Basic Information

Gene Symbol
Zfa
Assembly
GCA_029286655.1
Location
JAGSMY010000026.1:248714-254262[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 20 7.5e-05 0.0073 17.2 1.3 1 21 165 185 165 186 0.95
2 20 0.4 39 5.5 0.3 1 23 219 242 219 242 0.95
3 20 0.27 26 6.1 0.5 7 23 253 269 247 269 0.90
4 20 0.031 3 9.0 2.2 2 21 273 292 272 293 0.92
5 20 0.0045 0.44 11.7 1.0 2 23 331 353 330 353 0.95
6 20 2.8 2.7e+02 2.9 0.4 3 23 361 380 359 380 0.88
7 20 0.0085 0.83 10.8 0.7 1 23 385 407 385 407 0.98
8 20 0.0028 0.27 12.3 0.8 1 23 413 436 413 436 0.97
9 20 0.00021 0.02 15.8 2.0 1 23 445 467 445 467 0.97
10 20 0.26 25 6.1 6.5 1 19 475 493 475 496 0.95
11 20 3.1e-05 0.003 18.5 0.4 2 22 602 622 601 622 0.95
12 20 0.55 53 5.1 2.3 3 23 628 648 627 648 0.96
13 20 0.35 34 5.7 4.9 1 23 653 676 653 676 0.97
14 20 0.00014 0.014 16.4 0.3 1 23 681 703 681 703 0.94
15 20 1.2 1.2e+02 4.0 2.1 1 20 706 725 706 726 0.94
16 20 0.00096 0.093 13.8 1.5 1 23 739 762 739 762 0.97
17 20 0.31 30 5.9 1.4 2 23 769 790 768 790 0.80
18 20 1.2 1.2e+02 4.0 1.5 5 23 800 818 797 818 0.95
19 20 0.023 2.2 9.4 1.4 1 23 824 847 824 847 0.96
20 20 0.0057 0.56 11.3 3.3 1 22 855 876 855 878 0.89

Sequence Information

Coding Sequence
ATGAGTCGCCAAGTGGACATAAAAGCATTAGTTTCACATGTAGTTCGTGGAGAtggtataaataaatgcaGAATATGTATGGGGGACACATCGGAAGGCCAGGTTTTTCTCGGCGATACAGTATTGATGGACGGAGATCAACCTGTAACATTATCAGAACTGCTGGAAACTATAACAGGAGTTCAGATGGCGATCAGTGAAGAATTACCCGTCAACCTGTGCTCGTTTTGCTCCATGTCCGCAATAAGCGCTGCTGACTTCCGCACGGCTTGCAGACGAGCTGCCCATAAGTGGAACACTATTGTACAACTACTGACTAATCTACCACAACTTGGAAACGATGAAGCACTCTTTGCTGTAGTAGAAGACGACCAAATGGTCCTTCTAACGGATAACGAAAATATTTCGTCGGCCAAAATAGCAGCGAATAGATTAAATAGACTAACAAGACCTGTACAGAAACCAGAAATTGTCAAAACGCAAAAAGATCGTCACCAATGTCCTGATTGTGGTAAGCGGTTCGGCTACATCCATCAGCTGTATCGACACTTGAAGGAATCGACAGATTTGAAACGAGCATGTTACATTTGCGCGAAAATAATGAGCAGAGATGATTTAGTGGAACACTTAAAAGACCAGCATAATCGAAAACCTTACGACTGTAAAAAGTGCCCTGCTCTACTGCCTTCGTATAAGCAGTATGTTCAGCATTTACGCCAGGCGCATTCTCAAGGTTCCTGTACATGTGGTGATTATGGCCGAAGTTTCAAAACTTCCAACAGTTTTAGAGCTCATTTTTCAGTGCATACGATAAAGTCTTGTCCCAGCTGTGACAAAATATTTCGCAATCAAACTTGCTATTTGTATCACGTGAAAAAGTGTTGTAATTTAGAAGATAGAACACAAAACAACAAGACAATTGAAGTTAAGAATAAATGGAGTGATAAAAGAGTAAAAGTTGGTTTACGTGGAAGGATCGAGAAAGAATGTGTATGTGATTATTGTAATAAGAAATTCGCCGGAAAGAAATTTATATCGGCTCATATACAGATTGTGCATTTGAAAAATACGCATAGCCCATGCGTATACTGTGGGAAATTGCTAGCCGCGGCTCACATGTCTGAGCATATGAAGAAACATCAAGATTTGTCATTCAAATGTGACCTTTGTGGTGTTAAATTAAGAACTAAATTAGGTTACAGCCAGCATTTGCGATTGCACAGCGGTGAAAAGCCTTATCCGTGTCAGTACTGCAAGGAATCATTTTCAGCGTCCTCCAGACGTTCAGAACATATACGGAAAGTACATAAGAGTAGTGAAATAGTGTTAAAACATGAATGTAGTAAATGTTCAGCAAAGTTTCGACTACCCTACATGCTGAAGAAACATATGTTAGTGCACAATAGAGAAAGACAACAGCTTTTTGAATGTTACGAATGCCATGAGAAGTTTAATACCTGTACAACACTGTTAAAACATTGTAGGGTGGAGGAGGCGAAGAGTTTGCCGCGCGGAGTTTGTGCATCATGCACACAGATGGCGCTCACAGCAGCTCACTTTCGTAATGTCTGCCACGAATCCGCAAACCAATGGACACGAGCCACTTCCATCCTCAACTCTATATCAACTTCTCTACCACAAGATGAATCcttcttctttatttataacaaagatATCATAATCAAAGACAATAGTAATACATCGTGTACGTTAAAGACTGTTGatcgattaaataaattactccaAGAAACAACGGCCAAGATCACACAGCGCCAGAAAACGTTTAGGAAAGGCTCGCCCTGGAAATGCCAATACTGTGGAAAGAAATTTCGATTATTATACTCcctaaatgtacatttgagaATGACTTCAAACAGAGCTTGCACACATTGTGGTCTGATCATTAAGAAACAGAAGTTGCAACAACATTTAAGAAGATCACATAATGTACATTTGTTTCAATGTACCACATGTCACAAGTTATATAAAGAAGAATGTGAATTGGATAAACATAATCAAACAGCACACAGCGTTTTGTCATACTCCTGTCCAGTTTGCAAACAAAGTTTTGTAAACGAGAGAGCGCTACGAGCACACAAATACGCACACACTTTATTTAACTGCCTCTCCTGTAATACCAGCTTTGAAAACCTAAGATGTTACAGGTACCACATAGGTCATTGTCAAGGCTCGAAAGCACCACCAAATTCTTTATACGAATGCGATTACTGcggatataaatatttaaaaaaggattcTCTAAGAAGTcacattcaaaataaacatttgaaagTATTACAAATAGTGTGCCAGAAATGTGGCAAACGGAGTACAAGTCTCGCTCATCACAAGGCACATGAAGTCATCCACATGGAAGAAAGAAAAGTTTACAAATGTCACTGCGGTGCGAAGCTGACTACTCAGCTCGGTTACAACCTGCACCAAAGAATACATTCTGGTGAAAAACCTTATGAGTGTAAGAAATGTGGCGAAAGGTTTCTGTCTGCTTCAAGACGTTTGGATCACATGAAGAGGCGGCATATGAATATGGAAGACATGCCTCATAAATGTAGGGAATGCTCGGCTAAATTTATAAGGCCCTCATTGCTTAGGAAGCACTGTCAAGTCGTACATGGTATCTCCAGCTGA
Protein Sequence
MSRQVDIKALVSHVVRGDGINKCRICMGDTSEGQVFLGDTVLMDGDQPVTLSELLETITGVQMAISEELPVNLCSFCSMSAISAADFRTACRRAAHKWNTIVQLLTNLPQLGNDEALFAVVEDDQMVLLTDNENISSAKIAANRLNRLTRPVQKPEIVKTQKDRHQCPDCGKRFGYIHQLYRHLKESTDLKRACYICAKIMSRDDLVEHLKDQHNRKPYDCKKCPALLPSYKQYVQHLRQAHSQGSCTCGDYGRSFKTSNSFRAHFSVHTIKSCPSCDKIFRNQTCYLYHVKKCCNLEDRTQNNKTIEVKNKWSDKRVKVGLRGRIEKECVCDYCNKKFAGKKFISAHIQIVHLKNTHSPCVYCGKLLAAAHMSEHMKKHQDLSFKCDLCGVKLRTKLGYSQHLRLHSGEKPYPCQYCKESFSASSRRSEHIRKVHKSSEIVLKHECSKCSAKFRLPYMLKKHMLVHNRERQQLFECYECHEKFNTCTTLLKHCRVEEAKSLPRGVCASCTQMALTAAHFRNVCHESANQWTRATSILNSISTSLPQDESFFFIYNKDIIIKDNSNTSCTLKTVDRLNKLLQETTAKITQRQKTFRKGSPWKCQYCGKKFRLLYSLNVHLRMTSNRACTHCGLIIKKQKLQQHLRRSHNVHLFQCTTCHKLYKEECELDKHNQTAHSVLSYSCPVCKQSFVNERALRAHKYAHTLFNCLSCNTSFENLRCYRYHIGHCQGSKAPPNSLYECDYCGYKYLKKDSLRSHIQNKHLKVLQIVCQKCGKRSTSLAHHKAHEVIHMEERKVYKCHCGAKLTTQLGYNLHQRIHSGEKPYECKKCGERFLSASRRLDHMKRRHMNMEDMPHKCRECSAKFIRPSLLRKHCQVVHGISS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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