Basic Information

Gene Symbol
ZNF423
Assembly
GCA_963854515.1
Location
OY978014.1:13655115-13668435[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 0.66 44 5.5 0.1 2 23 117 138 116 138 0.95
2 17 0.025 1.7 10.0 0.2 2 23 142 164 141 164 0.90
3 17 2.2 1.4e+02 3.9 2.7 3 23 169 190 167 190 0.93
4 17 2 1.3e+02 4.1 2.2 2 23 399 421 398 421 0.95
5 17 0.1 6.6 8.1 0.0 1 20 429 448 429 450 0.94
6 17 0.03 2 9.8 0.9 3 23 461 481 460 481 0.96
7 17 0.027 1.8 9.9 5.4 1 23 529 552 529 553 0.93
8 17 0.25 17 6.9 0.3 3 23 629 650 627 650 0.85
9 17 4.7e-05 0.0031 18.6 1.9 1 23 684 706 684 706 0.97
10 17 2.1e-05 0.0014 19.7 1.5 1 23 713 735 713 735 0.98
11 17 0.00012 0.008 17.3 2.3 1 23 740 762 740 762 0.96
12 17 0.00024 0.016 16.3 0.3 3 23 770 790 768 790 0.98
13 17 4.3e-05 0.0029 18.7 1.1 1 23 796 818 796 818 0.94
14 17 0.00044 0.029 15.5 2.6 2 23 825 846 825 846 0.98
15 17 0.00049 0.032 15.4 0.6 2 23 855 877 854 877 0.97
16 17 0.0049 0.32 12.2 0.2 2 23 883 904 882 904 0.94
17 17 0.095 6.3 8.2 4.0 1 23 910 933 910 933 0.98

Sequence Information

Coding Sequence
ATGTCTTCTGAAGAGTCTGACGATGAACCCCTCGCGATGATAGCGGCTGCAAAGAAGTCTAATCCGGGAAAATATGCAGATGAACTTGAGGTTCTGTGCAAAGATGAAGCGGctcaaagaaaaaagaagaaaatagttCCCCAGAAGAAAATGTCAGCTATGACGATTAAGATTAACCGTGCTTTGAAGGCTGTAATCAACCCGCCGGTCGTCGAGCGGCCCATGGACGTGTGGCTCTACTTAAAAGACCTGAATCCAACAGGGCCGTATAGTTGTTTACTTTGCTCTAATTGGTTCATTAACAGGGGTAAAATGATTGTACACTACATATTAAATCACAAAAAAGACTATTGTGGGATCTGTAGATATTTTGTACCTGACAGAGAGTCCTGGTTTGCGCACCTTAAATTCCACATACCATGGCCTTGTTCTCAATGTGTTAAAAACTTTGAAACAGAGGGAGAGCTCCGTCAGCATTTTAGCTTAGAACATAACTTGGTGCACTGCCGACTGTGCCACTTTCGAGTAGCCGATAATGACCAGTACAACACTCATTTGATACAAAAACACAGTGTCTCTAACTTGACTAGCAAAGATGAGGAATTGTGGCAGTTTGAGTATGAAGGCAGTAATAAATTCCTCTGTTTGCTTTGCTCCAAGTCTAACAACCTGTGTAATATGTTCTTTAACCACTACATGGGATATCACCATTTCACTCTCAAGTGTCTCAGCTCGTTGCTCTCGGGGAGAGATGTACCGTTTACAGTCAATGGTGCTGAAATCAGTCCTGCATTTATTGAAGGGGAACTTAAAGATCACAGCAGAATTGGTTACGTTGACTTGGAGAGCAAACCCCCTGAAATAACAAATGAAGAAGAACATAGCGACAATGAAACACAGGATCTACTTAATGTTCTCATACCTGAAATCAAGCAGGAAGCTACGAGTGAACCAGAAGACGCTCCTGATGACAAAATAAAAGACAAAAAGAAGAAAGTAAGAGACGAAAATGACATTGCCAATATATACAAGGGTGATGAAGATTTTGATGTCACATTAACAGAGTTGATTATACTAGAGAAATGTTACTTTGAATATGTGAACCAGACATTAAAGGATATTGACTCGAACTTGGTACCGGTGTGTGGTATAGATTATTCTGCCTTGAAGCCTGACGTACCAACAATTGATATACCATGTTCACTTTGCAAGAACAAGTGCAACAATATTCAGTCATTTATGTCTCACATGATAAAAAATCATTTGATGAAGACAGCACCGATTTACTCTTGTCGTGTTTGCGCTACTACATTTGAAAATCAGACCGAGTTGGATAGTCATGTTGCAGAAGAGTTGGGGGactttgacgatctgtggttatgtcagttttgtgacaaaGAATTCGACAACAGAGAAGCTACGAGGAAGCACTTGACAGAGCACTGGAATGTCATGGAGTCGGACAACTGTTACAGTCCACATTTGGGATTCAAATGTAAATTTTGCCCGTCACTGTTTTGGAATGAAACAGATAGAGAGGCGCATCAGGTTCACGTACATTTGAACCAACACAAGGAGCAGTTTTACAAATGTGAAGATTGCTCTCAAACCTTCAGTGACAAGATATTCTTTATTCACCACTTCATGGAGAAGCATCACTCCCCTCTCCGACCCTCGTATCTGCTCAAATGCAGCATCTGCTGCGTGGTGCGGTCTACTGTGGAGGAGATGAGAGCGCACTTCCAGGAGAAACATCCTGATGCGAGAAAAGTGTTCTGCTCTATGGACGCCTGCCAGTATAGACCACTGAGTCACAGGAAATCTTTTAAATTCCATTTGAGGACGGTGCACGATCCGACGGTGCGTCCGCAGCGCTCGGTCAACTGTACCGTGTGCGGGCGGGAGTTCGTGAGCTCCCGGGCCTGCGGGGCCCACATGGCGCAAGTCCACGGCCCGGGCAAGTTCAAGTGCAAGCTGTGCCGGGAAGTCATGCACACCTTGGATGAGAGGAAGCTGCATTACCTTCTGCGGCATCCAGGCCGTCACCCATTCGAGTGCACCGAGTGCGGCAAGTCCTTCCAATACAAGTCGTCGCTCTATATGCACAAACAGGAGCACTCGCCGAACAAACAGAGCTACACCTGTTCCTATTGCTCCAAAGTTTTTGCGAAACGCGACTCGTTCCGCGAGCACCTCCAGATACATGAGGGCCCGCGGCACGCGTGCTCGTACTGCCCGATGCGGTTCGTGCAGCGCTCCAACATGCTGCGGCACGAGCGGCGGCACACGGGCGAGCGGCCCTACGGCTGCCCGCACTGCCCGCGCACCTTCGCGGACAAGGGCGCGGCCACCTCGCACGCCAGAACACATTCCAAGGAAGCCTCCTACGCTTGTATTTACTGCGGACAGACGTTTGTTCAGAAATCGAAGCTGACATATCATATCAGAAAACATACAGGGGAGAATCTGGAAACGTGTACGATTTGTTCGAAGTTGTTCACTAGCGCTTGTTCCTTGCGGGAACACATGAAAATACATCTGGCTAAGAAAAAAGAGGCTGTCCAGTGCCCGCTGTGCGACAAGAAATACCAAGACGAGCGTTACATGCTCCGTCACCTCCGTACCTCGCACACGCGCACGCAGCTGCCGTGTCCGCTGTGCGACAAGACGCTCACCAGCATGGCGGGCTTGCGGCACCACGTGGTGTCCCACAGCGGCCTCAACACCTTCAAGTGTAAATGCTGCCCAAAATCCTACGCCGTGAAACGGTCCGTCGTAAAGCATCTTAGGAAACGCCACAGTCTGAAAGGGACAGAGATAAACATCAAGGATTACTTCAAACGAATAGACCCACGGGATTGCAACCTCGCGCTCGACGAAGAAGCCATGACGCGTATATTCGGCCCACCAAAGAAGAGAATGAGCGACATCCTCATTGGTGACTTTGTAACGCTTAGGAAAAACTTAAACTTCCCTAACGCACAGAAAGACGGTAACGACGATGACGACAACGACGACGATGAAGATAATGAAGGAAATGACAATGACGAACAATCCGATGACGATGAGAATGAGAATGCGAATGAAACAGTTGAAGAAATTAAAgaagttattataaaaacagAGAAGAGGGATGATGAATTGGAAGCCACCGATTTTGTTAGTGTTAAGATTGAACCCATGGATGAGGAAGATGAATAG
Protein Sequence
MSSEESDDEPLAMIAAAKKSNPGKYADELEVLCKDEAAQRKKKKIVPQKKMSAMTIKINRALKAVINPPVVERPMDVWLYLKDLNPTGPYSCLLCSNWFINRGKMIVHYILNHKKDYCGICRYFVPDRESWFAHLKFHIPWPCSQCVKNFETEGELRQHFSLEHNLVHCRLCHFRVADNDQYNTHLIQKHSVSNLTSKDEELWQFEYEGSNKFLCLLCSKSNNLCNMFFNHYMGYHHFTLKCLSSLLSGRDVPFTVNGAEISPAFIEGELKDHSRIGYVDLESKPPEITNEEEHSDNETQDLLNVLIPEIKQEATSEPEDAPDDKIKDKKKKVRDENDIANIYKGDEDFDVTLTELIILEKCYFEYVNQTLKDIDSNLVPVCGIDYSALKPDVPTIDIPCSLCKNKCNNIQSFMSHMIKNHLMKTAPIYSCRVCATTFENQTELDSHVAEELGDFDDLWLCQFCDKEFDNREATRKHLTEHWNVMESDNCYSPHLGFKCKFCPSLFWNETDREAHQVHVHLNQHKEQFYKCEDCSQTFSDKIFFIHHFMEKHHSPLRPSYLLKCSICCVVRSTVEEMRAHFQEKHPDARKVFCSMDACQYRPLSHRKSFKFHLRTVHDPTVRPQRSVNCTVCGREFVSSRACGAHMAQVHGPGKFKCKLCREVMHTLDERKLHYLLRHPGRHPFECTECGKSFQYKSSLYMHKQEHSPNKQSYTCSYCSKVFAKRDSFREHLQIHEGPRHACSYCPMRFVQRSNMLRHERRHTGERPYGCPHCPRTFADKGAATSHARTHSKEASYACIYCGQTFVQKSKLTYHIRKHTGENLETCTICSKLFTSACSLREHMKIHLAKKKEAVQCPLCDKKYQDERYMLRHLRTSHTRTQLPCPLCDKTLTSMAGLRHHVVSHSGLNTFKCKCCPKSYAVKRSVVKHLRKRHSLKGTEINIKDYFKRIDPRDCNLALDEEAMTRIFGPPKKRMSDILIGDFVTLRKNLNFPNAQKDGNDDDDNDDDEDNEGNDNDEQSDDDENENANETVEEIKEVIIKTEKRDDELEATDFVSVKIEPMDEEDE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00411840;
90% Identity
iTF_00342542;
80% Identity
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