Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.0014 0.071 13.4 1.3 2 23 81 102 80 102 0.96

2 6 2.1 1e+02 3.4 3.8 1 22 135 155 135 157 0.70

3 6 0.14 7 7.1 1.3 1 23 162 185 162 185 0.93

4 6 0.001 0.051 13.8 1.2 2 23 202 224 201 224 0.96

5 6 0.00047 0.023 14.9 0.3 2 23 229 251 229 251 0.97

6 6 0.0012 0.059 13.6 5.1 5 22 261 278 258 281 0.88

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.0014	0.071	13.4	1.3	2	23	81	102	80	102	0.96
2	6	2.1	1e+02	3.4	3.8	1	22	135	155	135	157	0.70
3	6	0.14	7	7.1	1.3	1	23	162	185	162	185	0.93
4	6	0.001	0.051	13.8	1.2	2	23	202	224	201	224	0.96
5	6	0.00047	0.023	14.9	0.3	2	23	229	251	229	251	0.97
6	6	0.0012	0.059	13.6	5.1	5	22	261	278	258	281	0.88

Coding Sequence: atggtgctgCCTTCAGAAATGGTAATAAAGCAGGAAAAAGAGGACTTGGAGCATAACCCTGCAGATTATTTGAGCCCAGACTTCGAAGTTACAGTAAAAGTTGAAGTGGAAAGCTCTCAAATCAGAGAATATGAAGTTAAAACTGAATTTATAGGTGATGAAAACACTGAGGTTTTTGAGTCTGAGGAGGTAGAATTCGATGGCGTTGAGTATGAAGATTTGATACAGTACACACGGGTTACGTGTGCAATTTGTAATGAGGAGTTTTGTGAAAGGTATTCACTACTGCGGCACAATTTGAAACATTTAAGACTCCTAATTGAACCATTGGGAACAATAATTCAGAAAGATAATAATAACGTCCCAATTAAAAGAAAGAAGTCACTGGTAACGAAAGAACTGCATGAGTGTAAAATATGTGGCAAAATCCAAACGTACAAAACTTGGCATTCCCACATGAAAGAGGTTCATGGTACGGAGGAATACGAGTGCAGCGTTTGCTCTGCTGTGTTCAAATGTGCGAGGTACGCACGTAAGCACATCTACAGTATACATATGAACAAGAAATTCAAAGGCAGTCGGCAAATAGAAGGAGTCGAAGTAAAATGTACCTTATGTCCTGCTATACTGAAGAGTAAATATGCATTATCAACGCACATGAGAAACTGTCACAGTGAGAAAGCTCAATGTGAAATCTGCCAGTCTGTGTTGAAAAGTAGGTCGTATTTGCTGATTCATATGAACAGAGTACATTACAACGATGGCAAAGAGCACAAATGTCACTGCGGAAAGAAGTTTCGGTCGCCGAGATATTTGAAAATACACATGAAAAATTCCAAACATGCAAGGAGATGA
Protein Sequence: MVLPSEMVIKQEKEDLEHNPADYLSPDFEVTVKVEVESSQIREYEVKTEFIGDENTEVFESEEVEFDGVEYEDLIQYTRVTCAICNEEFCERYSLLRHNLKHLRLLIEPLGTIIQKDNNNVPIKRKKSLVTKELHECKICGKIQTYKTWHSHMKEVHGTEEYECSVCSAVFKCARYARKHIYSIHMNKKFKGSRQIEGVEVKCTLCPAILKSKYALSTHMRNCHSEKAQCEICQSVLKSRSYLLIHMNRVHYNDGKEHKCHCGKKFRSPRYLKIHMKNSKHARR

Sequence clustering based on sequence similarity using MMseqs2