Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.082 21 7.8 0.8 1 23 81 104 81 104 0.93

2 7 2.5 6.4e+02 3.1 0.2 2 23 131 153 130 153 0.80

3 7 0.0092 2.3 10.8 1.4 2 23 176 197 175 197 0.97

4 7 0.39 98 5.7 0.1 1 13 201 213 201 214 0.91

5 7 0.00019 0.048 16.1 1.7 1 23 228 251 228 251 0.95

6 7 0.0086 2.2 10.9 0.7 2 23 259 281 258 281 0.87

7 7 0.0013 0.32 13.5 0.6 2 23 289 311 288 311 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.082	21	7.8	0.8	1	23	81	104	81	104	0.93
2	7	2.5	6.4e+02	3.1	0.2	2	23	131	153	130	153	0.80
3	7	0.0092	2.3	10.8	1.4	2	23	176	197	175	197	0.97
4	7	0.39	98	5.7	0.1	1	13	201	213	201	214	0.91
5	7	0.00019	0.048	16.1	1.7	1	23	228	251	228	251	0.95
6	7	0.0086	2.2	10.9	0.7	2	23	259	281	258	281	0.87
7	7	0.0013	0.32	13.5	0.6	2	23	289	311	288	311	0.93

Coding Sequence: ATGTTTCTAGGTCCCCGTTCTCCCGGTATACGTACGAAACCGAAGATAGCTTACATAGAAATATCTGCGGAGCCCCTCACGTTCCAAGAACAGAAAGATGCGGACTTAAAGAGAGAGCAATCACCAGAAATACAGATCTTGCTGAGGAAGAAAAACGAACTGGACCTCCACCTCGATAACCTAAGGGTGATTCTGACGAACTCGAACGCGACTACAATACGCTGCCGCGGTAGCATCGGCTACGTGTGCTGCTTCTGCGACGAGCAGTACCTCGACCCGGCAGACTTGAAACAGCACACGCTCGACACTCATAACGACGTCTTCGAATCGAACTTCATGAAGAGTCAAGCGATGCCGACCCTACTCATCAAACTAGACATAACGAATCTGCACTGCAAAATCTGCAGCAAAGAGGTCTGGGAACTTGAGGACCTTTTGGAACACCTTAAAGATGACCACGGGATCCTCCATCACAGCAATATCAACAGCCACATAGTACCGTTTAGATTCGACAGCCAGACATTGCGCTGCGTTGTCTGCAAGCACATCTTTAACAACTTCAAAGTGCTGCTCGAGCATATGAACATGCACTACAGAAACTATGTCTGTGACGTCTGCGACGCTGGCTTTGTTAATAAGAGAATCTCGCAGATGCACGGTTATCGGCACAAGACCGGCGTCTACCATTGTTCCTACTGCGGGAAAGAGTTCAACAACAGAGTGAAGCAAAGGGCTCACGAAAGGGCGGTCCACGTGTGTCTCAACAAGAGAAGCAAATGCGGGTATTGCGGAGAGAGGTTCTCTGATTATACCAAGAAGCAAGAACATGAGGTCAAGGAACACGGAGCGAAACCACTTGTCCTAACTTGTTACGCGTGTGAGAAGACTTTTGATAATCAACGCACCCTGTCGCTTCACATCAAGGCTTTCCATTTAATGGAGCGTTAG
Protein Sequence: MFLGPRSPGIRTKPKIAYIEISAEPLTFQEQKDADLKREQSPEIQILLRKKNELDLHLDNLRVILTNSNATTIRCRGSIGYVCCFCDEQYLDPADLKQHTLDTHNDVFESNFMKSQAMPTLLIKLDITNLHCKICSKEVWELEDLLEHLKDDHGILHHSNINSHIVPFRFDSQTLRCVVCKHIFNNFKVLLEHMNMHYRNYVCDVCDAGFVNKRISQMHGYRHKTGVYHCSYCGKEFNNRVKQRAHERAVHVCLNKRSKCGYCGERFSDYTKKQEHEVKEHGAKPLVLTCYACEKTFDNQRTLSLHIKAFHLMER

Sequence clustering based on sequence similarity using MMseqs2