Basic Information

Gene Symbol
topi
Assembly
GCA_956483635.1
Location
OY101447.1:172086755-172091761[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 3.5 3.9e+02 3.3 0.3 2 20 200 217 199 219 0.83
2 11 7.2e-05 0.0082 18.0 2.6 1 23 316 338 316 338 0.97
3 11 0.092 10 8.2 0.3 2 23 370 391 369 391 0.94
4 11 0.072 8.2 8.6 0.1 2 19 454 471 453 473 0.94
5 11 0.49 56 5.9 1.9 1 22 522 543 522 546 0.90
6 11 0.35 40 6.4 0.6 2 23 561 583 560 583 0.82
7 11 9e-07 0.0001 24.0 1.9 1 23 603 625 603 625 0.95
8 11 0.0053 0.6 12.1 1.1 1 23 631 656 631 656 0.95
9 11 0.79 89 5.3 1.7 1 23 662 684 662 684 0.88
10 11 1.1e-06 0.00013 23.7 0.3 1 23 690 712 690 712 0.98
11 11 0.035 4 9.5 3.3 3 23 720 741 718 741 0.96

Sequence Information

Coding Sequence
ATGAATTTAAGTGAAGATTTAAATGCTGATGCTTGGCTTTCGGAGCAATTGTTTGCTCAGCTTAAAGACTTAAACGCTGAATACAAAGACAAAAATACACCGACCGATTTTTTGCTAAGTGAGGCCTTTCAAAACTGTTCCACTAGCATGCCGTTACTGGATGATGTGATTCCTTGGCAGGATTTAAAGCCAACTCCTTTGGATACTTTCGAAACAGTTAACACTTTTTCAAGTAATTACGATATAAATGATGTTTTAGATTTAAGTCAGGCCCACTCGAAAGAACGCCAAATAGAATCGGTGCAGGGAGAAGATAACTTCTTCGGTTTAGTGGAAAACATTCCTTTGACATCGGTCGCTGAACCATATAATGCAGTAAATGAACTGGCGACGAAAATTGAACGGCCTTTATTTGATGCTACCGATGAAGAATTgcaaatattacaatttttagaaaatcaagcAACGGCAGATGTAAAGAGTAGGATATTTATATACatgtttaaattattaatattaccCGCGTACTGGTTTTTAGTTTCAGAAGCTGCTGACCCATCTACACAAGTACTGCCGTTTTCAGCAACATGTGTAATTAAATGTGTAAACTGTAACATCATGTTTAATAACGAGGAATTTGGTGTTCACATTTGTGATAATAATGAAGATCAAATAACGAAAACTACAACAATGGAAATTCCAGCAACGAAAATTAGTACCTCTTGTAATCCTATTAAAGAAGAAAACGACTTGCCTGTTGAACCGGCATGTATTCGTTTATTAAGAGAAAATCAAATCCGCATTAGACGTTTTCTTAAAGAGGAATTAAAGTATGACGTGAGCAGTAGTTTGAATGCATCTGGCTCTACCATCAGCACTATTTCATATGGATCTTTGAATTCATCCAGGGTTTCCGTAAACAGTACTAAGAAACAGGATGGTCCCCATGAATGTACGTTGTGCGAAAGAAAATTTGTCCACGCTTCGGGTTTATTACGTCATATGGAAAAACACGCTTTAGATTTAATTCCCACTTCTAATGTATCTAATAACAAGAGCGCGGCCTTGCAAGGTGCCCAGGGTATTAGTGGATTGCGTGTTGTCATTAAATGTACCCTTTGTGGTCGCATTTTCTTTGAGTCAAACGAAGCattaaatcatttatattcacACTTTCCTGATTCAGTACcagaagaaaaagaaatagaTAATTATGCCGAAATTCCTTATGATGCTTATATAGACGACGCCTACAATAACCTAAAGTCCGAGGTTCAAAGCTTCTACAATCCTACTTCAAGCTACCAAGAGGACAAGACTCCAGTTTATcttaaaattgtaatattaagTTGCATCTTGCAATGTGAATTTTGTGATCTTGTATTTTCCGAAGTGTCATATTTGTTTGTACATTCTGCATGTCATTTACCTTCTAGAAGATTTGAGTGCTTTGCTTGTGATATTCATGCAAGAACATCGAAAGAAATTTGTAATCATTGGCATGCTGAATGTGTTTTTATGCGTGAAAATTTAAAGATTCATCAGGCAACCACTCAACGCTATTTTGTTTGTAATGTATGTGAGAATAAATTTCAGTCTATGGATTTATTGCATGAGCATCGTTATACATCGTACCATTTTTTTCCACGGCTTAACAAAAGCACTGGTACATTACAATTACCCTGTGAATATTGCGAAAGAGTTTTTGAAACCGCCCAAGAATGTGTGAATCACTACGAAGAAAAACATTATAGGAAATATAAACGTGATAGAGATGGAAATAATGTGTCTAGTAAGACCAGACAATACTTGTGTGATATATGTGGTAAATCATATACTCAATCCAGCCATTTATGGCAGCATTTAAGATTTCATCAGGGAGTAAAACCATTTGCATGTAAAGAACCAGGTTGCACCAGAAAATTTACAATACGTCCGGACTTAAACGATCACATACGTAAATGCCATACTGGTGAAAGACCTTACCATTGTCTAGTATGTGGAAAACGATTCCTTACAGGTTCGGTTTTTTACCAACATCGTCTCATACACCGTGGCGAAAGGCGTTACGAATGCGAAGCATGTGGCAAACGTTTCTATCGTGCCGATGCATTGAAGAATCATCAGCGTATTCACACCGGTGAAAAACCATTTGGATGTCACTTTTGTACTAAAAACTTTAGACAACGAGGAGATCGTGACAAGCATATACGAGCCCGACATTCTCATCTGGATGCAAATGCTCGTCTTATGatgcaaatgcaaaaattacaaTTGGAAGCCGCAGCAGCACAGGTTGGGGACCCACAGAAATTGGATATTACAACAAATTATCAGGATTATATGTCCGTTGGTAATGAAAATATACCACCCCCAGACTATATGTCTGGTAGGAATAATAGTCTCAATGATATTTTCACGATTGGCAATTTagagttttccaaaaatatttttgagtccTTAATGTCtgatataattaattaa
Protein Sequence
MNLSEDLNADAWLSEQLFAQLKDLNAEYKDKNTPTDFLLSEAFQNCSTSMPLLDDVIPWQDLKPTPLDTFETVNTFSSNYDINDVLDLSQAHSKERQIESVQGEDNFFGLVENIPLTSVAEPYNAVNELATKIERPLFDATDEELQILQFLENQATADVKSRIFIYMFKLLILPAYWFLVSEAADPSTQVLPFSATCVIKCVNCNIMFNNEEFGVHICDNNEDQITKTTTMEIPATKISTSCNPIKEENDLPVEPACIRLLRENQIRIRRFLKEELKYDVSSSLNASGSTISTISYGSLNSSRVSVNSTKKQDGPHECTLCERKFVHASGLLRHMEKHALDLIPTSNVSNNKSAALQGAQGISGLRVVIKCTLCGRIFFESNEALNHLYSHFPDSVPEEKEIDNYAEIPYDAYIDDAYNNLKSEVQSFYNPTSSYQEDKTPVYLKIVILSCILQCEFCDLVFSEVSYLFVHSACHLPSRRFECFACDIHARTSKEICNHWHAECVFMRENLKIHQATTQRYFVCNVCENKFQSMDLLHEHRYTSYHFFPRLNKSTGTLQLPCEYCERVFETAQECVNHYEEKHYRKYKRDRDGNNVSSKTRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFACKEPGCTRKFTIRPDLNDHIRKCHTGERPYHCLVCGKRFLTGSVFYQHRLIHRGERRYECEACGKRFYRADALKNHQRIHTGEKPFGCHFCTKNFRQRGDRDKHIRARHSHLDANARLMMQMQKLQLEAAAAQVGDPQKLDITTNYQDYMSVGNENIPPPDYMSGRNNSLNDIFTIGNLEFSKNIFESLMSDIIN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01177337;
90% Identity
-
80% Identity
-