Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.00011 0.0056 16.8 3.7 1 23 112 134 112 134 0.99

2 5 3.3e-05 0.0016 18.5 7.8 1 23 140 162 140 162 0.98

3 5 2.4e-07 1.2e-05 25.3 2.1 1 23 168 190 168 190 0.98

4 5 0.00018 0.0089 16.2 0.0 1 23 196 218 196 218 0.96

5 5 7 3.5e+02 1.8 0.5 6 20 228 242 226 244 0.84

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.00011	0.0056	16.8	3.7	1	23	112	134	112	134	0.99
2	5	3.3e-05	0.0016	18.5	7.8	1	23	140	162	140	162	0.98
3	5	2.4e-07	1.2e-05	25.3	2.1	1	23	168	190	168	190	0.98
4	5	0.00018	0.0089	16.2	0.0	1	23	196	218	196	218	0.96
5	5	7	3.5e+02	1.8	0.5	6	20	228	242	226	244	0.84

Coding Sequence: ATGGCATTGTCCCTGCAGTCTTCGCAGAACTCGAGAGGTGTGTCTGTGAGGCCGCTATCAAGCATGCGCCAAGAGTCGCTGCCGATGCTGGCGGAGCGGCTGCTGGCGTCGCGCGCCGCCGCGCTGGTGGCGGGGCTGCCGGCCGAGCTGTACTCGGGCGCGCTGCTGGCCGCCTGGCCGCcctcgccgcccgcgccgctgctGCCGCCGCCCGAGCTGGACCGCGCCCGCAAGCGCCGCCGCACGCCCAAGCTCGAcgacgccgccgcgccgccctccCCGCCCTCCTCCGGCTCCTCGCCCGGCGCCGCCGACCCCCCCCGCGACAAGCTCTTCACCTGCAAAGTCTGCTCACGGTCCTTCGGCTACAAACACGTCCTCCAGAATCACGAGCGCACCCACACGGGGGAGAAGCCGTTCGAGTGCGGCGAGTGCCACAAGCGCTTCACGCGCGACCACCACCTCAAGACGCACCTGCGCCTGCACACGGGCGAGAAGCCGTACAGCTGCCCGCACTGCCCGCGCCACTTCGTGCAGGTCGCCAACCTGCGCCGCCACCTGCGCGTGCACACCGGCGAGCGCCCGTACGCCTGCGCGCGCTGCCCGGCGCGCTTCTCCGACTCCAACCAGCTGAAGGCGCACGCGCTGGTGCACGAGGGCGACGCGCCCTTCGCGTGCCGCTGCGGCGCGCGCTTCCGGCGGCGGCAGGCGGCGGCGCTGCACCGCTGCGCGGGCTCGGGCTGCGAGCCGGAGGCGCCGagcccgcccgccgccgccgccgactgGCGCTGGGACGAGTGGCCCGAGCAGACGGAGCCGGAGGACCTGTCGCTGCCGCGGAGGCCGGCCACCCCTGACTCGCCCACCGACCTGCGCGTGCACTCCGCGTAG
Protein Sequence: MALSLQSSQNSRGVSVRPLSSMRQESLPMLAERLLASRAAALVAGLPAELYSGALLAAWPPSPPAPLLPPPELDRARKRRRTPKLDDAAAPPSPPSSGSSPGAADPPRDKLFTCKVCSRSFGYKHVLQNHERTHTGEKPFECGECHKRFTRDHHLKTHLRLHTGEKPYSCPHCPRHFVQVANLRRHLRVHTGERPYACARCPARFSDSNQLKAHALVHEGDAPFACRCGARFRRRQAAALHRCAGSGCEPEAPSPPAAAADWRWDEWPEQTEPEDLSLPRRPATPDSPTDLRVHSA

Sequence clustering based on sequence similarity using MMseqs2