Basic Information

Gene Symbol
tfap2e
Assembly
GCA_963854515.1
Location
OY978027.1:5532880-5550827[+]

Transcription Factor Domain

TF Family
AP-2
Domain
TF_AP-2 domain
PFAM
PF03299
TF Group
Basic Domians group
Description
Activator protein-2 (AP-2) transcription factors constitute a family of closely related and evolutionarily conserved proteins that bind to the DNA consensus sequence GCCNNNGGC and stimulate target gene transcription [PMID: 2010091, PMID: 1998122]. Four different isoforms of AP-2 have been identified in mammals, termed AP-2 alpha, beta, gamma and delta. Each family member shares a common structure, possessing a proline/glutamine-rich domain in the N-terminal region, which is responsible for transcriptional activation [PMID: 2010091], and a helix-span-helix domain in the C-terminal region, which mediates dimerisation and site-specific DNA binding [PMID: 199812]. http://www.ebi.ac.uk/interpro/entry/IPR013854
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 7 2.8e-24 8.4e-20 72.2 0.1 1 46 34 79 34 82 0.97
2 7 1.9e-10 5.8e-06 27.0 0.3 21 46 83 108 80 111 0.94
3 7 2.9e-10 8.7e-06 26.5 0.0 21 44 112 135 110 140 0.94
4 7 6.4e-11 1.9e-06 28.6 0.1 22 46 142 166 139 169 0.94
5 7 3.3e-10 1e-05 26.3 0.0 21 44 170 193 166 197 0.94
6 7 3.6e-10 1.1e-05 26.1 0.0 21 44 199 222 195 227 0.94
7 7 1.6e-67 4.8e-63 213.3 0.0 21 196 228 400 225 401 0.96

Sequence Information

Coding Sequence
ATGGATGACACGACAGGGTTCATGACTGACCTTCCTTTATtaaaaaCGATAAAAGGCCGAGACGGACTCGGCGGCGGCTCCTGCACACCCAACGACGTATTCTGCTCCGTCCCGGGACGACTGTCACTCCTATCGTCGACCAGCAAATACAAAGTGACCGTAGCGGAAGTGCAGCGTCGCCTGTCACCGCCGGAGTGTCTCAACGCGTCGCTGCTCGGCGGCGTACTACGGCGCGAATACAGTGACGTAACTGAAGTGCAGCGTCGCCTGTCTTTGCTGGAGTGTCTCAACGCGTCGCTGCTCGGCGGCGTACTACGGCGCGAATACAGTGACGTAACTGAAGTGCAGCGTCGCCTGTCCCCGCCGGAGTGTCTCAACGCGTCGCTGCTCGGCGATGTGCTACGGTACGAATACAGTGACATAACCGAAGTGCAGCGTCGCCTGTCCCCGCCGGAGTGTCTCAACGCGTCACTGCTCGTCGGCGTACTACGGCGCGAATACACTGACGTAACTGAGATGCAGCGTCGCTTGTCCCCACCGGAGTGTCTCAACGCGTCGCTGCTCGGCGATGTGCTGCGGTGCGAATACAGTGACGTAACTGAAATGCAGCGTCGCTTGTCCCCACCGGAGTGTCTCAACGCGTCGCTGCTCGGCGATGTGCTGCGGTGCGAATACAGTGACGTAACTGATGTGCAGCGTCGCCTGTCTCCGCCGGAGTGTCTGAACGCGTCCCTACTCGGCGGCGTGCTGCGGCGAGCAAAGAGTAAAAATGGCGGTCGCCTGCTTCGAGAGAAACTGGAAAAGATAGGACTGAACCTGCCGGCGGGGCGACGGAAAGCTGCCAACGTCACGCTACTCACCAGCCTAGTCGAAGCGGAAGCGGTGCACCTAGCCCGTGACTTCGGCTACGTGTGCGAGACGGAGTTccctgcgcgcgcgctggccgagTACCTCGCGCGGCAGTACGCCGAGCACgacgcgcgccggcgccgcgaccTGTTGCAGGCCACCAAACAGGTGACCAAGGAGCTGATGGACCTGTTGAACCAGGACCGCTCGCCGCTCTGCAACACGCGGCCCCCGCACCTCCTGGAGCCGGCGATACAGCGGCACCTCACGCACTTCTCGCTCATCTCGCACGGCTTCGGCGGGCCGGCCATCGTCGCCGCGCTCACCGCCATACAGAATTTCCTAAACGAGTCCCTGAAGCATTTAGATAAACTATATCCCCAAAGCGGCATGGTGTCGTCATCGATGGACAAGACCAAAATGGACCCCGACATCAAGAAGTAA
Protein Sequence
MDDTTGFMTDLPLLKTIKGRDGLGGGSCTPNDVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRREYSDVTEVQRRLSLLECLNASLLGGVLRREYSDVTEVQRRLSPPECLNASLLGDVLRYEYSDITEVQRRLSPPECLNASLLVGVLRREYTDVTEMQRRLSPPECLNASLLGDVLRCEYSDVTEMQRRLSPPECLNASLLGDVLRCEYSDVTDVQRRLSPPECLNASLLGGVLRRAKSKNGGRLLREKLEKIGLNLPAGRRKAANVTLLTSLVEAEAVHLARDFGYVCETEFPARALAEYLARQYAEHDARRRRDLLQATKQVTKELMDLLNQDRSPLCNTRPPHLLEPAIQRHLTHFSLISHGFGGPAIVAALTAIQNFLNESLKHLDKLYPQSGMVSSSMDKTKMDPDIKK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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