Phel056398.1
Basic Information
- Insect
- Papilio helenus
- Gene Symbol
- RUNX3
- Assembly
- GCA_026546675.1
- Location
- JAOCNA010000007.1:2485887-2497474[-]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 2.2e-70 2e-66 222.7 0.1 11 129 2 120 1 120 0.99
Sequence Information
- Coding Sequence
- ATGTCTCTGGTTCGTACTGGGAGCCCTGACTACATGTGTTCAATgctgccacagcattggcgctccaacaagacgctacccggcggcttcaaggtggtagctctaggtgaagtggtagacgggacgttggtcaccgtccgtgccggcaacgacgagaacatcaccgctgaacttagaaacaacaccgccgtcatgaagaatagagtagccaaatttaacgacttgaggttcgtcgggagaagtgggagagGTAAAAGTTTTTCTCTGACAATCACGGTGTCAACGTCCCCTCCTCAAGTGGCAACGTATCAAAAGGCAATCAAGGTGACAGTGGACGGACCCAGAGAGCCGCGTTCCAAAACAAGTACAAATGTATCAACGCATAGAACGCTCGACTTCCACCGGCAGTTCATCTCGTGCCCGCCGCTGCCTCTTCGCGAGGAGTACAAAAACCCAACTTCGAGAAGTCTAAGGACGCTGTCACACGAGGAAAGGGAATACAAAACCAACGCTACTATACCTAGTGGAGGTTAG
- Protein Sequence
- MSLVRTGSPDYMCSMLPQHWRSNKTLPGGFKVVALGEVVDGTLVTVRAGNDENITAELRNNTAVMKNRVAKFNDLRFVGRSGRGKSFSLTITVSTSPPQVATYQKAIKVTVDGPREPRSKTSTNVSTHRTLDFHRQFISCPPLPLREEYKNPTSRSLRTLSHEEREYKTNATIPSGG
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00042406;
- 90% Identity
- iTF_01148609; iTF_01337550; iTF_01138740; iTF_01115491; iTF_01147203; iTF_00840102; iTF_01141422; iTF_01141421; iTF_01175984;
- 80% Identity
- iTF_01148609;