Basic Information

Gene Symbol
ZEB1_1
Assembly
GCA_949127965.1
Location
OX421878.1:922657-934537[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 8.8e-05 0.0057 17.7 2.3 1 23 219 241 219 241 0.98
2 12 0.29 19 6.6 0.1 1 23 248 271 248 271 0.94
3 12 4.9 3.2e+02 2.7 4.2 1 23 275 297 275 297 0.93
4 12 0.002 0.13 13.4 1.6 1 23 302 325 302 325 0.96
5 12 0.2 13 7.1 0.3 3 23 331 352 330 352 0.96
6 12 0.0078 0.51 11.6 0.0 3 20 365 382 364 384 0.94
7 12 0.0016 0.11 13.7 0.0 3 23 397 417 396 417 0.96
8 12 0.001 0.067 14.3 1.4 2 23 424 446 423 446 0.96
9 12 2.8e-05 0.0018 19.3 0.7 2 23 463 484 462 484 0.97
10 12 1.6e-06 0.00011 23.1 0.8 1 23 490 512 490 512 0.99
11 12 2e-05 0.0013 19.7 3.9 1 23 518 540 518 540 0.94
12 12 3.4e-06 0.00022 22.1 2.5 1 23 546 569 546 569 0.98

Sequence Information

Coding Sequence
ATGGAGAAATTACTTGCATGCCGCGTATGCTTAATTACGGATGCTAAATTGTACGATATGTACAAATATTCGTTAGTACAGGCTTATGAAATTCTAACTGGAATGCAGATAACAGCAGATGGCCTACCTGTACATATGTGTAGTATGTGCGCCACTTTATTGAATAAATCCGCATTATTCAAGGCGAAATGCGAAACTGCTCAACAAATATTCAAATATGCATTAACTCAACAGGATACGTTACCAACAACATACATAAGAACTATAGACCGTAATCTACATGCTCTCACTCTTCCGTTCACTGTGACAACAACATTTCAAGCCACAGATGACAGTACGGACATCAAAGAAGAAGACATAGACACAGACTTCATAGACAATATAGATAGCTTAGACAATATAGAAGTGAAATACGAGTCTGACGAAGAACCTCTAGcgaagaaagttaaaaaaaagcgAAAGAAGAAAATCCAAGATAAAGTTGCGGATGAAAAGGAAAATgatgattttaaatttgatgttGATACGGATAAAGTAATGGATGATGTTAATGTGGATGGCTTGAACGATATAGAGATTGTGGTTCTGAGCAAGGAGCAGCAAATAAACGAGGTGGTGTTGAGGAAGAGCTCTTTCAATTATTTGAATTCGTTCTACAAGTGCGACAAGTGCTTCAAGGGTTTTATAACGGATTCTACGTTCAAGAATCACATGGCCCGGCATGCTGTGGTGAGCGGCGCTCATGTGTGCGAGGTGTGCCAGACGCGCTGGGCCAGCGCACGCGCACTGCGGGCACACGTGGTGACGTCGCACGAGCGGAAGTACGTCTGCCGGAAGTGCGATCACGTATCCAAGTCCAGccATCGAGCGAAAGAACACAGCAAATGGCACCTCGGCTTCACATATGTGTGCAAAATATGCGGAGCGTCGTTCACCAAATCCACGAGTCATCTCACTCATATACGTCTGCAGCATCCGTCTGACAACTGCTGCGAGTTGTGCGGCGACTCCTTCATAGGGGAGTACGGTCTTGCGATGCACAGGAAGAAGGCGCATAGAGACGAGgATGGTAAAGTGAAGTCTGAATCGCTATGCGTGCTTTGCGGAGTACAGTTTAGGAGTTTAGACGCCCTGAACAGACATATAAGCGCGGCTGAAGACAACACATGCAATCCTGAATTGAGGCCTTGCTTGTCCTGCGGCGAAGGTTTCGTCTCCGAAGAATCCCTGAAGGACCACCTGAAGGTCCACATCAAAGATGACAACGTCAAATGCGAACAGTGCAACCGCACGTTCGCGCACGAGAAGTCCTACGCGATCCACTACCAGCGCGTGCATCTGCGCGTGAAGGCGGGCGGCCGCCGCGAGATGTGCACCGACCGGGTCGTCTGCGAGATATGCGGCAAGAAGTGCATCTCCAACGCTACTCTGGTGTATCATCAGAGGACCCACACCGGCGAGAAGCCCTACCAGTGCAGCGAGTGCCCCAAGCGGTTCAGCGTGTACCAGCTGTTGCAGATTCATCTTCGTACACACACGGGCGAACGTCCATTCAAATGCACGCATTGCCCGAAAGCGTTCAAACACAAAGCCGCTCTCAACAGGCACGATCGGGTTCACACAGGAGCAAAACCTTATACCTGCCAGCACTGTGGCAAGGCTTTCTCGCAATCAAACTCCATGAAAATGCATGTCAAGACGGTACACCTCAAAATGCCCGCGCCCTACCGGCACAGGCGGAACAAAAACGAATAA
Protein Sequence
MEKLLACRVCLITDAKLYDMYKYSLVQAYEILTGMQITADGLPVHMCSMCATLLNKSALFKAKCETAQQIFKYALTQQDTLPTTYIRTIDRNLHALTLPFTVTTTFQATDDSTDIKEEDIDTDFIDNIDSLDNIEVKYESDEEPLAKKVKKKRKKKIQDKVADEKENDDFKFDVDTDKVMDDVNVDGLNDIEIVVLSKEQQINEVVLRKSSFNYLNSFYKCDKCFKGFITDSTFKNHMARHAVVSGAHVCEVCQTRWASARALRAHVVTSHERKYVCRKCDHVSKSSHRAKEHSKWHLGFTYVCKICGASFTKSTSHLTHIRLQHPSDNCCELCGDSFIGEYGLAMHRKKAHRDEDGKVKSESLCVLCGVQFRSLDALNRHISAAEDNTCNPELRPCLSCGEGFVSEESLKDHLKVHIKDDNVKCEQCNRTFAHEKSYAIHYQRVHLRVKAGGRREMCTDRVVCEICGKKCISNATLVYHQRTHTGEKPYQCSECPKRFSVYQLLQIHLRTHTGERPFKCTHCPKAFKHKAALNRHDRVHTGAKPYTCQHCGKAFSQSNSMKMHVKTVHLKMPAPYRHRRNKNE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01136061;
90% Identity
iTF_01136061;
80% Identity
-