Basic Information

Gene Symbol
-
Assembly
GCA_012654025.1
Location
CM022882.1:1588668-1597682[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.00012 0.011 16.3 6.0 1 23 670 692 670 692 0.97
2 12 0.0033 0.31 11.8 4.4 1 23 707 729 707 729 0.98
3 12 0.0055 0.51 11.1 4.8 1 23 736 759 736 759 0.91
4 12 0.00044 0.041 14.5 2.3 1 23 841 864 841 864 0.96
5 12 0.0051 0.47 11.2 0.5 3 23 890 911 888 911 0.95
6 12 2.7e-05 0.0025 18.4 2.6 1 23 940 963 940 963 0.96
7 12 0.00093 0.087 13.5 0.3 3 23 1018 1039 1017 1039 0.97
8 12 0.0043 0.4 11.4 4.5 1 23 1132 1155 1132 1155 0.97
9 12 2.4e-05 0.0023 18.5 3.1 1 21 1169 1189 1169 1192 0.95
10 12 0.019 1.8 9.4 3.7 1 23 1294 1316 1294 1316 0.97
11 12 1.8e-05 0.0017 18.9 2.0 1 23 1324 1347 1324 1347 0.97
12 12 0.072 6.7 7.6 0.3 3 23 1363 1383 1362 1383 0.97

Sequence Information

Coding Sequence
ATGTATTGCCTTTTAGATGTATGGGGAAAGAATATCTGCTACGTAGGACTGACATATCTGTACGAGTATTCTAGAACAATGATGGTCTTACTGAaaaatgttattaaaatttCCAATCTAAGAAAGGAGACTCAttctaaattaaatatcaaaattgacgAACCTATTGAAACAATTCaatcaaaagaagaagatagagcTGAAGATAAAGTTCAGATAGATAATGAAATATCAGAAAACACTTCTAGTAGCACacttgaaaacaaaattgagaaaattgttATACCTATCAATGAAAAAGAAGACATCTTTAATAAATCTGACAGTGAAGTGAGGAATAGTGATGGAATGGTTATTGAACATAAAAAGGTTGAATTTGAAGGTAGTGATGAATTACAAAAGAAGCCCGATCATGTTGAAAAAATACGTGTAGATAATGAACAAAGTATTAGTgataaacaaattattgaaaaggACGATACTGATGAAAAATTTGagtataaaaatgtaaatgaagagTTGAATAGTAATGAAACTGGTTGTGTTGCTGGCGTAGATAGTGGTATTGCTAATGCAAGTGTTGCCGATGGTGTTGCCCGTGTAGATGGTAATAGTATACTTGCAAAATATATGAATGAATCTAAACAAAAACATGTTATGTTAGGTGGTATAAGTTTAgaattacaaagaaatatacaattacTAGAAAGGAACAATGTTCAATTGTTAGACAAACCAACTATGTTAAACAAAGACGTTACAATATATCCAAATATTAAATCCAAATCAAAAGATACGTTACATACTGGAATAGGAGATGTAGGTCATTCAACAACcggttttgaaaatattggaaataattTTCCACATAGAATACAACAACAACCTATACATAATCCAAATTTAAGTTATAGAATTCCAATTCAAATGGTACCGTCACAGTATGTACAATATCAACCAGTATTAGCATCTAGAATGCCAGGACAATTACATAATCAAGGTTTTATTCAAATACAAAGTCGACTTCCAGGAGCGTTTCATAATATGCCAGATAGATTTAATCCTCCTGCATTAATACCATTCCAAAATCAAATTCCAACTGGGTATGTTCAAATACAAAGACCAATgaattcaaatcaaaatatgTCACCAGCAATAGGAGGAGGGGGTcctataaaaattcaaaatagaatgatacaaatgaaagttcaaaataGAATTCAGCACATGACACCTATATTACCAAAAAGTTCAATTCAATTACATCAATATCCAACATTTTATTCGACTCCTAATAGATTTTCGAGTATAGTTCCAAATATTAGGGAAAGATCTTTATCTGGGCCAATTTCTGGAAACGTCTCATCTGAAAATCTACAATCTTTTACTCCATCTgataattttgaaagatatcCTCCAAGAAGTTATTCCTCTGAACCACAAATTGAAACATCTGTAGCTAATATTCATTCTATTGGAGATCCTTATCAACAAGATATGTACCGAACTACATATCAAACAGATATGTATGGAAGAgatcaaaatataaatagtgGACTGTATTATACTACAGGAAATGAAGGATATTCAACAGAAAGATCACGTGATATGTATCAAACAAATTCACCTAACATTCAACATACTCCTGATAACATAGATAAAGAGGCAAATGAATTAAAGAAGCTACAACAAGTAAACGAGAAAGTTAAAacgaatgaagaaaatattaaaaactcaAATGAGACACGTACTGAAACCCGTAATGATAATGAAGATGGAGGTGAATTTGTTGATTTCGAAGAAGCTGCTCATTTAAATGTTTATCCTGATGCAAATGAGGgagaaaattttgatgaaaatattagtaTTGAACATTTCTTACAAGTAGACTACAATGATTCTGTtaataacaatgaaaatataGACGAAACAACTCCATCCGGCGAACAAAGTGTACAACCTGAACAATCAAATCAACTTCAAATGAGTCGACCAAAaacaattatatttaaatgtaaatattgtaagAAGAAATTCTTCCATAAAAAAGAATTGGAAAAACATTTGATTGGACATTCAACTTATACCCGAGTTCGAAATGATGGCAAAAAGAGAGATTTTCCATGTTCACTTTGTGATTGTTCATAtttaagaaaaacacatttagaAAGACATATGTTATCTCATATGAAAAAACAAGATCAATATAAATGTGAACAATGTAATTATTTCTTTGTTCATAGAAGACATTTAGAAATACATAATTTACAAAGTCATTCTACTACTAAAATTGAATCTGAGCTTCAAAATGAGagtgaagaagaagatgatgacaTCGATGAAAATGATGGTATTTCAAATGACCCACAAGTTGAAGTGGTCTCAGTTGATCCGAATGCACCAGATTTCACAAATGAACATCAACCAGAGGTATCTATTACTACGAAAAGCAAAGATGAAATCATtgattcaaatcaaaaatcttcttcTATGCATAAATATTCAAATGTTAAAAGATCATTCTTTTGTCCACACTGTGGTCgagcttttttgaaaaatcaatatttaagaGCCCATATACGTAATTTTCATGATGgaaatttttctgaaaatgctGCTTCCCAAATGTTTGGCGACGCACCTTATTTACAAAGGAAAACACTTTTTTGTCCAATCTGTGGTCAaggttttataaaaataaagtatttccGATCTCATTGGAATAAATTTCATGAGGAAGAAACACGTCGTACTGATGGTAAAAAAGCGAATGTTGAACCATTAAATGAACCTCCAGAACCATTGGTGAAAAAACCATTTGTATGTCATATATGTAATAATGGTTTTTATCAtccacaaaatttgaaaagacaTATTCGAGATGTACATTATAAAATAAGACCGGGAAAGAGAAGTGAGCGTTCTGGTGTAGGAGATAGAACGATACGTTCAGGCGATGAAGAAGATATGGATTTTGAATTAGAAGAAGAAGCGGCTGAAGTAGGTAttgttaatattgaaaaatcaattgCAGAAGGAACAGGTTCATTTTGCCCAATATGTaataaagaatttttgtatgaatataatgttAAAAGACATATTCGAAGTGCTCATTCTGAATACGCCTATatgattccttttaaaagaaaatcaaaatcgaATCCATCTACAGAGATtggagaagaagatgaagatgaGACGGCTGCAGAAGAAGAAACTGAAGATATTGAACAAGAACACGATCAATCAATAACATTTTCACAATTAAGTTCTTCGAATATTAACGAATCTGAATTAATGGGATGGAATATGGATGACGATGGTAGTGAAGATACACCAGGAAACAAAAAAAGTGATCAAACATTTTTAGGATCTTCTGAAGATCGACCATTCAAATGTACACTTTgtgataaaagatttttcagattattatttcttaaacGTCACTTTTCAACATCCCATGGTGTATCACATCCAGATACAACAGAAACAGATTGGAGTTTTGAATGTCAATCATGTGGTAAACGATTTGCTAGAAATGATTCTTTAATACGACATATgaaatgtaaacataaaaaaatatttcgtgcAATGCGAGGAGAGAAAATTAGAAAAGCTTATGCTGGACATGTTAAAGAATTTGCTAATAAaacgaaaaacaaaattgacacTGGAGCTGATATGAGTGTAAATGTTGACATAGAAACAAATATTGAAGAACAATGTGAATCAGATGgagttgaaagaaaaatggaTGAATATGTCGAAAGTTTGGATAATCGAACAGATTTAACTCACCAGAGTATACCAGTTGAACAAATATCTTCAAATACACAATTAGAATCGTCATCTGTTGCTacaccaaaattgaaaatttatcgtTGTACATTATGTAACTCTAGTTTCtttactaaatttgaatttgtCAAACATAGAAGTTTGCACAGTAATATAAAACCAAGGAAAtacaaatgtaaatattgtagTATGAAATTTGTACAATTTGCAAATTTAAGAAAACATATAAATCAAATTCATGCTAAACATAGTAATGTAGGAGGATTTGTTGGACCTACCAAAAATTGTAGTAAATGTTCTTTTATAGCAACAAATAATATTGCGCTAAGTAATCATATGAGAGCTCATGTGAGGGAAGAAACGTCAGATGAACAGAATCACATCGTAAAGTTCTTATTAATAGAGGCAATAAAACGAATGGCAGAAAATAAAGTCAACAGAAAAGAAGGAGAACGACGGAACGACAAGGTAGAGAAATTACTAGAAAAGAAGCACCAAGACAGAACGAGAGTCCAATGTAGAGAAGGAAATGAAGTTAATAGAAAAGAAAGACCACGACAGGACGAGAGTTCAATGTAG
Protein Sequence
MYCLLDVWGKNICYVGLTYLYEYSRTMMVLLKNVIKISNLRKETHSKLNIKIDEPIETIQSKEEDRAEDKVQIDNEISENTSSSTLENKIEKIVIPINEKEDIFNKSDSEVRNSDGMVIEHKKVEFEGSDELQKKPDHVEKIRVDNEQSISDKQIIEKDDTDEKFEYKNVNEELNSNETGCVAGVDSGIANASVADGVARVDGNSILAKYMNESKQKHVMLGGISLELQRNIQLLERNNVQLLDKPTMLNKDVTIYPNIKSKSKDTLHTGIGDVGHSTTGFENIGNNFPHRIQQQPIHNPNLSYRIPIQMVPSQYVQYQPVLASRMPGQLHNQGFIQIQSRLPGAFHNMPDRFNPPALIPFQNQIPTGYVQIQRPMNSNQNMSPAIGGGGPIKIQNRMIQMKVQNRIQHMTPILPKSSIQLHQYPTFYSTPNRFSSIVPNIRERSLSGPISGNVSSENLQSFTPSDNFERYPPRSYSSEPQIETSVANIHSIGDPYQQDMYRTTYQTDMYGRDQNINSGLYYTTGNEGYSTERSRDMYQTNSPNIQHTPDNIDKEANELKKLQQVNEKVKTNEENIKNSNETRTETRNDNEDGGEFVDFEEAAHLNVYPDANEGENFDENISIEHFLQVDYNDSVNNNENIDETTPSGEQSVQPEQSNQLQMSRPKTIIFKCKYCKKKFFHKKELEKHLIGHSTYTRVRNDGKKRDFPCSLCDCSYLRKTHLERHMLSHMKKQDQYKCEQCNYFFVHRRHLEIHNLQSHSTTKIESELQNESEEEDDDIDENDGISNDPQVEVVSVDPNAPDFTNEHQPEVSITTKSKDEIIDSNQKSSSMHKYSNVKRSFFCPHCGRAFLKNQYLRAHIRNFHDGNFSENAASQMFGDAPYLQRKTLFCPICGQGFIKIKYFRSHWNKFHEEETRRTDGKKANVEPLNEPPEPLVKKPFVCHICNNGFYHPQNLKRHIRDVHYKIRPGKRSERSGVGDRTIRSGDEEDMDFELEEEAAEVGIVNIEKSIAEGTGSFCPICNKEFLYEYNVKRHIRSAHSEYAYMIPFKRKSKSNPSTEIGEEDEDETAAEEETEDIEQEHDQSITFSQLSSSNINESELMGWNMDDDGSEDTPGNKKSDQTFLGSSEDRPFKCTLCDKRFFRLLFLKRHFSTSHGVSHPDTTETDWSFECQSCGKRFARNDSLIRHMKCKHKKIFRAMRGEKIRKAYAGHVKEFANKTKNKIDTGADMSVNVDIETNIEEQCESDGVERKMDEYVESLDNRTDLTHQSIPVEQISSNTQLESSSVATPKLKIYRCTLCNSSFFTKFEFVKHRSLHSNIKPRKYKCKYCSMKFVQFANLRKHINQIHAKHSNVGGFVGPTKNCSKCSFIATNNIALSNHMRAHVREETSDEQNHIVKFLLIEAIKRMAENKVNRKEGERRNDKVEKLLEKKHQDRTRVQCREGNEVNRKERPRQDESSM

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-