Pgig000125.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Papilio gigon
Gene Symbol
NFIX
Assembly
GCA_027563995.1
Location
JAODUI010000016.1:438542-450056[+]

Transcription Factor Domain

TF Family
CTF_NFI
Domain
CTF/NFI and MH1 domain
PFAM
PF00859
TF Group
Unclassified Structure
Description
Nuclear factor I (NF-I) or CCAAT box-binding transcription factor (CTF) [2, 1, 5] (also known as TGGCA-binding proteins) are a family of vertebrate nuclear proteins which recognise and bind, as dimers, the palindromic DNA sequence 5'-TGGCANNNTGCCA-3'. This family was first described for its role in stimulating the initiation of adenovirus DNA replication [6]. In vertebrates there are four members NFIA, NFIB, NFIC, and NFIX and an orthologue from Caenorhabditis elegans has been described, called Nuclear factor I family protein (NFI-I) [4]. The CTF/NF-I proteins are individually capable of activating transcription and DNA replication, thus they function by regulating cell proliferation and differentiation. They are involved in normal development and have been associated with developmental abnormalities and cancer in humans [5]. In a given species, there are a large number of different CTF/NF-I proteins, generated both by alternative splicing and by the occurrence of four different genes. CTF/NF-1 proteins contain 400 to 600 amino acids. The N-terminal 200 amino-acid sequence, almost perfectly conserved in all species and genes sequenced, mediates site-specific DNA recognition, protein dimerisation and Adenovirus DNA replication. The C-terminal 100 amino acids contain the transcriptional activation domain. This activation domain is the target of gene expression regulatory pathways elicited by growth factors and it interacts with basal transcription factors and with histone H3 [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 0.0047 47 3.8 0.0 4 30 297 323 294 337 0.87
2 2 1.1e-08 0.00011 22.3 10.5 166 272 400 517 346 527 0.68

Sequence Information

Coding Sequence
ATGAGCGATTGTCGGTACTGCCAGGAATTGCCACGTGCGCGGAGGTCCTGCCAAGTGGGCACCCTGGCAAGTCTGGCGAGCCCGGCCAAACCAGGTGGTTCCCTCGCAACTTTGGCAGGATTCGCCCGCGTCTGCGAGAGCCGCCAACTACAATGTTATGACTGGTTCTTTGTTTACACTCGGGAGGAAATGTTAGCGCCTCGGCTAATCATTTACGACGAGTTCCATCCGTTCATAGAGGCACTCATGCCTTTTGTAAAGTCCTTTTCGTACACGTGGTTCAATTTACAAGCCGCAAAAAGGAAATATTACAAAAAACACGAGAAGCGGATGAGTCTTGAGGAGGAGCGGCACACCAAATATGAGTTACAGAACGAAAAAGCAGAAGTGAAACAAAAATGGGCGTCACGTCTACTGGGCAAGTTGAGGAAAGACATAACACAGGACTGCCGGGAGGATTTCGTGCTCAGCATAACAGGGAAGCGACCGGCGGTCTGCGTGCTGTCCAACCCCGATCAGAAGGGAAAGATGAGGAGGATAGACTGTCTAAGACAAGCGGATAAGGTGTGGCGATTAGATCTGGTGATGGTGATATTATTCAAAGCGATACCGCTAGAGAGCACGGACGGGGAGCGGCTGGAGAAGCACCCGGAGTGCACGCAGCCCGGCCTCTGCGTCAACCCCTACCACATCAACGTGTCCGTGCGCGAGCTGGACCTCTACCTCGCCAACTTCATCAACAGCTATGGTAATGGGAGCGACGGCCTGCCAGATATCCTAAGCGGTTCTCTGTCGCCCCACCCTCCTAGGGACAAAGAGAACGAACACGACGCTAAAAGTAAAGGCTATACTCACAATCCCTACAACGGTGTCATTTGCAACGATATTATTCTAGCAACCGGTGTCTTCTCATCGAAGGAACTATGGAAGTTGAGTAAAGCTTCGATCCTACAAGAGACGGGGTCCGAGTCGCCCGGTGGGTCGGGCATCAAGCTGGAGTCGGGCTACTACTGCGGATATGGCAGCCCGGCGCCGCCCGCCTTCGAGCCTCCCCCAGAGCGCGCCACTCCGTCCACCATGCTGGTCGGACAGTGCTTCAGTATTCCGCACAGCTCTGCGGCGCTGAGTACGCAGTCGCCGCTGGTGCCCTCTAACGCCATCTTCTACCAACACGCCCCGCCGCCCACCGACACACATCCCACTGCTTCAGAGCTGTCAAGTCAGCATTCCAGTGGAAAGTACGAGAGCGGACAGGACTCCCTCGGGGACTTCGTGACCTTCGTGTGTCAGGAGCCGCCCGCTGACGTGCAGCAGATACAGGTCCACGGCCTCTCGCGGAGTCCAAAGCCGGCGTACTTTACCAACTCAATGCTGCCGCCTCCTCCTCTGCCGCCGATGGCTAGGCCAGTAGCCATCATCAGATCAACGGCGAGTGAGGCTGGCGGCGTGGGCGTAGGCGTCGGCGTGGGCTCGGGCGTGGGCGTCGGCGGCGGGGGCAGCTCGCCTGCGTCTCCCGAGGGTCGGTCGCCGGGCGCCTCGCCGGGCCGCCGCTCACCACACTACCGCGACTGCCATCCCACGCTCACGCACTTTAACCACTTCCATGCGCAGCCGCAACAGGTGTTCAGCTACGGTGGGCTGGGCGGTGGCGCGGTGCTGGCGGGCGGCGGCGGCGGCTCCCCGCCAGGCGGGCTCGGCCTGTACGCGCCGCGCCCGCCGCCAAGAGCGCCCCCTAGGTGGAATGCTCCGTTCCCGACGTTAGAAGAGGAGTTCAACATTATGACTGCGCCCGGCGGGCCCGACCACGTCGTGCTATTGGATGATGAGCGTTTCTTCCAATCGAACGTGATAAGTGCGGAGGCGAGCGCGATGGACACGAGCTCGGGCGTGTGCCCGGCGGCGGAGGGCGAGGAGCTGGCGCCCGACAAGCCGCTGCGCTCGCCGTGA
Protein Sequence
MSDCRYCQELPRARRSCQVGTLASLASPAKPGGSLATLAGFARVCESRQLQCYDWFFVYTREEMLAPRLIIYDEFHPFIEALMPFVKSFSYTWFNLQAAKRKYYKKHEKRMSLEEERHTKYELQNEKAEVKQKWASRLLGKLRKDITQDCREDFVLSITGKRPAVCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKAIPLESTDGERLEKHPECTQPGLCVNPYHINVSVRELDLYLANFINSYGNGSDGLPDILSGSLSPHPPRDKENEHDAKSKGYTHNPYNGVICNDIILATGVFSSKELWKLSKASILQETGSESPGGSGIKLESGYYCGYGSPAPPAFEPPPERATPSTMLVGQCFSIPHSSAALSTQSPLVPSNAIFYQHAPPPTDTHPTASELSSQHSSGKYESGQDSLGDFVTFVCQEPPADVQQIQVHGLSRSPKPAYFTNSMLPPPPLPPMARPVAIIRSTASEAGGVGVGVGVGSGVGVGGGGSSPASPEGRSPGASPGRRSPHYRDCHPTLTHFNHFHAQPQQVFSYGGLGGGAVLAGGGGGSPPGGLGLYAPRPPPRAPPRWNAPFPTLEEEFNIMTAPGGPDHVVLLDDERFFQSNVISAEASAMDTSSGVCPAAEGEELAPDKPLRSP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01154004;
90% Identity
iTF_00840318;
80% Identity
iTF_01142415;