Basic Information

Gene Symbol
-
Assembly
GCA_951805005.1
Location
OX638140.1:44629388-44635844[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 3.2e-06 0.00052 22.1 0.4 1 23 180 202 180 202 0.97
2 12 0.01 1.7 11.1 2.7 1 23 208 230 208 230 0.96
3 12 8.6e-05 0.014 17.6 3.0 1 23 236 258 236 258 0.98
4 12 0.0022 0.35 13.2 1.3 3 23 272 292 270 292 0.95
5 12 5.2e-05 0.0084 18.3 0.4 2 23 299 320 298 320 0.97
6 12 8.5e-06 0.0014 20.8 5.6 1 23 326 348 326 348 0.97
7 12 3.8e-06 0.00062 21.9 0.1 1 23 354 376 354 376 0.96
8 12 5.3e-06 0.00087 21.4 0.1 1 23 382 404 382 404 0.98
9 12 3.3e-07 5.3e-05 25.2 2.0 1 23 410 432 410 432 0.98
10 12 1.2e-06 0.0002 23.4 3.8 1 23 438 460 438 460 0.98
11 12 6.9e-05 0.011 17.9 0.9 1 23 466 488 466 488 0.97
12 12 4.2e-07 6.8e-05 24.9 0.2 1 23 494 516 494 516 0.98

Sequence Information

Coding Sequence
atggacatgagCGTCTACCTGACGGCGCCCCTGCAGCTCGACAAGATATGCAGAGCGTGCCTGACGGAGAAGGGCGACATGCGGCCCCTCTTCGGGGCCTGCCTCGACGAGATGCTCCTCTCCTTCGCCACCATACAGGTGCAGGAAGGTGACGGCCTACCGAATCTCATATGCGTACAATGCGTCCTGCAGTGCAGCAGGGCCTACACTTTCAAACAGCAATGCGAGAAGTCCGAGAACATACTTCGGAGCTACATAAGCCCCGAATTTCAGGAACAATTGGCGCAGTCATTGGATCATCATACCGTGAAGTTGGAGGAGCAGCTggattttgcagaaaatatcgCCACCGTCGTCATCGAAGAGGACCTCCCCAGTGATTTCGTAAATGTCAATTACACCGAAGAGTGCGGATTGgagGTTAAAAATGAGCTGATGTACAACATGGAGGGCATGGTTGACTCCAATGATGATGCCTTGAATAAAGATGACCTGGACGACATTGGCGAAGGCAAGCACAGCCTGTTCAAACAGAAGTACCCCTGCACGAAGTGCGAAAAGTCGTTCAGCTTGAAGGTAGACCTGAAGGTGCACATGATGGGCCACCCCAAGGACCTGGATCACGTGTGCAACGTCTGCCACAAGGGCTTCTCGGAGGCACGCATACTGAAGAGACACTCGAAGATTCACCTGGAGAAGAAGCCGCACCAGTGCGACCAGTGCGAAATGTCGTTCGCCGAGAGCTCCAACCTGAGCAAGCACAAGAAGAAGCACACCGGTGAGCTGAGGAATATCAAGGGCAAGCCACACCTCTGCTCGGCGTGCGGCAGGGCCTTCAAGTGGGCCTCCAGCCTGTCGAAGCACATGAAGTACCACACGGGGCACAAGCTGCTCACTTGTGAGTACTGCAACAAGCAATACGTCGAGgcAAGGAGTTTGCGGATCCACATTCGGTCACATACCGGCGAACGTCCGCATGTGTGTGAGATTTGCCACAAGAGCTTCACGCAGGTGTGCAATCTCGAGAAACATCTCCGCGTGCACACAGGCGAGAAACCTTTCCTCTGTCCAATTTGCGGTAAAGGGTTTACTCAGTCAGGTTACGTGGGCATCCACATGCGCACCCACACGGGGGAGAGGCCATACGTGTGCACGACATGCGGAAAAGCGTTTGCAGGATCCAATACCCTGGCCATTCACCAAAGGATCCACACGGGCGAAAAACCTTACTCGTGCAATATATGCGGCAAATCATTCAGCAGGCACGAGACGCTCGTCATACACACCAGGTCACACACAGGTGTCAAGCCGCACGTCTGCTCGCTCTGCAATAAGGCCTTCACATCGAGCAGCCACCTCTCGGGCCACATGAGGACTCACACAGGCGAAAAGCCGCATGAGTGCAATGTATGCATGAAACGCTTTGCAGGGTCCAGCAGCTTGAAGGTTCACATGCGCGGCCACTCCGGGGATAAGCCGTTCGTGTGTAAGGTGTGTGGTAAACTATTCGCTCAGGCAAGCACCCTGCAGCAACACATGGCAACGCACTCCGTGCTAGAGATCAGCAAGATGCCCAAGGTGGAGACCGTGCAAATAGCCGACTTGCTGACCGGGGAGACTGTGCACACTGTTCAGGTGCAGACGTTGAGTTAG
Protein Sequence
MDMSVYLTAPLQLDKICRACLTEKGDMRPLFGACLDEMLLSFATIQVQEGDGLPNLICVQCVLQCSRAYTFKQQCEKSENILRSYISPEFQEQLAQSLDHHTVKLEEQLDFAENIATVVIEEDLPSDFVNVNYTEECGLEVKNELMYNMEGMVDSNDDALNKDDLDDIGEGKHSLFKQKYPCTKCEKSFSLKVDLKVHMMGHPKDLDHVCNVCHKGFSEARILKRHSKIHLEKKPHQCDQCEMSFAESSNLSKHKKKHTGELRNIKGKPHLCSACGRAFKWASSLSKHMKYHTGHKLLTCEYCNKQYVEARSLRIHIRSHTGERPHVCEICHKSFTQVCNLEKHLRVHTGEKPFLCPICGKGFTQSGYVGIHMRTHTGERPYVCTTCGKAFAGSNTLAIHQRIHTGEKPYSCNICGKSFSRHETLVIHTRSHTGVKPHVCSLCNKAFTSSSHLSGHMRTHTGEKPHECNVCMKRFAGSSSLKVHMRGHSGDKPFVCKVCGKLFAQASTLQQHMATHSVLEISKMPKVETVQIADLLTGETVHTVQVQTLS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

90% Identity
-
80% Identity
-