Basic Information

Gene Symbol
ZNF526
Assembly
GCA_963854515.1
Location
OY978035.1:8276734-8283691[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 0.00014 0.0095 17.1 1.5 1 23 427 449 427 449 0.98
2 18 1.3e-05 0.00084 20.4 2.4 1 23 469 491 469 491 0.98
3 18 0.0024 0.16 13.2 1.1 2 23 514 536 513 536 0.95
4 18 0.39 25 6.3 0.6 1 21 541 561 541 562 0.94
5 18 0.02 1.3 10.3 0.4 1 21 635 655 635 656 0.94
6 18 5.9e-06 0.00039 21.4 1.5 2 23 663 684 662 684 0.97
7 18 0.0025 0.16 13.2 0.9 1 23 690 713 690 713 0.96
8 18 1.4e-05 0.00095 20.2 3.8 1 23 719 741 719 741 0.98
9 18 0.00069 0.045 14.9 1.6 1 23 750 772 750 772 0.98
10 18 5.4e-05 0.0036 18.4 1.2 1 23 778 800 778 800 0.97
11 18 0.0007 0.047 14.9 0.6 1 23 806 828 806 828 0.98
12 18 3.5e-05 0.0023 19.0 2.0 1 23 834 856 834 856 0.98
13 18 3.1e-06 0.0002 22.3 4.2 1 23 862 884 862 884 0.98
14 18 0.0002 0.013 16.6 0.2 1 23 890 912 890 912 0.97
15 18 1.5e-05 0.001 20.1 0.8 1 23 918 940 918 940 0.98
16 18 2.8e-05 0.0019 19.3 2.5 1 23 946 968 946 968 0.99
17 18 0.00089 0.059 14.6 4.0 1 23 975 997 975 997 0.98
18 18 0.011 0.73 11.1 0.1 1 23 1003 1025 1003 1025 0.97

Sequence Information

Coding Sequence
ATGACTTCGGATTTGAGTGATTTGGTGAAAGAGGAGGCGGCGTGGGAGGCCGAGTACGTGGAGGCGCTGTGGGCGGCGCTGTACTCGGGCCGGCAGGAGCCCCGGCCGGGGCCCGAGGGGAGCTCCGAGAGAAATGCGGCAGAAGACTTCGCGTTGCCAGCTTCAAGAGTATGTGCCACAAACACCAGCCACCTTCAAACCAAGACGAAAGCAACAGAAGCCATACGAGACCCCGAAGATGCTACCACCACCCACCCTAGACCTAAAGATACCACGTCCACCATAATGCCAAAGACAGAAACCGAACAGAGTACAGCTGACATTACTACCAGCTCTGAAGACTGGTGTATTAGTAATACGCCCAAGACAGAAGTAGCACCACTTAGTAATGTTCCTACTACCCACCCTAGCCTTAAAGATACTACAGCTAGTATAACGCCAATGACAAAAGCAACACAGAGCTCTGCAGACAATACCAGCTCTGAAGACTGGTGTATTGGTAGTACGCTCAAGACAGAAGTAGCAACAGTTTGCAATGTTCCTACTACCCACCCTAGCCTTAAAGACACTATTTCCAATATAACGGCAACGACAAAAATAATACAGAGCCCTACAGACATTACCAGCCCTGAAGGCACTAGTGCTAGTAATACGCCTAGAACACAAGTAGCACCAGTTCTTAGCAATGTTCCTACTACCCAGTCTGGTATCGACACTACTGCTAATATAACGCCAAAAATAGAACCAGTATGGACCACTGAAAATACCAGTACTACTGATACGCCTAGAAAAGGAGAAGCACCAGTTCTTAGCAATGTTCCTACTACCAACCCTAGCCTTAAAGACACTACGGCTAATGCTGTAATTCAGAGCCCTTCAGACATTACCAGCCCTGAAGGCATTAGTGCTAGTAATACGCCTACAACAGAAGTAGCACCACTTAGCAATGTTAATTCTACCGAGTCTAGTCTTGACACTACTGCTAATATAACGCCAAAGATAGACCCAGCATGGACCACTGGAAATACCAGTACTACTGATACGCCTAGAACAGGAGTAGTACCGGTTCTTAGCAATGTTTCTACTGCTCACTCTACCCTTGAAGAGCACGGTGGTAGTAATGTGCCTCGGTCAGAAGTAGCACAGAACACAGATGTTTCTGGCACTCAAACTAGACAAGAGCCTAGTGTTAGTAACAGATCTAGTTTTTACAATTATGATGCAGGCTCACTAAAACCCTGTTACATTAAGTTGGAACACATTCCCTACAAGAATGCATTCGTATGTCCGGTATGCCCAAAGGTATGCGGCTTCAAGCATAACCTTAGGATGCATCTTCTCGTTCATACTCAAGAAGAAATTAAGACGATCAAAATTGAGAAGAAAGTTATGAAGAAAGGGAAATTCAAGTGTCATATTTGTGGACAGGGATTGACAACAAAACAGCAACTAACTAAACACCTGAAAATACATACAAGAGATCCGTTCTCGGAGCAAATacgtataaaaaaacaatatcacATTACGAAGACGTATTTAGAATGTGACGACTGTGGAATGAAGACATTAAGAAAGACGAGTCTGTTAAAGCATATGCGGAGGTTCCATAGAGACGGGAGCTTCGCATGCCAAGTTTGCAAGCAACAGTTCAGAGCTGCGTGCAAGCTGTTGGAACACATAAAGCTTGCAGCTTGCGAGCAAACAAAAGAAATAGTTGGACCACAGTCTGATGAGGCCGTCTTGAATGAAATGCTGAAATCCTGCTTTGTTAAACTTGAACGCGTTAATATTGGAAAAGGGAAGGCTATAATGAAGATAGTTGATGAAACTACGAACAGTAACAGTGAGGATGACAATTCTGTTAGGAAGGATCATTCCGCTTTTCAAACTGATGAAGAGACATACTATTGCGGCGTTTGCGAGGAGCAGTTTGTATCGTTGTCATCGTTAAGCGACCATGTTTGCCGTCGTCCCAAGAAACGGGTCTCGTGCGATATTTGCGATAAGAGGTTCAGAAAGACCTCACACTTAATCGAACACCTTCGGATTCACTCAGGCGAGAAACCCTTTGCGTGTGACGTGTGTAAAAAACGATTCCGGCTGAAACTTACCATGAAAACGCATATCATAACTGTGCATTTGCGTGGGATGGCTTACTCGTGCAAATTGTGCAAGAAAAAGTTTCGCAGCGCTTTCTCATTGCGGAAACATGTTCGCAGTCACACAGGGGAGAAGGAAATAAAACGGTATTCGTGTAAAGTGTGTAAGAAACGGTTCAGGAACAACCGGGAGCGTGTGGAGCACGCCCGCGTCCACACCGGCGAGAAACCGTACGTCTGCAAAGTGTGCGACAAGGGATTCCGTGTGGAATCCGATCTGAGGATCCATAATCGCCACCATACCGGAGACAAACcgtattcgtgtgatgtgtgcAAGAGAAGGTTTCGTATTTGGCAGACGTTGGACGCTCACAAACGCGtgcacacaggtgagaaaccgttTACGTGTGACGTATGCAAGAAACGGTTCAGACGGTATGATACGTTGGCTACGCACAGCCGGATACACACAGGGGAGAAACCGTACGCGTGCGAGTATTGCCCGAAGAAGTTTACACAGAGAAGTCATTTGAGCACCCATACGAAGACGCACACAGGTGAGAAAAATTTCATTTGTGTGGTGTGTGATAAAAGGTTTATCGAGAGATCCGCATTGAAGCTACACAGCCGTGTCCACACGGGTGAGAGACCGTATGCGTGTGATGTGTGTAACAAAACCTTTAAAGCCAGTGGGGACCTGAAAACCCATAAACGTTCTCACACGGGCGAGAAACCATACGAGTGTAAAGTGTGCAAGAAGTTATGCGCTCAGGCCTCGAATTTGAGTACGCATATGAAGACGCACGGTAGGAAGAGCCAGCCGTTCAGTTGTCATGTGTGTGAGAAGAGGTTCCAGAGCCGCACGTCTTTGGATAAGCATTTGAAGCTGCATGATGCGCGTGCGGCGCATATGTGCGACGTGTGCGGTGCGAGGTTCGCGAGCGACAGTGTTCTAAGCGCGCACGCTCTGACGCACGCTGGATGTGATTGA
Protein Sequence
MTSDLSDLVKEEAAWEAEYVEALWAALYSGRQEPRPGPEGSSERNAAEDFALPASRVCATNTSHLQTKTKATEAIRDPEDATTTHPRPKDTTSTIMPKTETEQSTADITTSSEDWCISNTPKTEVAPLSNVPTTHPSLKDTTASITPMTKATQSSADNTSSEDWCIGSTLKTEVATVCNVPTTHPSLKDTISNITATTKIIQSPTDITSPEGTSASNTPRTQVAPVLSNVPTTQSGIDTTANITPKIEPVWTTENTSTTDTPRKGEAPVLSNVPTTNPSLKDTTANAVIQSPSDITSPEGISASNTPTTEVAPLSNVNSTESSLDTTANITPKIDPAWTTGNTSTTDTPRTGVVPVLSNVSTAHSTLEEHGGSNVPRSEVAQNTDVSGTQTRQEPSVSNRSSFYNYDAGSLKPCYIKLEHIPYKNAFVCPVCPKVCGFKHNLRMHLLVHTQEEIKTIKIEKKVMKKGKFKCHICGQGLTTKQQLTKHLKIHTRDPFSEQIRIKKQYHITKTYLECDDCGMKTLRKTSLLKHMRRFHRDGSFACQVCKQQFRAACKLLEHIKLAACEQTKEIVGPQSDEAVLNEMLKSCFVKLERVNIGKGKAIMKIVDETTNSNSEDDNSVRKDHSAFQTDEETYYCGVCEEQFVSLSSLSDHVCRRPKKRVSCDICDKRFRKTSHLIEHLRIHSGEKPFACDVCKKRFRLKLTMKTHIITVHLRGMAYSCKLCKKKFRSAFSLRKHVRSHTGEKEIKRYSCKVCKKRFRNNRERVEHARVHTGEKPYVCKVCDKGFRVESDLRIHNRHHTGDKPYSCDVCKRRFRIWQTLDAHKRVHTGEKPFTCDVCKKRFRRYDTLATHSRIHTGEKPYACEYCPKKFTQRSHLSTHTKTHTGEKNFICVVCDKRFIERSALKLHSRVHTGERPYACDVCNKTFKASGDLKTHKRSHTGEKPYECKVCKKLCAQASNLSTHMKTHGRKSQPFSCHVCEKRFQSRTSLDKHLKLHDARAAHMCDVCGARFASDSVLSAHALTHAGCD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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