Pmne041713.1
Basic Information
- Insect
- Parnassius mnemosyne
- Gene Symbol
- Hr96
- Assembly
- GCA_963668995.1
- Location
- CAVLGL010000090.1:33196536-33232441[-]
Transcription Factor Domain
- TF Family
- THR-like
- Domain
- zf-C4|THR-like
- PFAM
- AnimalTFDB
- TF Group
- Zinc-Coordinating Group
- Description
- DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which co-ordinates a single zinc atom. TR interacts with the thyroid response element, which is a DNA site with direct repeats of the consensus sequence 5'-AGGTCA-3' separated by one to five base pairs, upstream of target genes and modulates the rate of transcriptional initiation. Thyroid hormone receptor (TR) mediates the actions of thyroid hormones, which play critical roles in growth, development, and homeostasis in mammals. They regulate overall metabolic rate, cholesterol and triglyceride levels, and heart rate, and affect mood. TRs are expressed from two separate genes (alpha and beta) in human and each gene generates two isoforms of the receptor through differential promoter usage or splicing. TRalpha functions in the heart to regulate heart rate and rhythm and TRbeta is active in the liver and other tissues. The unliganded TRs function as transcription repressors, by binding to thyroid hormone response elements (TRE) predominantly as homodimers, or as heterodimers with retinoid X-receptors (RXR), and being associated with a complex of proteins containing corepressor proteins. Ligand binding promotes corepressor dissociation and binding of a coactivator to activate transcription. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, TR has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [4, 3, 5, 2, 7, 1, 6]
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 23 4.6e-24 1.5e-20 75.6 0.1 13 156 111 253 104 263 0.90 2 23 0.0093 30 6.1 0.1 102 156 248 301 246 313 0.87 3 23 0.0085 27 6.2 0.1 102 156 296 349 267 354 0.83 4 23 0.01 32 6.0 0.3 102 156 344 397 315 423 0.82 5 23 0.0057 18 6.8 0.2 102 156 436 489 406 500 0.82 6 23 0.011 34 5.9 0.1 102 156 484 537 472 544 0.88 7 23 0.0075 24 6.4 0.1 102 156 532 585 502 591 0.82 8 23 0.0088 28 6.1 0.1 102 156 580 633 552 638 0.84 9 23 0.011 33 5.9 0.4 102 156 628 681 598 706 0.82 10 23 0.49 1.6e+03 0.4 0.1 113 156 683 725 679 735 0.87 11 23 0.25 7.9e+02 1.4 0.1 113 156 727 769 718 778 0.87 12 23 0.0057 18 6.8 0.2 102 156 764 817 735 828 0.82 13 23 0.0083 26 6.2 0.1 102 156 812 865 800 876 0.87 14 23 0.011 34 5.8 0.1 102 156 860 913 858 923 0.88 15 23 0.0055 17 6.8 0.2 102 156 908 961 880 974 0.83 16 23 0.0088 28 6.1 0.1 102 156 956 1009 945 1020 0.88 17 23 0.007 22 6.5 0.1 102 156 1004 1057 986 1069 0.86 18 23 0.011 34 5.8 0.1 102 156 1052 1105 1050 1115 0.88 19 23 0.0055 17 6.8 0.2 102 156 1100 1153 1070 1165 0.81 20 23 0.0084 26 6.2 0.1 102 156 1148 1201 1136 1212 0.87 21 23 0.006 19 6.7 0.2 102 156 1196 1249 1168 1260 0.83 22 23 0.022 71 4.8 0.1 102 156 1244 1297 1232 1299 0.89 23 23 1e-10 3.2e-07 32.1 0.1 113 182 1299 1367 1295 1381 0.93
Sequence Information
- Coding Sequence
- ATGCCTTCCACCAGCAATAATCCTGATGTTAACAAAGCCAGAGACATACTACAGGATGTGGAAAGAATAGAACCGAATTCAATGGAGTCAATATTATGTGAAGCAATAAAGTTAGAGTTTGAAGCTTACACCTCGGTCAACTCTTGCAGCGGATCTTCTAGAGAGCTTAATGAaGTGGAACGTGCAAAATTGAATGAATTGATCGTCGCCAACAAGGCACTACACGCGCCTATAGACGATGACGTATCGCAACTGATCGGTGACTCAGCTAGTACCGCAGGACTAaagACAGGCGACGGCAAACATGATCCGAGACTGATAACAATAGTGAACCTTACCGCTGTCGCAATAAGGCGCTTTATCAAAATGGCGAAGAAAATTAACGCTTTCAAGAATATGTGCGAAGAGGATCAGGTAGCTCTTCTAAAAGGCGGCTGCATAGAGATGATGGTCCTTCGGAGTACAATGACTTATGACGGACAAAGGAATCAGTGGAAGCTCCCGCACAGCCAGAAGCAGTTCGGCAGCATCCACACGGACGTGCTGAAGCTGGCCAAAGGCGACGTGTACCGCTCGCACGAGGCGTTCGTGCGCTCGTTCGCGGCGCGCCTGCGCACGGACGAGCACGTGATCCTCATCATGTGCGCCATCCTGCTGTTCACGCCGCAGCGTGCGCGCGCCGTGCACCGCGACGTCATCAAGCTCGAGCAGGTACGTGAGTGGCAAGCACTAGACCGCACCACTTGCCGCAAGCAGCACGTGGACGAGCACGTGATCCTCATCATGTGCGCCATCCTGCTGTTCACGCCGCAGCGTGCGCGCGCCGTGCACCGCGACGTCATCAAGCTCGAGCAGGTACGTGAGTGGCAAGCACTAGACCGCACCACTTGCCGCAAGCAGCACGTGGACGAGCACGTGATCCTCATCATGTGCGCCATCCTGCTGTTCACGCCGCAGCGTGCGCGCGCCGTGCACCGCGACGTCATCAAGCTCGAGCAGGTACGTGAGTGGCAAGCACTAGACCGCACCACTTGCCGCAAGCAGCACGTGGACGAGCACGTGATCCTCATCATGTGCGCCATCCTGCTGTTCACGCCGCAGCGTGCGCGCGCCGTGCACCGCGACGTCATCAAGCTCGAGCAGGTACGTGAGTGGCAAGCACTAGACCGCACCACTTGCCGCAAGCAGCACGTGATCCTCATCATGTGCGCCATCCTGCTGTTCACGCCGCAGCGTGCGCGCGCCGTGCACCGCGACGTCATCAAGCTCGAGCAGGTACGTGAGTGGCAAGCACTAGACCGCACCACTTGCCGCAAGCAGCACGTGGACGAGCACGTGATCCTCATCATGTGCGCCATCCTGCTGTTCACGCCGCAGCGTGCGCGCGCCGTGCACCGCGACGTCATCAAGCTCGAGCAGGTACGTGAGTGGCAAGCACTAGACCGCACCACTTGCCGCAAGCAGCACGTGGACGAGCACGTGATCCTCATCATGTGCGCCATCCTGCTGTTCACGCCGCAGCGTGCGCGCGCCGTGCACCGCGACGTCATCAAGCTCGAGCAGGTACGTGAGTGGCAAGCACTAGACCGCACCACTTGCCGCAAGCAGCACGTGGACGAGCACGTGATCCTCATCATGTGCGCCATCCTGCTGTTCACGCCGCAGCGTGCGCGCGCCGTGCACCGCGACGTCATCAAGCTCGAGCAGGTACGTGAGTGGCAAGCACTAGACCGCACCACTTGCCGCAAGCAGCACGTGGACGAGCACGTGATCCTCATCATGTGCGCCATCCTGCTGTTCACGCCGCAGCGTGCGCGCGCCGTGCACCGCGACGTCATCAAGCTCGAGCAGGTACGTGAGTGGCAAGCACTAGACCGCACCACTTGCCGCAAGCAGCACGTGGACGAGCACGTGATCCTCATCATGTGCGCCATCCTGCTGTTCACGCCGCAGCGTGCGCGCGCCGTGCACCGCGACGTCATCAAGCTCGAGCAGGTACGTGAGTGGCAAGCACTAGACCGCACCACTTGCCGCAAGCAGCACGTGATCCTCATCATGTGCGCCATCCTGCTGTTCACGCCGCAGCGTGCGCGCGCCGTGCACCGCGACGTCATCAAGCTCGAGCAGGTACGTGAGTGGCAAGCACTAGACCGCACCACTTGCCGCAAGCAGCACGTGATCCTCATCATGTGCGCCATCCTGCTGTTCACGCCGCAGCGTGCGCGCGCCGTGCACCGCGACGTCATCAAGCTCGAGCAGGTACGTGAGTGGCAAGCACTAGACCGCACCACTTGCCGCAAGCAGCACGTGGACGAGCACGTGATCCTCATCATGTGCGCCATCCTGCTGTTCACGCCGCAGCGTGCGCGCGCCGTGCACCGCGACGTCATCAAGCTCGAGCAGGTACGTGAGTGGCAAGCACTAGACCGCACCACTTGCCGCAAGCAGCACGTGGACGAGCACGTGATCCTCATCATGTGCGCCATCCTGCTGTTCACGCCGCAGCGTGCGCGCGCCGTACATCGCGACGTCATCAAGCTCGAGCAGGTACGTGAGTGGCAAGCACTAGACCGCACCACTTGCCGCAAGCAGCACGTGGACGAGCACGTGATCCTCATCATGTGCGCCATCCTGCTGTTCACGCCGCAGCGTGCGCGCGCCGTACATCGCGACGTCATCAAGCTCGAGCAGGTACGTGAGTGGCAAGCACTAGACCGCACCACTTGCCGCAAGCAGCACGTGGACGAGCACGTGATCCTCATCATGTGCGCCATCCTGCTGTTCACGCCGCAGCGTGCGCGCGCCGTGCACCGCGACGTCATCAAGCTCGAGCAGGTACGTGAGTGGCAAGCACTAGACCGCACCACTTGCCGCAAGCAGCACGTGGACGAGCACGTGATCCTCATCATGTGCGCCATCCTGCTGTTCACGCCGCAGCGTGCGCGCGCCGTGCACCGCGACGTCATCAAGCTCGAGCAGGTACGTGAGTGGCAAGCACTAGACCGCACCACTTGCCGCAAGCAGCACGTGGACGAGCACGTGATCCTCATCATGTGCGCCATCCTGCTGTTCACGCCGCAGCGTGCGCGCGCCGTACATCGCGACGTCATCAAGCTCGAGCAGGTACGTGAGTGGCAAGCACTAGACCGCACCACTTGCCGCAAGCAGCACGTGGACGAGCACGTGATCCTCATCATGTGCGCCATCCTGCTGTTCACGCCGCAGCGTGCGCGCGCCGTACATCGCGACGTCATCAAGCTCGAGCAGGTACGTGAGTGGCAAGCACTAGACCGCACCACTTGCCGCAAGCAGCACGTGGACGAGCACGTGATCCTCATCATGTGCGCCATCCTGCTGTTCACGCCGCAGCGTGCGCGCGCCGTACATCGCGACGTCATCAAGCTCGAGCAGGTACGTGAGTGGCAAGCACTAGACCGCACCACTTGCCGCAAGCAGCACGTGGACGAGCACGTGATCCTCATCATGTGCGCCATCCTGCTGTTCACGCCGCAGCGTGCGCGCGCCGTGCACCGCGACGTCATCAAGCTCGAGCAGGTACGTGAGTGGCAAGCACTAGACCGCACCACTTGCCGCAAGCAGCACGTGGACGAGCACGTGATCCTCATCATGTGCGCCATCCTGCTGTTCACGCCGCAGCGTGCGCGCGCCGTGCACCGCGACGTCATCAAGCTCGAGCAGGTACGTGAGTGGCAAGCACTAGACCGCACCACTTGCCGCAAGCAGCACGTGGACGAGCACGTGATCCTCATCATGTGCGCCATCCTGCTGTTCACGCCGCAGCGTGCGCGCGCCGTGCACCGCGACGTCATCAAGCTCGAGCAGGTACGTGAGTGGCAAGCACTAGACCGCACCACTTGCCGCAAGCAGCACGTGATCCTCATCATGTGCGCCATCCTGCTGTTCACGCCGCAGCGTGCGCGCGCCGTGCACCGCGACGTCATCAAGCTCGAGCAGAACTCCTACTATTATCTCCTACGGAGGTACCTAGAAAGTATATACCCAGGTTGTGAAGCAAAGTCTACGTTCCTTAAACTAATACAGAAGATTTTGGAACTTAGGAAGCTCGCTGAAGAACTAACAGGGGTGTATTTGGACGTTAACCCAATAGAGCCATTGTTAATGGAGATATTTGACTTGAAGCATCACGCTGCATGA
- Protein Sequence
- MPSTSNNPDVNKARDILQDVERIEPNSMESILCEAIKLEFEAYTSVNSCSGSSRELNEVERAKLNELIVANKALHAPIDDDVSQLIGDSASTAGLKTGDGKHDPRLITIVNLTAVAIRRFIKMAKKINAFKNMCEEDQVALLKGGCIEMMVLRSTMTYDGQRNQWKLPHSQKQFGSIHTDVLKLAKGDVYRSHEAFVRSFAARLRTDEHVILIMCAILLFTPQRARAVHRDVIKLEQVREWQALDRTTCRKQHVDEHVILIMCAILLFTPQRARAVHRDVIKLEQVREWQALDRTTCRKQHVDEHVILIMCAILLFTPQRARAVHRDVIKLEQVREWQALDRTTCRKQHVDEHVILIMCAILLFTPQRARAVHRDVIKLEQVREWQALDRTTCRKQHVILIMCAILLFTPQRARAVHRDVIKLEQVREWQALDRTTCRKQHVDEHVILIMCAILLFTPQRARAVHRDVIKLEQVREWQALDRTTCRKQHVDEHVILIMCAILLFTPQRARAVHRDVIKLEQVREWQALDRTTCRKQHVDEHVILIMCAILLFTPQRARAVHRDVIKLEQVREWQALDRTTCRKQHVDEHVILIMCAILLFTPQRARAVHRDVIKLEQVREWQALDRTTCRKQHVDEHVILIMCAILLFTPQRARAVHRDVIKLEQVREWQALDRTTCRKQHVILIMCAILLFTPQRARAVHRDVIKLEQVREWQALDRTTCRKQHVILIMCAILLFTPQRARAVHRDVIKLEQVREWQALDRTTCRKQHVDEHVILIMCAILLFTPQRARAVHRDVIKLEQVREWQALDRTTCRKQHVDEHVILIMCAILLFTPQRARAVHRDVIKLEQVREWQALDRTTCRKQHVDEHVILIMCAILLFTPQRARAVHRDVIKLEQVREWQALDRTTCRKQHVDEHVILIMCAILLFTPQRARAVHRDVIKLEQVREWQALDRTTCRKQHVDEHVILIMCAILLFTPQRARAVHRDVIKLEQVREWQALDRTTCRKQHVDEHVILIMCAILLFTPQRARAVHRDVIKLEQVREWQALDRTTCRKQHVDEHVILIMCAILLFTPQRARAVHRDVIKLEQVREWQALDRTTCRKQHVDEHVILIMCAILLFTPQRARAVHRDVIKLEQVREWQALDRTTCRKQHVDEHVILIMCAILLFTPQRARAVHRDVIKLEQVREWQALDRTTCRKQHVDEHVILIMCAILLFTPQRARAVHRDVIKLEQVREWQALDRTTCRKQHVDEHVILIMCAILLFTPQRARAVHRDVIKLEQVREWQALDRTTCRKQHVILIMCAILLFTPQRARAVHRDVIKLEQNSYYYLLRRYLESIYPGCEAKSTFLKLIQKILELRKLAEELTGVYLDVNPIEPLLMEIFDLKHHAA
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -