Basic Information

Gene Symbol
TFAP2A
Assembly
GCA_958009045.1
Location
OY253753.1:7013412-7034830[-]

Transcription Factor Domain

TF Family
AP-2
Domain
TF_AP-2 domain
PFAM
PF03299
TF Group
Basic Domians group
Description
Activator protein-2 (AP-2) transcription factors constitute a family of closely related and evolutionarily conserved proteins that bind to the DNA consensus sequence GCCNNNGGC and stimulate target gene transcription [PMID: 2010091, PMID: 1998122]. Four different isoforms of AP-2 have been identified in mammals, termed AP-2 alpha, beta, gamma and delta. Each family member shares a common structure, possessing a proline/glutamine-rich domain in the N-terminal region, which is responsible for transcriptional activation [PMID: 2010091], and a helix-span-helix domain in the C-terminal region, which mediates dimerisation and site-specific DNA binding [PMID: 199812]. http://www.ebi.ac.uk/interpro/entry/IPR013854
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 3.6e-85 7.4e-81 270.9 0.0 1 196 22 215 22 216 0.98

Sequence Information

Coding Sequence
ATGAAACAGTCGGACAGGGGTGACAAGTCGATGTTGTCGGGTAACGCGCAGCCCTCGGACGTTTTTTGTTCGGTACCGGGTAGATTGTCGCTGTTGAGCAGCACGAGCAAGTACAAAGTGACGGTTGCCGAGGTGCAGAGACGATTATCACCGCCGGAATGCCTAAACGCAAGTTTACTCGGTGGTGTATTACGGAGGGCAAAGTCAAAAAATGGCGGAAGACTGCTGAGGGAAAAACTCGAGAAAATTGGCCTCAATTTGCCCGCTGGAAGAAGGAAGGCTGCCAACGTAACGCTCTTAACGTCCTTGGTGGAAGGCGAGGCTATTCACCTGGCGAGAGACTTTGGATACGTCTGCGAGACGGAGTTCCCGGCGAAGCAAGTAGCCGAATACCTGAGTCGGCAGCACTGCGAACCTCAGGATTCCTACAGGAGAAAAGAACTTCTTCATGCGACCAAaCAAATCACCAAAGAGCTGATGGATCTTTTGAACCAGGACCGATCGCCATTGTGCAACACCCGACCACCTCACATTTTAGACCAGAGTATACAAAGACACTTAACGAATTTCTCATTAATATCACACGGATTCGGTAGTCCGGCGATCGTTGCAGCGCTCACAGCGATACAGAAGTTCCTAAGCGAGTCGTTGAATCATCTTGAGAAGATGTATCCGGGCAATGGTAGCGGTGTGACGAGCAGTCAACAGTCGAATTTGGACGGTAACAAGAACAAGGACGGTTCGTTGATGAACGATATGAAGAAGTGA
Protein Sequence
MKQSDRGDKSMLSGNAQPSDVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRLLREKLEKIGLNLPAGRRKAANVTLLTSLVEGEAIHLARDFGYVCETEFPAKQVAEYLSRQHCEPQDSYRRKELLHATKQITKELMDLLNQDRSPLCNTRPPHILDQSIQRHLTNFSLISHGFGSPAIVAALTAIQKFLSESLNHLEKMYPGNGSGVTSSQQSNLDGNKNKDGSLMNDMKK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00689857;
90% Identity
iTF_00459428; iTF_00057608; iTF_00720937; iTF_01001774; iTF_00397743; iTF_00059130; iTF_00396954; iTF_01207034; iTF_01560123; iTF_01306077; iTF_01364317; iTF_00628798; iTF_00058367; iTF_00413983; iTF_00840735; iTF_01055655; iTF_01057320; iTF_01056476; iTF_00439149; iTF_00215393; iTF_00359905; iTF_00689857; iTF_01190017; iTF_01392449; iTF_00225602; iTF_00962882; iTF_00217443; iTF_00219491; iTF_00863651; iTF_00762244; iTF_01103236; iTF_00393285; iTF_00773477; iTF_01513157; iTF_01469350; iTF_00086791; iTF_00220167; iTF_00302727; iTF_01508551; iTF_00182984; iTF_00384968; iTF_01489096; iTF_01273481; iTF_01468521; iTF_00738026; iTF_00860074; iTF_00861578; iTF_00968490; iTF_00168076; iTF_00223564; iTF_00262348; iTF_00713388; iTF_00864332; iTF_01218764; iTF_00265357; iTF_00905101; iTF_01390765; iTF_01393965; iTF_00218798; iTF_00286030; iTF_00829166; iTF_00860814; iTF_00084975; iTF_00216079; iTF_00460175; iTF_00862255; iTF_01233327; iTF_00728976; iTF_01419345; iTF_00222226; iTF_00309202; iTF_00738770; iTF_01378898; iTF_01389874; iTF_01511890; iTF_00126387; iTF_01464723; iTF_00079508; iTF_00867860; iTF_01389108; iTF_01100277; iTF_01391637; iTF_01417397; iTF_01537525; iTF_00229046; iTF_01419990; iTF_00668119; iTF_00981975; iTF_01393175; iTF_00862968; iTF_00865016; iTF_00088473; iTF_00969273; iTF_01101017; iTF_01523737; iTF_00231002; iTF_00216763; iTF_00218107; iTF_00266139; iTF_00305947; iTF_00798267; iTF_01035899; iTF_01493275; iTF_01513851; iTF_00010780; iTF_00227644; iTF_00232924; iTF_00982652; iTF_01539292; iTF_00084221; iTF_01101757; iTF_01298845; iTF_01514525; iTF_00228350; iTF_01488222; iTF_00085855; iTF_00866399; iTF_01379711; iTF_01381023; iTF_00222880; iTF_00884736; iTF_01267232; iTF_01113123; iTF_01109803; iTF_01112276; iTF_01110621; iTF_01111455; iTF_01216492; iTF_01035138; iTF_00143573; iTF_01274175;
80% Identity
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