Basic Information

Gene Symbol
-
Assembly
None
Location
scaffold296:23084-26222[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.6 24 5.2 2.2 1 13 229 241 229 252 0.77
2 13 0.0084 0.34 11.1 0.2 2 20 266 284 265 286 0.91
3 13 2 80 3.6 1.5 2 23 298 320 297 320 0.90
4 13 0.29 12 6.2 0.3 3 22 361 380 359 380 0.93
5 13 0.0062 0.25 11.5 0.1 1 20 389 408 389 410 0.95
6 13 0.001 0.04 14.0 0.3 2 21 508 527 507 528 0.92
7 13 0.0011 0.044 13.9 0.4 1 19 576 594 576 596 0.94
8 13 0.013 0.53 10.5 0.5 1 23 607 630 607 630 0.90
9 13 0.046 1.8 8.8 0.4 1 22 669 690 669 690 0.96
10 13 0.00015 0.0061 16.6 0.8 3 21 699 717 697 718 0.95
11 13 0.0018 0.074 13.2 1.3 3 23 725 745 723 745 0.96
12 13 0.00019 0.0076 16.3 3.3 1 23 751 773 751 773 0.97
13 13 0.45 18 5.7 3.7 2 23 780 802 779 802 0.93

Sequence Information

Coding Sequence
ATGATGGCACAATGTAGAGTTTGTGCATCTATTGAAAGTGCTGAATATTTTCAAATATTCCAAAAAGCTGGAAATTTGGAGAAAATCTTATATTCWTGCTTACAAATTGAGGTTTCTCAAGAGACAGAACCAGATGCTAAAGTCTGTTCAGAATGTGAGGTACATCTTAGGACCACCTATGAAATGAAATTAAGAGCAATCGCTTTGGATGAGATTTTCCAAGAAAATGACACAATCAATAGCCTATCTAGAGTGGTTCAAACATACTTAAATGAGCGCAGAAAAGTAAATTTCAGTCTAGAGAAGTTACCAGGACAATTGAAAATTACCGAACTAAGCCTATGCGTAAAAATTGAAGCTGAAGAACTGGCAGAGCATTTAGAAAATTCTGAAAATTTGCAGCACATTTTGGACCCGTTTTGTTATGAGGAAAATAAAGAAGATGCCACAMYTTTCAAGTATGAGCCAGAAGTATTAGATGCAGCTGTTACAATTAAGGATGAAGATTAYGCKTGTAGCAGTCAATTCTCTAGCAGTGATTCTGATTTTCTGGTGACATTAAAAAAGATCAGAAGCAAAAAACAAGTAAAGAAAACTTCGAGTACACAAAATAAAACAGACAAGAAGACCAAGCTTTCCAAAAAGTTTAAAACAATTGGCAGCCCACTGCCTGGTAGCTCTAAATTCTACTGTTTTTACTGCAAAAAAGACTTCAAAAGTAACCGCATCTTGTTCATTAATCACACTAATGTRCATACCACATTCAAGTTCATTATGAATGAAATGAAGCTGATTACATGTTCAAAATGCACAAAAATGTTCAAATCAGACGCAGACTTGGCGTCCCACTCACTRACCACTTGCAAACCTCCAACAAAGAAATCAAAAATTCCTTGTCACTACTGCAATGAAAAGCAAGAAACGGTWGAMAAATTGAAAGAACACATGATTTTCAAGCATTGCGATCAGTTGTCTTGTCCWRTAGGTACTTGTCAAGTGCAAAGATTAGGATACTCAAAGCTGTACCATCATATTAGAGTCCATCACCCAGCTGATATTAAAACTAACAATGAACTTTTTTGCACTTACTGCAACGATCAATTCATCACGATCAAAGAGTTGGAATCTCACCGTATGACTGACAACAACTGCATCGGAAAACGATTCACTTGTCCTGATTGTGGAGATAAATTTGGAGACAGTAGACTGATGAATAAACATATTGTGAAAGAAAATGAGCTGAAGGAGTTYRCAGSYACCACAGGTGAAGATCGAGCCAGTATTATTGAAGAAAATAAAATCAAAGATGCTATCTTGAAATCTCATACCTGCCCACGATGTGGAAAGAAGCTTGGATGCCTGCAATCCTTGAAATACCATTGTAGACTCTGTTGTCCAGATTCAATCATTTTTAAGACGACCAAAAATACTTTCTATTGCGACATTTGTGAGAAAATTTCAAACTGCACTAGCATCGGAGGTTTTAGAAAACACCAAGAAGCCTGCAAACTTATCATTATTTCATGTCGCATTTGCTCGGAGAAATTTGAGAACAATTCTGAGCTGAAAAAACATTCGAAGATTTGTTATCCTCAACCAAGTACAAACCCTAAATGTCTTTTTTGCGATAAAGTGTTCCACGGTGAAAAGTTATCGCTTTATCGTCATCATTTGAGCATGCATGTCGCCTTCAAATTTTTATTTGAGAAGAATTACCTGGCTTTTCACGATTGTTCTAATTGTAACAAGACTTTCTCAACTGAAGAGTTGTTGGCCCAACATGGTGAAGAATGCAATTCAGTTGTTGAAGAAAATGTACATCCTTGCGGTGATTGTGACGCAGTTTATGAATCAGCAAATACTTTGAAGGAACATCAATTTTTCAAACATTTTACTTACTTTGTGTGTCCTGTATCAAATTGCAAGTCCTCTTATACTAAATACGGACCATTCTATTTCCATATGGTTGGAGCCCACGTTGGATTCATTGAGCCCATTAAAGAGTTTCAATGTGTGTATTGCAATATGCTCTTCACATCATTCCCATTGTTAGATACACATCTTCGCAAACAATGTTCTGGAAAAACCATTGATTGCACTCATTGCGATAAGAAGTTTGGAAATATAAAGACTTTGAAGAATCACATGCGAGCWGTAAAAAATCCAGTCATATGTGATGACTGCGGAAAAGCGTGCTTCTCCAAAAATGATCTGGTCATGCATAAAAGATTTCACACAGGCGAAAAACCTCATGTKTGCAACGTTTGTCAAAAACGATTTGCTACTTCTTCGTCTCGAAATACTCACTTAAAGTCCCACATGGTTGATCGAGTACTTCCGTGCGATAAATGTAATTACATGGGTCAAAGTTCAGTACATCTCAATAAACATAAGAAGGATTGCCATTCTGGAAAATACTGCTGTCCATTATGTTCCTCTGTCTTGAGCTGCATAAGATCAATTGAAACGCATCTCAAAATCATGCACCAGCTAACTCCAGAAAACATCAAGAAAATTAAAAAACAGTGCCATTAA
Protein Sequence
MMAQCRVCASIESAEYFQIFQKAGNLEKILYSCLQIEVSQETEPDAKVCSECEVHLRTTYEMKLRAIALDEIFQENDTINSLSRVVQTYLNERRKVNFSLEKLPGQLKITELSLCVKIEAEELAEHLENSENLQHILDPFCYEENKEDATXFKYEPEVLDAAVTIKDEDYACSSQFSSSDSDFLVTLKKIRSKKQVKKTSSTQNKTDKKTKLSKKFKTIGSPLPGSSKFYCFYCKKDFKSNRILFINHTNVHTTFKFIMNEMKLITCSKCTKMFKSDADLASHSLTTCKPPTKKSKIPCHYCNEKQETVXKLKEHMIFKHCDQLSCPXGTCQVQRLGYSKLYHHIRVHHPADIKTNNELFCTYCNDQFITIKELESHRMTDNNCIGKRFTCPDCGDKFGDSRLMNKHIVKENELKEFXXTTGEDRASIIEENKIKDAILKSHTCPRCGKKLGCLQSLKYHCRLCCPDSIIFKTTKNTFYCDICEKISNCTSIGGFRKHQEACKLIIISCRICSEKFENNSELKKHSKICYPQPSTNPKCLFCDKVFHGEKLSLYRHHLSMHVAFKFLFEKNYLAFHDCSNCNKTFSTEELLAQHGEECNSVVEENVHPCGDCDAVYESANTLKEHQFFKHFTYFVCPVSNCKSSYTKYGPFYFHMVGAHVGFIEPIKEFQCVYCNMLFTSFPLLDTHLRKQCSGKTIDCTHCDKKFGNIKTLKNHMRAVKNPVICDDCGKACFSKNDLVMHKRFHTGEKPHVCNVCQKRFATSSSRNTHLKSHMVDRVLPCDKCNYMGQSSVHLNKHKKDCHSGKYCCPLCSSVLSCIRSIETHLKIMHQLTPENIKKIKKQCH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-