Basic Information

Gene Symbol
-
Assembly
GCA_949127965.1
Location
OX421858.1:4471515-4480326[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.00013 0.0083 17.2 3.5 1 23 174 197 174 197 0.97
2 12 0.38 25 6.2 0.1 3 23 206 226 205 226 0.95
3 12 0.016 1 10.6 4.5 2 23 233 254 232 254 0.97
4 12 7.1e-05 0.0046 18.0 1.3 1 23 260 282 260 282 0.96
5 12 2.5e-05 0.0016 19.4 0.9 1 23 291 313 291 313 0.96
6 12 0.00089 0.058 14.5 0.1 2 23 320 341 319 341 0.94
7 12 0.00013 0.0085 17.1 6.4 1 23 347 369 347 369 0.96
8 12 4.5e-09 2.9e-07 31.2 0.6 1 23 375 397 375 397 0.98
9 12 5.1e-06 0.00033 21.6 0.3 1 23 403 425 403 425 0.98
10 12 0.0026 0.17 13.0 0.3 3 23 433 452 431 452 0.94
11 12 0.0013 0.084 14.0 0.2 1 23 458 480 458 480 0.95
12 12 1.3e-05 0.00083 20.3 1.3 1 23 486 508 486 508 0.98

Sequence Information

Coding Sequence
ATGGCCAACACTTCCTTTGATTGTGAGAAAATTTCGCAACATATAAGGATGGAAGATGTACAAAGAATGTGTCGTGTGTGTCTCGCTACGGACAGCAAAGAGCTGGTGCCTCTGATGCCCTTGGAAGACGATGGTTTGTCGGAAATGTTCACTTCATTAACGGCGATACATGAATTGCAAGACAACTTATTTCCAGCTCAACTGTGTGAACTGTGTCGAGCTGAAGTAGTCCATTGTTTCCAGTTCAGAGCCAAATGTATCAAATCTGATGACATCATTAAAACAGTACTGAAAAGAGGACTTATTGTCAAAGATGAACAAGTTGATTTTCAGGGtgTTTGGTCATTCTTTGTTTTAGTTACAGATATTCAGTATTTAGAAGATCTAGACTACAGTGATGATGACACTCTTTGCATGGTGCAGGATATGGAAATCATAAAAGGGAAAAAAGCGGAAGTATCagATTCAAAATCGCTAAAAGAACAAGTCGTCTCTGAGAAAAAATCTCAAAATCGCAACTACTACTGCACATTATGTAACAAGaaatttaaaaaagtgaaaGCATTAAGGACTCACATGAAGCTGAAGCACGAGAAAGCAGACGACCCGAACGCTTGTAGCCAGTGTAAAGAGGTTCTCGCGTCGGAGCACGACCTGGCGCTGCATGCCGCCGTGCACGCCAAGGGCCCGGTGTGGCAGTGCCTCAAGTGCCAGAAGGAGTTTCATTCGCGCACAGTGTTCCGGCGGCACGTGCGGCGGCACATGTCGCGCAAGCGGCACGCGTGCGAGCGCTGCGGCAAGGGCTTCGCGGAGCGGCACGCGCTGCGGCGCCACGCGCGCGTGCACTCCGGCCTGCCCACGCCGCGGAACCACGCCTGCCATCTCTGCGACAAGCGGTATAGTGACGCAAGCCTGTTGGCGGCGCACCTGGCGCGGCACAGCGGCGCGCGGCCGTGCGCGTGCGGCACGTGCGGCAAGGCGTTCCCCAGCGCGCGGCTGCTCGCCTCGCACGCGCTCGTGCACTCCGACCACAAGCCGCACGCCTGCCGCTACTGCGAGCGCAGGTTCCGTCACGAGTCGACGCTGCGCACGCACCTGCGCACGCACACGGGCGAGAAGCCGTACATCTGCTCCGTCTGCGGGAAGACCTTCATACAGAACTCCAACCTCACGCTGCACATGCGCACGCACACAGGCGAGCGGCCGTACGCGTGCGCGGAGTGCGGGCGCCGCTTCACGTCGGGCTCGTCGCTGAAGAGCCACGCGCGCACGCACACCGGGGAGAAGCCCTACGGCTGCGAGCTCTGCGGCAAGCGGTTCGCGCGGCTGGACCTGCGCGCGCACCTGCGCACGCACTCGGGCGAGCGCCCGCACGCCTGCTCCGCCTGCCCCAAGGCCTTCGCCAGCGCCGCGCGCCTGCGGGACCACACGCGCGTGCACACCGGTGAAAAACCTTATGAATGTGCGATGTGTCCACAAAAATATCCCACGAAGTCTCACCTCGCGAAGCATCTCAAGAGCCACGACACGAAGCGGAAAGAACGGAAGAACGTCGAAACCAGAAGTTTGGTTATACTACAACACTTAGACGAGAACACGCCCTTAGTATACACCACGACGGACCACGACGAGGTGGTCATGGAACTAGAAACATTAGACGAAGATATCCACAAAGACATGACAGTCGACATCGGAGAACAAGTGCCACTAGAAGTGACTGGAGAATTAGTGTTACAAGAAAATGGTGAAGTCAAAACCGAACTCGTGATGGTGGACGGTCAGAACACTGCCCAAAACATCTGCTTAACGAGCGACGGAGTAAACTTTTTGACCAATGATATGAGCTATGGGAATAATGTGAATTTAGTAACAGTTAATGAGGGAGAAGTCAGTATTGCGACGGCCAGCGCCGCGCTCGAGCGCAGCGTGAAGCTGTACCAGCTGGACCAGAGCCTGGTGCAGATACACAGCGCGGGCGGCCAAGTCACTATAAGCCAAATCACTAGTAAAATGACTGCTAATTTTTAA
Protein Sequence
MANTSFDCEKISQHIRMEDVQRMCRVCLATDSKELVPLMPLEDDGLSEMFTSLTAIHELQDNLFPAQLCELCRAEVVHCFQFRAKCIKSDDIIKTVLKRGLIVKDEQVDFQGVWSFFVLVTDIQYLEDLDYSDDDTLCMVQDMEIIKGKKAEVSDSKSLKEQVVSEKKSQNRNYYCTLCNKKFKKVKALRTHMKLKHEKADDPNACSQCKEVLASEHDLALHAAVHAKGPVWQCLKCQKEFHSRTVFRRHVRRHMSRKRHACERCGKGFAERHALRRHARVHSGLPTPRNHACHLCDKRYSDASLLAAHLARHSGARPCACGTCGKAFPSARLLASHALVHSDHKPHACRYCERRFRHESTLRTHLRTHTGEKPYICSVCGKTFIQNSNLTLHMRTHTGERPYACAECGRRFTSGSSLKSHARTHTGEKPYGCELCGKRFARLDLRAHLRTHSGERPHACSACPKAFASAARLRDHTRVHTGEKPYECAMCPQKYPTKSHLAKHLKSHDTKRKERKNVETRSLVILQHLDENTPLVYTTTDHDEVVMELETLDEDIHKDMTVDIGEQVPLEVTGELVLQENGEVKTELVMVDGQNTAQNICLTSDGVNFLTNDMSYGNNVNLVTVNEGEVSIATASAALERSVKLYQLDQSLVQIHSAGGQVTISQITSKMTANF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00155525;
90% Identity
iTF_01136010;
80% Identity
-