Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00091 0.13 14.0 4.6 1 23 92 114 92 114 0.98

2 6 0.052 7.4 8.5 3.9 1 22 123 144 123 147 0.91

3 6 0.00029 0.041 15.6 3.0 2 23 173 194 172 194 0.97

4 6 9.9e-06 0.0014 20.2 1.4 1 23 203 225 203 225 0.99

5 6 0.0071 0.99 11.2 2.8 1 23 234 256 234 256 0.98

6 6 0.0021 0.3 12.9 1.9 1 21 265 285 265 286 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00091	0.13	14.0	4.6	1	23	92	114	92	114	0.98
2	6	0.052	7.4	8.5	3.9	1	22	123	144	123	147	0.91
3	6	0.00029	0.041	15.6	3.0	2	23	173	194	172	194	0.97
4	6	9.9e-06	0.0014	20.2	1.4	1	23	203	225	203	225	0.99
5	6	0.0071	0.99	11.2	2.8	1	23	234	256	234	256	0.98
6	6	0.0021	0.3	12.9	1.9	1	21	265	285	265	286	0.95

Coding Sequence: ATGGATTTAGGACATAGGAATATGATTGACAATTCTAATGATGCAAGAAGTTTAATACTTAATGAAGAGgcaaatgttttaaagaaagaatTGACTATGTTAAGAAATGAAACAGATGTTGGACAAACAGATGTGGTAGTAACGGAAAGAAACaactttttttctcattttttggACGCTTCTATTGATTCCAAATGCGACTTTGAAGAAATTAAGGAAGAAAACGCTGAAACTGAAAGCGACAAAAATATCGACAAAGatgaaatcaatatttttaaatgtaacgAGTGCTCTTACGTAACTAAATATAAACAGTGCCTAACACGACACAGAATAATTCATAAAAGTGCAGATGAAGCGACATTCTACTATTGTTATCTTTGTAATTTTAAGACAAAACATAGGGTGTCGCTGAAAACTCACTTGGCCTCAAATCGACATAAAAGTCTCGAGAGTGTTACTACCCCTGAGGACAGTGAACTGCAAGACAGGTGTATCATTCAGGATGAAAAACTCCAATGCGAATTATGCCCTTACATGACAAGAAGTAAACACAATTATACTAAACATTTGCTTAAGCATAAAAATCCCCAGGACTGTACCATGTACAAGTGCGACGTATGTTCGTACGAGACCAAACGAAAAGGCAATATGACGAACCACATGTTGACGCATAAAAATATAGACGACGTGAAATGTTTTAAGTGCCAGTTGTGTGATTTTAAAACGAAGTTCCAGAGTACCATGTCCAGCCACGTGTTGACGCACAAAGATCCAAACGAACTGAAGATGTTTAAGTGCCCCAAATGTTCGTATCaggcaaaatataaaaaaagtcttACAAGACATCTGTCAAAAACTCGATGTTCAAATCAAAAAAGAGAGACGACAAATTTAATGCAACAAAATCATCTCAGTGAAGTGGGAAAAATGGAATGGTTATGA
Protein Sequence: MDLGHRNMIDNSNDARSLILNEEANVLKKELTMLRNETDVGQTDVVVTERNNFFSHFLDASIDSKCDFEEIKEENAETESDKNIDKDEINIFKCNECSYVTKYKQCLTRHRIIHKSADEATFYYCYLCNFKTKHRVSLKTHLASNRHKSLESVTTPEDSELQDRCIIQDEKLQCELCPYMTRSKHNYTKHLLKHKNPQDCTMYKCDVCSYETKRKGNMTNHMLTHKNIDDVKCFKCQLCDFKTKFQSTMSSHVLTHKDPNELKMFKCPKCSYQAKYKKSLTRHLSKTRCSNQKRETTNLMQQNHLSEVGKMEWL

Sequence clustering based on sequence similarity using MMseqs2