Basic Information

Gene Symbol
ZNF217
Assembly
None
Location
scaffold564:58306-60247[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.032 1.3 9.2 0.5 3 23 67 88 66 88 0.92
2 13 3.1e-05 0.0013 18.7 2.8 1 23 120 142 120 142 0.98
3 13 0.00013 0.0054 16.7 0.8 1 23 146 169 146 169 0.95
4 13 0.00017 0.0066 16.5 1.1 1 23 176 199 176 199 0.96
5 13 0.0005 0.02 14.9 0.2 3 23 244 265 243 265 0.96
6 13 0.0049 0.2 11.8 0.9 2 23 270 291 270 291 0.98
7 13 0.00044 0.018 15.1 0.3 1 23 297 319 297 319 0.95
8 13 0.0011 0.045 13.8 3.4 1 23 324 347 324 347 0.96
9 13 0.038 1.5 9.0 0.5 3 23 355 376 354 376 0.95
10 13 0.17 6.6 7.0 1.0 2 23 383 404 382 405 0.90
11 13 9.4e-05 0.0037 17.2 2.7 2 23 420 441 419 441 0.97
12 13 0.0075 0.3 11.2 6.7 1 23 460 482 460 482 0.98
13 13 0.0017 0.068 13.3 0.6 1 23 488 511 488 511 0.97

Sequence Information

Coding Sequence
ATGGAGAGCACAGCAGAATTARTCATCGTCAAAAATGAAAATGTARTTTGCGAGATTCCGAAAGTGAACAACAGCACCAAAAWTAGTGGAAAATCTCAAAAAAGCAAAAAAYCGCAGACCAAAACTAAAGCTGTTAGAGTACCTAGAAAAGGGAGACCATTAAATCCTTCAGCGACTGAACGTTTTGCCAAGCGAGCCTGTGCTATTTGCAATACAGAATGYATCAACAGTATGGARCTCAATAAGCACTGGCTAGARKTTCACAMCAATGATCGRAAATGCACAGTGTGCTGTATCGAAATGACTTCAGCTAAGAGTCTCCACCAACATATGGTTAAGCATAATCAAGGAAGACCTTATCCTTGTAGAAAATGTGATAAGAAYTTTGCCAGTCAACATACATTRGAATCTCATAARCTGACGCATAAATCTACATATTTTTGTGATTTTTGTACTAAATCTTACACATCCAAATACAGTTTAATTGGACACATTGAAGTTTCTCATCTCAAATCAAAGCAACAATATTCTTGTGATGAGTGTGAAAAGAAGTTTAATCGAAAAAGCGGATATGACATGCATCTCATCTCTAAACATGGTGCTCCGACAAGCGTGATCTGTATAAAGTGTAATATGGGATTCCTGTTCACCTCACAATTAAAGGTGCATGATCGTGAGATCCACCAATATATGAAACCAAAACACACACATTACAACCACGCTAAAATATGTCAAATTTGTAATGAAGAATACGAAACATCTTCTAAATTGGCACAACATATCAAGTATCAGCACGCAAATGATAGAAAGTGTGAAAGGTGCCAAATGACTTTAGGCTCGTCGAAAGAACTTAATCGGCACCTTTTAATGCATGACCGGAAAAAAGTTCATATTTGTCACGTTTGTGGGAAATCAATGAAGTCAGCTGATGCTTTAGTCGCTCATCAAGGAATTCACAAAATAGCAGATTTTTGTTGTGATGTTTGTGGAGTAAAGGTCAAGCAAAAGAAAAGTTTATGCAARCACATCGAGTCTGTACATTTGAAACTTGGTCACGTAGACTGTCCTGATTGYCAAAGCAGGTTCAAATCAGTAGATGCGATGCGKTACCACAGAATCTCTAAACATGATGTTAAACCGCCAATAACTTGTAACCAATGCCAAAAAGGATTTCTGTATATTTCTCAATTAAATGTTCATGAATTTGAACATCATCTTAAAGTKAAGATTCAAAGAAACTACACCAATAACCACAACAAATGTCAAATTTGCAATAGAGTTTTTTGGAGGAGCTCACATCTACAAAAACATCAAGAGTTACACAAACAAGGATATGAATGGGTTAAAAATACAGCCAATGGAGTTAAACCTTTGAAGCATAAGTGCAATTACTGTGCAAAAGCTTTCCATAACAGATGGCTCTTAGATAATCACCACAGATCACATACGGGTGAAAAACCATTCAGATGTGAAATATGTGGGTCTAGATATAATCTCACTAAGACATTAAGAAATCACTTGATAACTGTACATAAGATGATTAAACCAGTAGTCAGTATGAAAACTCATTATTTTCCCGAAGATCCTTCAGAGATTGGGAAACCAAGACACAACTTTTGA
Protein Sequence
MESTAELXIVKNENVXCEIPKVNNSTKXSGKSQKSKKXQTKTKAVRVPRKGRPLNPSATERFAKRACAICNTECINSMELNKHWLEXHXNDRKCTVCCIEMTSAKSLHQHMVKHNQGRPYPCRKCDKNFASQHTLESHKLTHKSTYFCDFCTKSYTSKYSLIGHIEVSHLKSKQQYSCDECEKKFNRKSGYDMHLISKHGAPTSVICIKCNMGFLFTSQLKVHDREIHQYMKPKHTHYNHAKICQICNEEYETSSKLAQHIKYQHANDRKCERCQMTLGSSKELNRHLLMHDRKKVHICHVCGKSMKSADALVAHQGIHKIADFCCDVCGVKVKQKKSLCKHIESVHLKLGHVDCPDCQSRFKSVDAMRYHRISKHDVKPPITCNQCQKGFLYISQLNVHEFEHHLKVKIQRNYTNNHNKCQICNRVFWRSSHLQKHQELHKQGYEWVKNTANGVKPLKHKCNYCAKAFHNRWLLDNHHRSHTGEKPFRCEICGSRYNLTKTLRNHLITVHKMIKPVVSMKTHYFPEDPSEIGKPRHNF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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