Basic Information

Gene Symbol
-
Assembly
GCA_951805005.1
Location
OX638141.1:66606203-66610353[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 4.2e-05 0.0068 18.6 0.7 1 23 12 34 12 34 0.97
2 10 2.9e-06 0.00047 22.2 1.5 1 23 40 62 40 62 0.97
3 10 1.3e-05 0.0022 20.2 1.8 1 23 68 90 68 90 0.97
4 10 3e-05 0.0049 19.0 1.3 3 23 98 119 96 119 0.96
5 10 0.03 4.9 9.6 5.7 1 23 125 147 125 147 0.96
6 10 0.0061 0.99 11.8 0.1 6 19 159 172 156 176 0.92
7 10 1.8 3e+02 4.0 0.1 12 23 193 204 185 204 0.80
8 10 7.8e-05 0.013 17.7 1.1 1 23 210 232 210 232 0.97
9 10 0.051 8.3 8.9 0.1 5 23 242 260 241 260 0.91
10 10 9.7 1.6e+03 1.7 0.1 3 11 268 276 266 280 0.89

Sequence Information

Coding Sequence
ATGCATGAGCCGACCCACACTGGAAAACCAACTCATGTTTGTGACTTGTGCGGTAAGGGATTTTATTACAAGGTGGTTTTGAAGGAGCACATGCTGAGCCATACGAAGGAAAAGCCGTTTAAATGTGATAAATGTGACAAGGCATTCACTATGAAATCAAAACTCCGTATTCATGAGAATCTCCACACTGGGCAGCGGAAGTTTATGTGCAACATTTGTAGTAAGAATTTCTTCTCCAGCCGCTCTCTCAAAGAACACATGACAGTTCACATTAAAGGGAGACTTATTGATTGTAATATGTGCAAAAAGCAGTACAGGAGCAAATCTGTTCTCCGGTGGCACCAAAGAAAGGAACACAAAGCAAACCATCCACACAAGTGCGAGAAATGCTGCTCGAGTTTTCGTACGGAATCATTATTAAAGAAACATATTGTGAATCATGAGAAAGAGGAGAAAAGCCATTTGAATGTAAGATGTGGCAGACCTTTTGCAAGGAAGTCGAGCTTAAAATTGCACGAGCCCATCCATACAGGAAAAAGACCCCACAGTTATGAATTTTGCAGTAGCAGCTACCTTTATAAAGCATCCCTGAAGGAGCATATGATCAGGCATACAAATGCAAAACCATTTAAATGCTCTACATGTGAGAAGGTGTTCGGGTTCAAGGAATATCTACGCGTACACGAATTGAGTCACTCCAGACTGCGAAACTACAAGTTCGATCTTTGTGACAAAGCCTTCAATAGCCCAGGCAGTCTTGGAGAACACAAGCATGCTCACGTGACTGACAGACGTTTTGGTTGTAAAATATGTGAGATGCAGTTCAGTGTAGGAAGTCTCGCCGGTTTCATATGA
Protein Sequence
MHEPTHTGKPTHVCDLCGKGFYYKVVLKEHMLSHTKEKPFKCDKCDKAFTMKSKLRIHENLHTGQRKFMCNICSKNFFSSRSLKEHMTVHIKGRLIDCNMCKKQYRSKSVLRWHQRKEHKANHPHKCEKCCSSFRTESLLKKHIVNHEKEEKSHLNVRCGRPFARKSSLKLHEPIHTGKRPHSYEFCSSSYLYKASLKEHMIRHTNAKPFKCSTCEKVFGFKEYLRVHELSHSRLRNYKFDLCDKAFNSPGSLGEHKHAHVTDRRFGCKICEMQFSVGSLAGFI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-