAAATATTGAAAAAGGAATGCGAGAAATGTGGTAAAAAATTTGCTagcaaacaaaatttaattcatcatATAAACGGAGCTCACCTTCACATCAAACCTATGACCTGCGACATTTGTCaggaaaaatttgcaaaacatTCTTCTTTGATTTATCATAAATTGAGACATTCTGgtgaaaaaccttttcaatGCGAGTTTTGCCATAAATCTTATAGACAGAGAAACGACGTCATTAGACATTTGGCAAGGCACGTACGCGATAAAGAACTTACTTTAGAAGAAGCTTCTGCTGTAAATAATAGTCCTTCTCGACTGGTGATCAAAagaagaatatttttaaaagattcgAGCATAAATTACAGAACCATATTTCGTAAAAATCGGCGAAAATCCGAAGTCATGGAAATGGAACCCATTTTGGAAGAAGAAGTTAGTGAGATTCAAGAAGAGCAAATGGAATTTAACGAAGATGGAATTTCAGATATGATTTACGTGGAAGAGGTTCAATTGGAAGAAAATCAACCTGAAAGCCCACTGGAGGTTCAGTGCATGAACGTGAAACCTGTGTACAATGAAGAAAGGAATAccataattttatcaaatccTGTGAAAAACGTTTCTTGTAAATACATGCCATCTCAAATCAAACACATACCGGCCGTCATAGTTAAAAAACAAGAACAGATTCAgttaccttaa
Protein Sequence
MENVIKISCRLCDEDIRNKNGYLLYDYNDNAETKIGRKLNIILHSNEKFEDLSNYCCDYCYSKIEMCFGLLVDIRASDEIIQQTYLNSSEKENLDTSNQLFICSECNVTISGIKLFTKHHENHIKKKTIAGSKKDIPLSSVLFLKDGENDKNEFTYEKHGNDETCLIFNENEDEIHRYNNFFENNIKEENYEENIYKKNEFVNNNNLNNSEKFELRKFNLSPKQINDDDTTILSFDSSEEYLENDNDVNLTNEKDFDEQDSYFSDALSEDSNSSQSSYKNLVEIVKWELEKSDSEDNDLKIEPNQDGKYYCDVCNLEFEYKFILALHLKENHKVFHEFFDINAQEKQTFETFFEDDDDDDDDILQKCCYCKKTLTSSEFNSHILECKGEYSLNNNNKNVLCQICGKMCCVKSLEKHMEEHKKLDGWACELCGKKFKAKRFLESHLGEHDESKKKICEICGKKLLPLSFFSHITKHRKKRHICQYCGKAFSYSYGLRIHLKVHDNSKKLEPKPEKKKDKVFCWLCKKDFSCAIALNKHLKNDHNAEGVEQDSRFPCSQCDKKFADMFSLKAHLKLIHEMKDEEIARLKSLPVYRYIECNVCNKVFNSENKIRIHMKQDHGLKPFEMEILKKECEKCGKKFASKQNLIHHINGAHLHIKPMTCDICQEKFAKHSSLIYHKLRHSGEKPFQCEFCHKSYRQRNDVIRHLARHVRDKELTLEEASAVNNSPSRLVIKRRIFLKDSSINYRTIFRKNRRKSEVMEMEPILEEEVSEIQEEQMEFNEDGISDMIYVEEVQLEENQPESPLEVQCMNVKPVYNEERNTIILSNPVKNVSCKYMPSQIKHIPAVIVKKQEQIQLP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-