Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.056 3.6 9.2 2.2 2 20 160 180 159 182 0.83

2 5 0.023 1.5 10.4 0.5 1 12 190 201 190 204 0.88

3 5 5.3e-06 0.00034 21.9 2.7 2 23 210 231 209 231 0.96

4 5 2e-06 0.00013 23.2 3.6 1 23 237 259 237 259 0.97

5 5 2.5e-05 0.0016 19.8 5.5 1 23 265 287 265 287 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.056	3.6	9.2	2.2	2	20	160	180	159	182	0.83
2	5	0.023	1.5	10.4	0.5	1	12	190	201	190	204	0.88
3	5	5.3e-06	0.00034	21.9	2.7	2	23	210	231	209	231	0.96
4	5	2e-06	0.00013	23.2	3.6	1	23	237	259	237	259	0.97
5	5	2.5e-05	0.0016	19.8	5.5	1	23	265	287	265	287	0.96

Coding Sequence: ATGGCggatattgaaaataaagacAATGAAATAAATCCAAGACGATGTCAcatgaaaattgaaattgatgaagAAGATTTAAGTGTTTTTGACAAAAGTATGGTAAAAATAGAATTGAAAGAAGAAGTCTTAGAAAATAATGAATTGACAATAGCCAAGAGAGAAGATATTTTGTGTGACGTAAAAAGCGAAATGGATAAAGATTCTAGAAATTTCTTGTCTCTAGAGTGTAAATCAGATAGACCTTCGGATATGTCTGACACTAAAGACAACGACTGTTCTCCATCAGCGCTACCTGACTTGTCAAGTTCCAGTGAGATACCTGAAGAACAATCACAATCTGCAACTGATATCCAACTAAATGAATTACATGACAGTACTAGAAAAGAAACAAGTTTTGTCTGTGTCGTATGTTGTAAGGAGTTTTCGACGAGTATTCTAGACAATCAAATATTGGAAGGTAATGGAAAACCTTGCACATGTGGAATAAATGGTTGTAATAAATGCTTTTCTAGAAATAAATTGTTACCTAATCACGCAAATAGTGAGCAACCCGTGAAAAATAGGTATTCTTGTAACGATTGTACTAAATCTTTTAAAGTTGCACATGCTGAAGGTAAACTGTGGTCATGTGATGAATGCCATAAATCGTTTAAACGAAAACAAGCCTTGGAAAGACATAAAGTTACACATGCTGAAGGTAAACCATATTCATGTGATGAATGCCATAAATCGTTTAAACGAAAACAAGCCTTGGAAAGACATAAAGTTACACATGCTGAAGGTAAACCATATTCATGTGATGAGTGCCATAAATCGTTTAAACGAAAACATTATTTAATCCAGCATAAAGTTGTACATACTAAAAAGAAACCATGTTAA
Protein Sequence: MADIENKDNEINPRRCHMKIEIDEEDLSVFDKSMVKIELKEEVLENNELTIAKREDILCDVKSEMDKDSRNFLSLECKSDRPSDMSDTKDNDCSPSALPDLSSSSEIPEEQSQSATDIQLNELHDSTRKETSFVCVVCCKEFSTSILDNQILEGNGKPCTCGINGCNKCFSRNKLLPNHANSEQPVKNRYSCNDCTKSFKVAHAEGKLWSCDECHKSFKRKQALERHKVTHAEGKPYSCDECHKSFKRKQALERHKVTHAEGKPYSCDECHKSFKRKHYLIQHKVVHTKKKPC

Sequence clustering based on sequence similarity using MMseqs2