Basic Information

Gene Symbol
topi_1
Assembly
GCA_013186455.1
Location
QDHC01003372.1:1247990-1250097[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 8 0.0048 0.38 11.4 0.0 2 23 38 59 37 59 0.96
2 8 0.032 2.5 8.8 2.9 1 23 165 188 165 188 0.92
3 8 2.6e-06 0.00021 21.6 1.0 1 23 201 224 201 224 0.97
4 8 6.4e-06 0.00051 20.4 3.3 2 23 262 283 261 283 0.97
5 8 0.00057 0.045 14.3 5.4 1 23 289 311 289 311 0.97
6 8 2.1e-05 0.0017 18.8 4.3 1 23 317 339 317 339 0.98
7 8 8.3e-06 0.00066 20.1 3.4 1 23 345 367 345 367 0.98
8 8 0.08 6.4 7.5 5.0 1 20 373 392 373 394 0.93

Sequence Information

Coding Sequence
ATGAGTGCTGACGCAGCGTCCTTACCGTGTCCAATATGTTTACATACTGGTGTTTTCAACTCTGCTCAAGCGTTAAAAGACAGATTGATCTACGTCTCCACCAACAATATAGTGTGTCCAATATGTCAGGAATCTTTGTCAGGACTGGATAAATTAACCATACATCTCTTCAGTCACGTTTCGTTATTATCGCCACAAGGATTGTTGGAAAATGAAAAGACGGAGCCAAAATCTGAAGCTAAACATGCGAGCCACAAATCTCATACGACTACGACGATGAAGAAAACAAGAACGACGGCACcttctaaaaataaagtaccaGTGACTTCGGCGCCAGTTAAGTTCGTTAAAATATATCCAAAGTTACCAGTGATTGCTTTGAATACTGTTCCCATTATAGATTTACAGAGTACCGTAGATGGATgtgttcaaaataataattcgatGTACATACAAACCATGAAAACTGAAACAACTACCGTGAAAACCGACCataaatgtaatgtttgtGGTTTACGCTTTATAGATTccaacatattaaaaatgcataaatgtttattgcaCAATTTAGATGACAAAACtgaaaacaacttttcaaGCTACAATTGCCATTTATGTcctaaaacttttaaaatgagGGGTTCACTTATGGTCCATTTAAGAGTAGCGCACTACGGCTTTTCTTCCCAATCTGACacgacaaaaaaattaaaggatAAAAGTGGAAATCTTGAAACAGAAAGTATACCTACAATACCAGATAGGAGTGATGGGAAACAGTGGCAGTGTGATGTTTGCCGCAAAAGCTTTAcgacaaaatactttttgaagAAGCACAAACGTCTTCATACAGGAGAAACACCGTACGCATGTACACAATGTAACAAAACTTTTACCTTTCAACAATCTTACCACAAACATCTCCTTTATCACAATGATGAAAAACCTCATGTATGTAATTACTGCAATCGAGCTTTTAAGGAATTATCGACTCTACATAACCACCAACGCATACATACCGGAGAAAAGCCGTTTTCCTGTGAAACATGTGGGAAATGCTTTCGTCAACGTGTTTCTTATTTAGTGCATCGCAGAATACACACAGGCGCCATGCCTTATAAATGTACAGCTTGCAAAAAAAGCTTTCGATATAAAGTATCGCAAAGAACGCATAAGTGTCAAGCTCAGCCGCCTGGTACTGTCGTTCGGCAGTCTGGTGATCTAGTAGAAAAACTTAGAAAGAAATGTACAAGCGACCCTGTATCTACTACCAATGAAGGAAATTGCAATAACCTAAATTACAGAGAAATATCTGAGGCTAATGCGGAATTAGTTCGCACTGGAGCAAAATTATCTTTGGAAGACATTGAATCCGAtggtttctctataatatcaGAAGCTTTTACCGAAACTAACCGACGCCACGACGCAATAGCAGATCCTGATTACTCTCGTGTTAATAGTAACGTTACGGAATACAAAAACTACGAAATGTTCGGAGATCATCTCGAAGATTTGATTGACTCTGTACCAATTAATGATAAAAGTATCCCGTCGCCatcagatattttaaaaaacttatgttTGTctaatgatgatgattttgtACTGTGA
Protein Sequence
MSADAASLPCPICLHTGVFNSAQALKDRLIYVSTNNIVCPICQESLSGLDKLTIHLFSHVSLLSPQGLLENEKTEPKSEAKHASHKSHTTTTMKKTRTTAPSKNKVPVTSAPVKFVKIYPKLPVIALNTVPIIDLQSTVDGCVQNNNSMYIQTMKTETTTVKTDHKCNVCGLRFIDSNILKMHKCLLHNLDDKTENNFSSYNCHLCPKTFKMRGSLMVHLRVAHYGFSSQSDTTKKLKDKSGNLETESIPTIPDRSDGKQWQCDVCRKSFTTKYFLKKHKRLHTGETPYACTQCNKTFTFQQSYHKHLLYHNDEKPHVCNYCNRAFKELSTLHNHQRIHTGEKPFSCETCGKCFRQRVSYLVHRRIHTGAMPYKCTACKKSFRYKVSQRTHKCQAQPPGTVVRQSGDLVEKLRKKCTSDPVSTTNEGNCNNLNYREISEANAELVRTGAKLSLEDIESDGFSIISEAFTETNRRHDAIADPDYSRVNSNVTEYKNYEMFGDHLEDLIDSVPINDKSIPSPSDILKNLCLSNDDDFVL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01142625;
90% Identity
-
80% Identity
-