Basic Information

Gene Symbol
-
Assembly
GCA_018244795.1
Location
DWME01013143.1:4189-7680[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.00038 0.027 15.5 0.6 1 23 306 329 306 329 0.95
2 10 0.028 2 9.7 1.6 1 19 345 363 345 367 0.92
3 10 3.9e-05 0.0028 18.6 3.8 2 23 373 394 372 394 0.97
4 10 0.00073 0.052 14.6 0.3 1 23 398 421 398 421 0.94
5 10 0.00018 0.013 16.5 0.3 2 23 530 551 530 551 0.95
6 10 0.14 9.7 7.5 0.1 2 23 571 593 570 593 0.95
7 10 1.1e-06 8.1e-05 23.5 4.1 1 23 599 621 599 621 0.98
8 10 6.3e-05 0.0045 18.0 2.4 1 23 626 648 626 648 0.98
9 10 0.002 0.14 13.3 3.6 2 21 655 674 654 677 0.94
10 10 0.12 8.8 7.6 3.0 3 19 717 733 716 738 0.92

Sequence Information

Coding Sequence
ATGGAGACGGACGGGTACGTGTCGAGTGGCAGTAGCTTGTATCCTGTGCTCTTTTTACCCAAGAGTTGCACTACACTGGAAACCAATTGTGAAGCTTctgataatgtttttattgactTGAACATAACATCCTCTGATACAGAAGGGAGCGAAACAACTATTTACTCCGGgttttgtaatgttaaattgGTAGACAGTTATGATATGAACTTTAATATGAATGTGTCAGATCAGGGGCTGCATGGTGGAACCGCAACAGAGGGGAACAGTGATCAGGGTGCTGTGTTAGATGTAGGAAGCTCATATCCTCCTTACAGCCAATCTCAAGTATGGATAGACCCTGCAAGAAGtccatatgtatataacagatGTGACACAGCAGAATCACAGGAACGTTATTCAGTATACCAATCTCAAACCAGTCACATAACAGTGGAGCagcataatacatatatcacaaaaaatatctacaacTCCAAAGAATCTATTCATTATTCACCAGGAGAAGAATTTGAACATAAGAAATTTAGGAAAAACCAAAATGAGTTACATCAAAGCAATATAGGGGATCAGAATTTTTATGAAGATGACGAGTTTGAATGTGGTGTATTCCTTTCTAAACTCCCTGAAGAAATTTGGAATGAAAAGGAGACTCGAGCAAGAGAGGAAATGAAGTATGTAGGATTACACAGTGAGGACAATGCACTGAAACAATTGATGTCATCAGATATACAGTCAATGTCAAAACAACAGAAGACAATTTTGTTCCTCGGTCATGACTCTCATTTTGGTCAAACAATACAGAAGATAGCCATCAATGATCCATATTTGGAGTGTGTTGGTGCTGATCAAAGTGAGGTTGAAACTGAAGTTAAAACCAATAAAGCTAAATTTATAAAGCCGAATCAAAAGAAATATCAATGCGACAAATGTAAACAGATATTTAATCAAATCGCTGAGTTCAAACAACACATGATCGGGAACCATAAAAGTCCAAAAGCGACCGTCATGACGGGCGCCAGCGAAATGAATTTCATGTGCTTGGAATGCGGTAAAAGCCTTAGAAACCAGGAGAAGTTTGAGCTCCACTGCCTCGGCCACGGCGACCCGGAGCTAGAATGTAACAAGTGCCACAAAGTGTTTGCGTCAAAATTTACCCTTCGCACCCACAGAAAGATACATTCAAGAAAATATCCCTGTAAATACTGCGCGAAAACCTACTCCAGTGATGAGGAGTTGAAGACTCATGCAGCGAAAGtacattttatgttcttttGTGATTTATGTACGTTTGCAGCCGATAATTACAAAGTGCTAATGGAGCACAAGGTCTCGCATAGGGTATTGGGACAAGAGAGTATTGACGTAGAATGCAATGTTTCACTCGGAGAGGAATTGATCAATGAAAGTGATACTCCCACACCTATGGCTGACAATTCCGAACTTGAGACCGTAGAACAGGAAATCATAGGATTAAACCGTCAAGAAGAGATATCGCGAGCTGACTCCATTATAGCCAAAGTCGTCGCAAATGAGGTGTTCCTCCGGCACACCAAAAAGTCAAAACGCAgcaataagtataaaaatAGTTGCGACGTCTGTCAGAAAAAGTTCGACCGAGTCGGAGATCTTAAACGGCATCTCATAGAACATGTTATAAGAAGCACACTCAAAAAAAACCCAGTCAATAATCACGGAGCCCTGAACATTGTTTGCGAAGTCTGTCAAGCAGAATCCTTCACGAAAATAGATAAGTATAAAGCACATTTACGTGAACACGCCAAAGTTACTCTATATAAATGCACATTTTGTGACAAATCCTTCAGTGATTCCAGCAACTTCTCTAAACACAAGAAAATACACGGATCGACATTCTTTCAATGCGATTTATGTCAACGCAAGTTCAATtccaaaaaaatgttaacactGCACATGGAGTATCATAACAAAAACTCTCCTATTCACTGCTATTACTGTAACAAGGTATTTTACTTCGAATCAATGTTGAATAAACACATCCGATGCGCTCATACAAAACAAATGTGTTCTAGATTTCGATGTAGATTCTGCCACCAATATTTCAGATGTTTAAAAGAGAAATGGGACCATGAATGGATGGTtcataatgtaagaaaaatgaTAGTTGATTGCAGAATTTGTAGCGCGAAGTTCAGAAAGTATTCAGAGTTAAAACGTCATTGCAGTAATGTCCATAATATGGACATACCCTCAGCGAAAAGATTACTcaaaaatggaaaatttatgTAA
Protein Sequence
METDGYVSSGSSLYPVLFLPKSCTTLETNCEASDNVFIDLNITSSDTEGSETTIYSGFCNVKLVDSYDMNFNMNVSDQGLHGGTATEGNSDQGAVLDVGSSYPPYSQSQVWIDPARSPYVYNRCDTAESQERYSVYQSQTSHITVEQHNTYITKNIYNSKESIHYSPGEEFEHKKFRKNQNELHQSNIGDQNFYEDDEFECGVFLSKLPEEIWNEKETRAREEMKYVGLHSEDNALKQLMSSDIQSMSKQQKTILFLGHDSHFGQTIQKIAINDPYLECVGADQSEVETEVKTNKAKFIKPNQKKYQCDKCKQIFNQIAEFKQHMIGNHKSPKATVMTGASEMNFMCLECGKSLRNQEKFELHCLGHGDPELECNKCHKVFASKFTLRTHRKIHSRKYPCKYCAKTYSSDEELKTHAAKVHFMFFCDLCTFAADNYKVLMEHKVSHRVLGQESIDVECNVSLGEELINESDTPTPMADNSELETVEQEIIGLNRQEEISRADSIIAKVVANEVFLRHTKKSKRSNKYKNSCDVCQKKFDRVGDLKRHLIEHVIRSTLKKNPVNNHGALNIVCEVCQAESFTKIDKYKAHLREHAKVTLYKCTFCDKSFSDSSNFSKHKKIHGSTFFQCDLCQRKFNSKKMLTLHMEYHNKNSPIHCYYCNKVFYFESMLNKHIRCAHTKQMCSRFRCRFCHQYFRCLKEKWDHEWMVHNVRKMIVDCRICSAKFRKYSELKRHCSNVHNMDIPSAKRLLKNGKFM

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-