Basic Information

Gene Symbol
topi
Assembly
GCA_029641285.1
Location
CM056364.1:819485-824336[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.011 0.99 10.4 1.1 1 23 216 239 216 239 0.97
2 9 0.0007 0.062 14.2 2.3 2 23 247 268 246 268 0.97
3 9 0.12 10 7.2 0.1 2 23 304 326 303 326 0.95
4 9 0.02 1.8 9.7 2.0 2 23 329 351 328 351 0.94
5 9 1.3e-06 0.00012 22.8 0.5 1 23 357 379 357 379 0.96
6 9 0.00028 0.025 15.5 2.2 1 21 418 438 418 441 0.90
7 9 0.0038 0.34 11.9 1.8 1 23 447 470 447 470 0.96
8 9 2.9e-06 0.00026 21.7 2.4 1 23 478 500 478 500 0.96
9 9 0.00071 0.063 14.2 0.2 1 23 506 529 506 529 0.96

Sequence Information

Coding Sequence
ATGGAAGAAGAGGAATCAACGGATATGTGCCAAACTTGTCTCGTTCGTGGTCGTTTTCTGTATCCATTGCGTAAATTGACATCGACATTGAATGATGTGGGAATTCCTATACGGaaaGATGTGACCACTGGTGTATGTTGGGAGTGCAAGACCTTCATAATGaagattaagaaatttaaattacaagtgATCAGGGCACAGGACGCTCTGATGGAAATAGCATCGGTACCTAACCAAGATTTTCAATCTTTGAGCAGATTATCCTACTACACTAAATATCATTATGACttagaaatattatatacagatCCACTAAATAACTTTGAACTTGAAAACAATGAAGTTAAAAAGGAAGAAAACCTTTCTGATATAGAAATAGATCAGATACCTGACAATATTGataatacagaaaaaataatatataataaagataaaagctATGTACAAGATGCCACAAACTTTAAGGGCAATACACACAGTTGTAATGCAAAATTGATACACCGTGCTAAGAAAAAGAATATTCTAGATTCAAATACCTCAGAGAATTATGTTGAAGATAAGTATACAACTGTGGTGTTCACAGAAGAAGAAATGTTGaagaaaagagaagagaaaagaAACCAGCCCAACTTTAAGAAGATTCCGTATAAATGCGAATCTTGTGTACTAGGGTTTACACGCAGAGATAAGTACGATCAGCATATCGAGAAGAGACATGATATGaaacTAGGCACCAGCGTCTGCAATGTTTGTCAATCTCGGTTCAGCACTACCATGTCTTTGAAGAGGCATCGTATGAAGCATTATGTGGTCTACCGTTGTCGTCTCTGTGACTATGAGACGTTGGAATGTTGGTCGGTGGTCAGCCATTGCCGTCTGAAGCACAACAGAGATACAGATGGAAGAATACATTGTCCACAATGCTCCGTCATTGTACAgAACCCAAAGGCATTGTCTGAACACATAAATAGTGAACACTTGCTCCAATGTGCTCAATGTGGAGATAAATTTAAAGGGAAACATACGCTACGGAcacataaaatTCGTATCCATGGAGCAAAGCGTAACTTCATATGTGATATGTGCGGCAAGTCGTTCAACACCAAGTCTCGCCTCGAGTCGCATATAGTATCGCATAACGCTGAGCTCGCAACCAAGTTGGCGTACTGCGCGCCATGCAACGTCCAGTACAAGAATATATACGTGTATAGAAACCATCTCAAGAACAGTGCAAATCACTCGGAGAGAGCGTACGAGTGTAAGGAATGTAAGAAGAAATTCGCTTCCAAAGTGTACTGGCGGAAACATTGGGACTTTTACCACCTTCACAAGTCGCAGCATAAATGTGAGATATGCAATAAGCTGTTCATATCTGACTGGCGATTGAAGAACCACAGACAGATTCAACATGGACTTACAAGATCTAGGAATCACGCGTGCAATATTTGTGGAAAGAAATTCTTTACTCAATCAACACTACGTGGTCACCAGCTGACCCACTCCGAGGAGCGTAGCTACATGTGCGAGGACTGCGGGGACACGTTCAAGCAGCGCCCGGCGCTCTACACGCACTCGCGTCTCGTGCACAAGTCTAGCCGAGTGACCACAGTGACCGTTTCGACCACAAACTGA
Protein Sequence
MEEEESTDMCQTCLVRGRFLYPLRKLTSTLNDVGIPIRKDVTTGVCWECKTFIMKIKKFKLQVIRAQDALMEIASVPNQDFQSLSRLSYYTKYHYDLEILYTDPLNNFELENNEVKKEENLSDIEIDQIPDNIDNTEKIIYNKDKSYVQDATNFKGNTHSCNAKLIHRAKKKNILDSNTSENYVEDKYTTVVFTEEEMLKKREEKRNQPNFKKIPYKCESCVLGFTRRDKYDQHIEKRHDMKLGTSVCNVCQSRFSTTMSLKRHRMKHYVVYRCRLCDYETLECWSVVSHCRLKHNRDTDGRIHCPQCSVIVQNPKALSEHINSEHLLQCAQCGDKFKGKHTLRTHKIRIHGAKRNFICDMCGKSFNTKSRLESHIVSHNAELATKLAYCAPCNVQYKNIYVYRNHLKNSANHSERAYECKECKKKFASKVYWRKHWDFYHLHKSQHKCEICNKLFISDWRLKNHRQIQHGLTRSRNHACNICGKKFFTQSTLRGHQLTHSEERSYMCEDCGDTFKQRPALYTHSRLVHKSSRVTTVTVSTTN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01143349;
90% Identity
iTF_01143349;
80% Identity
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