Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00021 0.021 15.9 6.2 1 23 92 114 92 114 0.98

2 6 3.2e-05 0.0033 18.4 1.3 1 23 120 142 120 142 0.98

3 6 0.00016 0.017 16.2 5.4 1 23 148 170 148 170 0.98

4 6 4.6e-06 0.00047 21.1 1.6 2 23 177 198 176 198 0.96

5 6 2e-06 0.0002 22.2 3.2 1 23 204 226 204 226 0.98

6 6 6.2e-06 0.00063 20.7 1.2 1 23 232 254 232 254 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00021	0.021	15.9	6.2	1	23	92	114	92	114	0.98
2	6	3.2e-05	0.0033	18.4	1.3	1	23	120	142	120	142	0.98
3	6	0.00016	0.017	16.2	5.4	1	23	148	170	148	170	0.98
4	6	4.6e-06	0.00047	21.1	1.6	2	23	177	198	176	198	0.96
5	6	2e-06	0.0002	22.2	3.2	1	23	204	226	204	226	0.98
6	6	6.2e-06	0.00063	20.7	1.2	1	23	232	254	232	254	0.98

Coding Sequence: ATGGCAAATATTGTTCCAATAATAAGGAATACTGAAATAAAACCTTTAttcaaaaatatagaaaataatataaataaaacaaccaTTATGGAAGATATAGacagaaatgaaataaaaaacaaagaatCCTTTCATTTTGGGCCATTAAACACCAAAGGACTGACCCTAGATATGAAGTCTCATGTAATCTCAACTAATTTTAACCAGTTGGATATATTAACTGAAAACACAAACATACAAACTAATTCATGTTACAAACATGTTAAAGAAATGCACAAATGTCGAAATTGCAGCAagcaatataaaaataagaagtcaCTGACACTGCACATGAAGTTACATACATTACAAAACATATTCacatgtaaaatttgtacaaagGTGTTCACAATAAAACGTAAATATGAGATTCATATTCTTAGTCATTCTGGAGTGAAATTGTATTCATGTAAAACATGCGAGAGAAAGTTCACTGCAAAACACTCTCTGGAAACTCACATGCACATTCATAGCGGGTATAAACCAGTCCAGTGTGAAATATGTGGAATGAGATTCTCCAAGAAGAGCTCTCTTCACAGGCACTCCCTTATCCATAGTGGTGTAAAGCCATACAATTGTAAAACATGCAACAAGTCTTTCACGCAGAAAATACAACTTTCAAACCATGAGAAGACTCACAATGGTATCCGACCATACGTCTGTGCTAGTTGTGGAAAGAGTTTTTGTAGAAAAGATGTATTAAATGTGCATAGTAGGGTTCATTATAATGAGTTACggaaagtgaaataa
Protein Sequence: MANIVPIIRNTEIKPLFKNIENNINKTTIMEDIDRNEIKNKESFHFGPLNTKGLTLDMKSHVISTNFNQLDILTENTNIQTNSCYKHVKEMHKCRNCSKQYKNKKSLTLHMKLHTLQNIFTCKICTKVFTIKRKYEIHILSHSGVKLYSCKTCERKFTAKHSLETHMHIHSGYKPVQCEICGMRFSKKSSLHRHSLIHSGVKPYNCKTCNKSFTQKIQLSNHEKTHNGIRPYVCASCGKSFCRKDVLNVHSRVHYNELRKVK

Sequence clustering based on sequence similarity using MMseqs2