Basic Information

Gene Symbol
Znf526
Assembly
GCA_001298355.1
Location
NW:151212-165871[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 26 0.00048 0.026 14.6 3.8 1 23 279 301 279 301 0.98
2 26 3.7 2e+02 2.4 0.2 1 23 308 330 308 330 0.92
3 26 1.5 78 3.7 0.1 1 23 334 357 334 357 0.84
4 26 0.12 6.7 7.0 6.1 1 23 364 386 364 387 0.96
5 26 9.2e-07 4.9e-05 23.2 0.3 2 23 393 414 393 414 0.98
6 26 8.7e-06 0.00046 20.1 1.1 1 23 420 442 420 442 0.99
7 26 0.00026 0.014 15.5 1.4 1 21 448 468 448 473 0.93
8 26 0.027 1.5 9.1 2.5 1 23 481 504 481 504 0.91
9 26 0.016 0.87 9.8 0.2 1 23 510 533 510 533 0.95
10 26 2.1e-05 0.0011 18.9 0.8 1 23 542 564 542 564 0.98
11 26 5.1e-05 0.0027 17.7 0.9 1 23 570 593 570 593 0.96
12 26 3.7e-05 0.002 18.1 0.8 1 23 616 639 616 639 0.97
13 26 3.7e-05 0.002 18.1 0.8 1 23 662 685 662 685 0.97
14 26 3.7e-05 0.002 18.1 0.8 1 23 708 731 708 731 0.97
15 26 3.7e-05 0.002 18.1 0.8 1 23 754 777 754 777 0.97
16 26 3.7e-05 0.002 18.1 0.8 1 23 800 823 800 823 0.97
17 26 3.7e-05 0.002 18.1 0.8 1 23 846 869 846 869 0.97
18 26 3.7e-05 0.002 18.1 0.8 1 23 892 915 892 915 0.97
19 26 3.7e-05 0.002 18.1 0.8 1 23 938 961 938 961 0.97
20 26 3.7e-05 0.002 18.1 0.8 1 23 984 1007 984 1007 0.97
21 26 3.7e-05 0.002 18.1 0.8 1 23 1030 1053 1030 1053 0.97
22 26 3.7e-05 0.002 18.1 0.8 1 23 1076 1099 1076 1099 0.97
23 26 3.7e-05 0.002 18.1 0.8 1 23 1122 1145 1122 1145 0.97
24 26 3.7e-05 0.002 18.1 0.8 1 23 1168 1191 1168 1191 0.97
25 26 3.7e-05 0.002 18.1 0.8 1 23 1214 1237 1214 1237 0.97
26 26 3.7e-05 0.002 18.1 0.8 1 23 1260 1283 1260 1283 0.97

Sequence Information

Coding Sequence
ATGGAAGTTGATATTTCAAAGGATAATCAAGATTTGAAACCAGAAATCGAAATGCTAAATACTATTTGCCGCTGTTGTTTATCTAAAAACAGAAATGGGAATAATATAATGATGTATAGTGGACTATTTTTTGATTTGGCTGAAATAACTGTAACAGAATCAGATGGTTTACCGCAATGGCTGTGCTGGGAATGTATAGCGTTGCTGCAAAAATCTGTAAGGTTTAAACAAAAGCTGCAGAGATCACACATGTTATTGTACGAATATGTAACTAGATGTGCACCGTTCCCCATAGATGGTCAGGATCCGGAACTAACAAAATATGAGAGTCCACAGCTAAGTTCTACAACAACACTAGTCTTTGATAATGATAGCAGAAGTAAGAATGGATTTCATAAAGTACTAGAGcaTGAAAAACAGATATTAAATCCAATGAAGGAAACAATTAGTGTAATTGTTGAAAAAATTGAggataatattaaagaagaaACTAACTTTTCCGATTTTGAAGACAATTTGACATTAGAAGAATTtagaTCAAATGtaacgaaattaaaagatgacgtgaataaatttgaatgtgAAGAAATTACAGATACATCAATAGATAGGAAAAGAAAGAGGACAAAAGATAAAGTGGAAAAAgtgagaaagaaaaaaaaagtCACAGAAGTAACCGAAGCATTAGATGGCagtgatgaaaaaaaatctcgcAAAACTTCAATAAGGAAACCTCCGGAACTGGATCCTAAGAAAATaagagtaattattttaaatccggAAGAACAAATTAAGATGAAAGAGGAAGAAAGTAAAGCTTCAGACAAATTTCCCTTCCAATGTAAACTTTGCTTCAAAGGTTTCAACTTTGAGAGCAAATTACAGAATCACATGTTCAAGCATAGCCccTCTCGGGGCACATTCGAGTGCTCCCTGTGTCACATGTACTTGCCGAGCGCGTACAGTGCGAGTGTACACGCGCTCATACACACTCGCAGATATGAATGTCTCGAGTGTGGACGTAGAATGATTGATAGAGCTTCTATATTGGAACATTACAgCGCACAACATGAAGGTATTGTGAATCAATACACATGCAGTCAATGCGGTAAAGTTAGCAATAACAAGAAAACACATCGTAGTCATGTTCGCAACCATCATGAGTCTGACAGACCTCGTTGTGATCAGTGCGGCAAGAGCTTCGTCAACAAGGACTCCCTCGTTGAGCACATGCAGATACACGACGGTGTGAAGAACTACGTATGTCCCGAGTGTGGAGCTCGCTTCAGAACTAGGACACAGATGAGGGACCACAAGAGGAAACATTCCGATGAAAGGGACTATTACTGTGTCGAATGTGACACTAGattcaAATCGCCCAACAGTTTGAAACAGCATTTGCTGAAAAGTCGAAAACATGTCGACTCTCACAGTCTAAAATACTCGTGCATGTGCTGCGACAAACGTTTCCCAACTGAGCGCGCGTTACGTCACCACATCGGAGTGCAGCACGAGGGTGTGCGCGCGCATCGCTGTGTCCAGTGTCCCGCAGCGCTCGCCACGCGCAACTCACTCAACAAGCACGTGCGCGCCGTGCACGCCGGAGCACGACCACCCGCCAGGCATGTCTGCGACACGTGCGGCCGCGCGTTCAGGGGTAAGAGTGTGCTAATGAACCACGTGCGCACTCACACGGGCGAGAAGCCGTTCTCGTGCGCTGAGTGCGGCCGCCGCTTCACGCAGCGCACCGCCATGCGCACTCACACGCGTCTCGTACATCTCAAAGTGCGCCGCAACGCCAAGGTGAGTGTGTACACAGACAGACACGTGTCTACATGTACACTGTACTCGTGCGCTGAGTGCGGCCGCCGCTTCACGCAGCGCACCGCCATGCGCACTCACACGCGTCTCGTACATCTCAAAGTGCGCCGCAACGCCAAGGTGAGTGTGTACACAGACAGACACGTGTCTACATGTACACTGTACTCGTGCGCTGAGTGCGGCCGCCGCTTCACGCAGCGCACCGCCATGCGCACTCACACGCGTCTCGTACATCTCAAAGTGCGCCGCAACGCCAAGGTGAGTGTGTACACAGACAGACACGTGTCTACATGTACACTGTACTCGTGCGCTGAGTGCGGCCGCCGCTTCACGCAGCGCACCGCCATGCGCACTCACACGCGTCTCGTACATCTCAAAGTGCGCCGCAACGCCAAGGTGAGTGTGTACACAGACAGACACGTGTCTACATGTACACTGTACTCGTGCGCTGAGTGCGGCCGCCGCTTCACGCAGCGCACCGCCATGCGCACTCACACGCGTCTCGTACATCTCAAAGTGCGCCGCAACGCCAAGGTGAGTGTGTACACAGACAGACACGTGTCTACATGTACACTGTACTCGTGCGCTGAGTGCGGCCGCCGCTTCACGCAGCGCACCGCCATGCGCACTCACACGCGTCTCGTACATCTCAAAGTGCGCCGCAACGCCAAGGTGAGTGTGTACACAGACAGACACGTGTCTACATGTACACTGTACTCGTGCGCTGAGTGCGGCCGCCGCTTCACGCAGCGCACCGCCATGCGCACTCACACGCGTCTCGTACATCTCAAAGTGCGCCGCAACGCCAAGGTGAGTGTGTACACAGACAGACACGTGTCTACATGTACACTGTACTCGTGCGCTGAGTGCGGCCGCCGCTTCACGCAGCGCACCGCCATGCGCACTCACACGCGTCTCGTACATCTCAAAGTGCGCCGCAACGCCAAGGTGAGTGTGTACACAGACAGACACGTGTCTACATGTACACTGTACTCGTGCGCTGAGTGCGGCCGCCGCTTCACGCAGCGCACCGCCATGCGCACTCACACGCGTCTCGTACATCTCAAAGTGCGCCGCAACGCCAAGGTGAGTGTGTACACAGACAGACACGTGTCTACATGTACACTGTACTCGTGCGCTGAGTGCGGCCGCCGCTTCACGCAGCGCACCGCCATGCGCACTCACACGCGTCTCGTACATCTCAAAGTGCGCCGCAACGCCAAGGTGAGTGTGTACACAGACAGACACGTGTCTACATGTACACTGTACTCGTGCGCTGAGTGCGGCCGCCGCTTCACGCAGCGCACCGCCATGCGCACTCACACGCGTCTCGTACATCTCAAAGTGCGCCGCAACGCCAAGGTGAGTGTGTACACAGACAGACACGTGTCTACATGTACACTGTACTCGTGCGCTGAGTGCGGCCGCCGCTTCACGCAGCGCACCGCCATGCGCACTCACACGCGTCTCGTACATCTCAAAGTGCGCCGCAACGCCAAGGTGAGTGTGTACACAGACAGACACGTGTCTACATGTACACTGTACTCGTGCGCTGAGTGCGGCCGCCGCTTCACGCAGCGCACCGCCATGCGCACTCACACGCGTCTCGTACATCTCAAAGTGCGCCGCAACGCCAAGGTGAGTGTGTACACAGACAGACACGTGTCTACATGTACACTGTACTCGTGCGCTGAGTGCGGCCGCCGCTTCACGCAGCGCACCGCCATGCGCACTCACACGCGTCTCGTACATCTCAAAGTGCGCCGCAACGCCAAGGTGAGTGTGTACACAGACAGACACGTGTCTACATGTACACTGTACTCGTGCGCTGAGTGCGGCCGCCGCTTCACGCAGCGCACCGCCATGCGCACTCACACGCGTCTCGTACATCTCAAAGTGCGCCGCAACGCCAAGGTGAGTGTGTACACAGACAGACACGTGTCTACATGTACACTGTACTCGTGCGCTGAGTGCGGCCGCCGCTTCACGCAGCGCACCGCCATGCGCACTCACACGCGTCTCGTACATCTCAGCACAATAACTGGTCTTCTTACCGTGGTAACAGTAAAACTCAACATCAAAGAATGCAGCATAGATCAAATAACTACAAAGAGAGAGGAAGAGCTAACAAAGTACGAATGGATTCAGTGA
Protein Sequence
MEVDISKDNQDLKPEIEMLNTICRCCLSKNRNGNNIMMYSGLFFDLAEITVTESDGLPQWLCWECIALLQKSVRFKQKLQRSHMLLYEYVTRCAPFPIDGQDPELTKYESPQLSSTTTLVFDNDSRSKNGFHKVLEHEKQILNPMKETISVIVEKIEDNIKEETNFSDFEDNLTLEEFRSNVTKLKDDVNKFECEEITDTSIDRKRKRTKDKVEKVRKKKKVTEVTEALDGSDEKKSRKTSIRKPPELDPKKIRVIILNPEEQIKMKEEESKASDKFPFQCKLCFKGFNFESKLQNHMFKHSPSRGTFECSLCHMYLPSAYSASVHALIHTRRYECLECGRRMIDRASILEHYSAQHEGIVNQYTCSQCGKVSNNKKTHRSHVRNHHESDRPRCDQCGKSFVNKDSLVEHMQIHDGVKNYVCPECGARFRTRTQMRDHKRKHSDERDYYCVECDTRFKSPNSLKQHLLKSRKHVDSHSLKYSCMCCDKRFPTERALRHHIGVQHEGVRAHRCVQCPAALATRNSLNKHVRAVHAGARPPARHVCDTCGRAFRGKSVLMNHVRTHTGEKPFSCAECGRRFTQRTAMRTHTRLVHLKVRRNAKVSVYTDRHVSTCTLYSCAECGRRFTQRTAMRTHTRLVHLKVRRNAKVSVYTDRHVSTCTLYSCAECGRRFTQRTAMRTHTRLVHLKVRRNAKVSVYTDRHVSTCTLYSCAECGRRFTQRTAMRTHTRLVHLKVRRNAKVSVYTDRHVSTCTLYSCAECGRRFTQRTAMRTHTRLVHLKVRRNAKVSVYTDRHVSTCTLYSCAECGRRFTQRTAMRTHTRLVHLKVRRNAKVSVYTDRHVSTCTLYSCAECGRRFTQRTAMRTHTRLVHLKVRRNAKVSVYTDRHVSTCTLYSCAECGRRFTQRTAMRTHTRLVHLKVRRNAKVSVYTDRHVSTCTLYSCAECGRRFTQRTAMRTHTRLVHLKVRRNAKVSVYTDRHVSTCTLYSCAECGRRFTQRTAMRTHTRLVHLKVRRNAKVSVYTDRHVSTCTLYSCAECGRRFTQRTAMRTHTRLVHLKVRRNAKVSVYTDRHVSTCTLYSCAECGRRFTQRTAMRTHTRLVHLKVRRNAKVSVYTDRHVSTCTLYSCAECGRRFTQRTAMRTHTRLVHLKVRRNAKVSVYTDRHVSTCTLYSCAECGRRFTQRTAMRTHTRLVHLKVRRNAKVSVYTDRHVSTCTLYSCAECGRRFTQRTAMRTHTRLVHLKVRRNAKVSVYTDRHVSTCTLYSCAECGRRFTQRTAMRTHTRLVHLSTITGLLTVVTVKLNIKECSIDQITTKREEELTKYEWIQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-