Basic Information

Gene Symbol
-
Assembly
GCA_004796505.1
Location
SSSI01002328.1:4929-10187[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 0.33 31 5.3 0.0 3 23 317 338 315 338 0.88
2 17 1e-06 9.6e-05 22.7 0.1 1 23 394 417 394 417 0.97
3 17 1.5 1.4e+02 3.2 0.1 1 23 455 477 455 477 0.90
4 17 1.1 1e+02 3.7 2.0 2 23 516 539 515 539 0.92
5 17 0.00042 0.04 14.4 4.6 1 23 542 565 542 565 0.96
6 17 0.013 1.2 9.8 2.1 2 23 572 594 571 594 0.95
7 17 0.0019 0.18 12.4 4.4 1 21 698 718 698 719 0.95
8 17 0.014 1.3 9.6 0.9 2 23 731 753 730 753 0.91
9 17 0.32 31 5.4 1.1 1 23 756 779 756 779 0.95
10 17 0.005 0.48 11.0 0.1 2 23 785 806 784 806 0.96
11 17 2.9 2.8e+02 2.3 0.2 1 23 810 833 810 833 0.94
12 17 0.27 26 5.6 0.1 2 23 840 862 839 862 0.94
13 17 0.031 3 8.5 0.5 2 23 871 893 870 893 0.94
14 17 0.0035 0.33 11.5 0.3 3 23 900 921 899 921 0.97
15 17 4.4 4.2e+02 1.8 2.3 2 23 1076 1098 1075 1098 0.94
16 17 4.1 3.9e+02 1.9 0.1 3 23 1106 1127 1104 1127 0.87
17 17 0.17 16 6.3 0.9 1 23 1140 1162 1140 1162 0.96

Sequence Information

Coding Sequence
atggaGACGAAATTGTGTCGAATATGTGGCAAGTTGGGTCAAAATttcatacatattttcaaaacggaagggttaaaaaataaaatagaaacatGCCTTCCAATTGTCATATCCCAACATTGTTTACTGCCAGACACAATTTGTGGGGAATGCTCAGAAAATGTAGACAATTTTTAcagtttcataaaaaattgtttacaaaacatAATCATATTAGAAGCTCAATACGACATTATCGAATCATGTTTAAAGACAAAAAGGAAATTTGATAAAGGCTGTTATGCTGATTTAACAGCCAGAAAATacgataaaaatatacaaactgACGATTATTTAGATGTATTACTTGGTAAATCGGGTGATATTGACTTTAATTTACCAATTACACCgcaattatttgaaaaaaacaattttttatgtgataTTGACAAGAAACCTAAAGCTTTAGTCGATTATGAAATTGAGTCTGATTCAAATTCAGACAATGatgatattattaaaaagacTACAAATAAATCCGCACTTAATGAAAACTTGGATATTATGAATAAGATTAACAATTATGTGGATTCTGTGTTATCAACAAAGAAACCACCAATGGGCATTAAACATTATTTCGATGATACTGAGAATGATTTAATCAATGAAATATCACAAAGGAagaatttgaaaagaaaatgtgatcaaattgaatttcgttcgccaaaaattttcaaaatggatACTTCGAATCgacgaaaaaataaacaaccgAAAAAGTTTGATACACGTTCTCAAAATATTGGAAATGTAGAAAATCAATTCGATTTTACAATCCCTACTGCAATAATCGAAGAGGAAAACATAAACAGCAATTCGTCTGTTGTAAATCTAGATAATCAACTTTTAAGTGATGAAAAAACCGAGCCTTTGACTGAAAAGGATTTGGTTGCCAGTTTACctcaaatttgtttattatgcGACACTCATTTCGTGGGACCGGCAGCTTTGGCTACACATGTTTTTGAAGCACATGGCATTGATATGGCACAAATTATATCTTCAATTACTGAAGCAGCCgttgaaaagaaaaagaaaattcctAAATTAGTGAAAATCTCTGATCTTAAGAAGAACGAACCATTAGATGACAATCCAATTAATGACCGTTCAGAAGAACCGCCAACGCTTTCACCCAGTTTCGTTTGTCCGAATTGTCCAGCagtattttcaacaaaaagtGATCTTTTCGTCCATTTACGTGTAAAACATACACATCAAGCATCAACATTATGTGGTATATGTTTACATCAAGCAAAtacttacataaatttaaaatcacaCACTGAAATGTGTGCTCAACAACATTCAATAAACGCTCgttatgtttgtttaatatgtCTATATGGTGATGACAATTCTAAATCATTAGAAAATCACATACTCGTTCatgaatttttattggaaTCGTGCAAAAAACAAGCAAAAATGTTTGACCCAGCAGATTATATTGGCACCAATGAAAAGTTCAATAACGATGGTGTTTTAACATCAGGCAAGAATTTAAGTTGTAGCGAATGTGGATTTAGTAATTTCACTTCATTTAAAGACTTTAGTACGCACAGACGTAGTCAACATTCCATATTTCACTGtgatttatgtaataaattttatggacGAAATTCGCATTTATGGAAACATGTAAATCGTTTACATAAAGGCCATCCAAGTATAACGTGCCAATTATGTTATAAAACGAGCGCATCAAAATATCATTTAGcacaacattttaataaaatccataGTGCGAAACCatgcaaacaaaaaaatgatttaaatcaaatcgataatgattttatgtcgCAAAAATTCCAAGCATTCGATTTTCAATCGGTTAaacaaagttttatgaaacaaGAATTAATTGAACAAGAACGTAACCGTTTTAATGTGTGTGATATGGATGATAATTCGAATAATCATTTAACAGATGATGATGacaaaattgatataaaacaAGAACCAGTGGCGGCACCAAAAGAAATCGATTCATCTAGtgatttgtatacaaatattataacgAATTATACACCACCATCGAACGATGGTGAATTTAAATGTCCAAAATGTAGTAAAGGATTCCATAAAAAGACATTATTGAAGAAACATAAAAAGAATTGCCGTCCACGTTTACAAAAAGACTTATTAACAAGATGTAAATCGTGTGCACGTATATTTAAAGATCGTCAAAGTTTGGCAAAACATCTAGTTAATTATCATTCAGAATATGCATGTGAAATATGTAATCAAAAAGTACAAAGTAAATGTGAAATTGTATCGCATATACGATTTACACATCCAAAATGCCATTTGGTATGCAAAATATGTGGTAATATATTACGTAGCCGGGCTGATTTGATAGAACATACACGAGACCATTTGAATTCGTATATTTGTCAATTTTGTGCTGATTCATTACcaagtaaaataaaactaaaaatgcaTATACTCAGCTTACATCGAAAAATACTCAGTTTAAGTTGTggtatatgtttaaaattatttgaaacacAATATATATTGAGAGATCATGTAAGATTGGTGCACCGCGATCAATTAGCCCCATTAACTTCGTGTCCAGTTTGTGGAAAGAATTACGGTTCGAAATGGAAGACTTACGATCATTTGAATAAATCACATGGAAGAATTTTCAGGGCATGTAAGACGTGTTTGGAGGTATTTGATAATGAAACACAATTGCAAACACATTATTTAACTGTTCATTCGAATCAAACAagttcaaataataataaaaacatcacACAACAATCTACATCTATGACAAATAATGCAAATGCCAATGTGTATGATAGCGATAGCGATGAACAAGACAATGATGAACAATATGATtatgataatgatgatgaaaagCAGAGTGATATtgaaaatactaaaataaatgtgaataATCATGTTAGTTTATCGCATGATacgaaaatttctttattggAAAAGAGATTATTGGGTGAAAAAGTTACTGAAGATGAAACAATAAGTAATCGATCGAAAAATGCAACAAAATCCagacaaattttaaatgatgttaaaaaagaaaagaataatGAGTTGCCATTATTAgtgaatgttaaaaaacaagAAGATGATGTTGGAAATGTGAATAATTCACCAAATCCATTACAAAATAGCTCAAAACGTACTGTCTACGTGAATAGTAATGATCCATCGTActgtgaaatttgtttaaaaacttgGCCAGCAAAAAAACATCTTTGGCAACATTATATACGTTGCCATAAGAGTGTGGCAGCTACTATATGTggtatttgtttgaaaacaaatCCGGATTATGAAAGTTTGCAAGAACATTTGATAGAAAATCATCCAACACTTTTGCACGGACAAGGTTTTGGTTCGAATTTCATCTGCCGAATATGTGGCCGTTATCATAATGCTAgttctaaattaaaattacacatGGCCATACACGAAAATTTTGATTGGTCAATTTTAGATGGACCAGCAAAGAAACAAACCACAAAACAAAACCAATCTAATCaggaaacaacaacaaaaacaacaaacggTTACACTGAAACAAAATCAGAAGAACCAACCGAAGAAATGGAAGTTTACGAGGAAAATGCTGATATTAATTATGAAAGTTTAATTGAACAAGTTGAATGTTCATCACAATCAGAAAATGATGAATCTGATGTTGAGGAACAAGAACAAATGCAAGATAAAAATGATCATCAGTCCACATCCGAAGAGGATGATGATGAAGAAGTAGATGATGACAGTGAAAATGAATCTAGTGGTTCAGAAAATGATTTAGAAACAATGAAAGACAGAATGCATGAATCGAATAATGAAgatattcaaatgaaaaatgaaatggaCGATAGGAGTAGTAGTGAGGAGAGTAATTCAAGTTTTTCGGATGATCAGAATGTGGAAGTTAAGTCGGATAATGGTTCAGAGTTTGATGGATCTCCAGAAGAATCGCGTTCAGAATCGAGTAATGGCAAATATACGATCCGTTCGAATTCTACAACGGTTGATTCGTTGTcaaatagtaatttatttagatGTAAACCAGAAGAATTGGATTCAGCGATAAAATCAATTAGTTATGAATGTATTAATCAAGTGGAAGACAATGGGGACGATGAATATTGTGATTTACAATCACATAGTCTAAATGATAACGAAATTGAATCGGCCGTTGGTAGTATACTTTAA
Protein Sequence
METKLCRICGKLGQNFIHIFKTEGLKNKIETCLPIVISQHCLLPDTICGECSENVDNFYSFIKNCLQNIIILEAQYDIIESCLKTKRKFDKGCYADLTARKYDKNIQTDDYLDVLLGKSGDIDFNLPITPQLFEKNNFLCDIDKKPKALVDYEIESDSNSDNDDIIKKTTNKSALNENLDIMNKINNYVDSVLSTKKPPMGIKHYFDDTENDLINEISQRKNLKRKCDQIEFRSPKIFKMDTSNRRKNKQPKKFDTRSQNIGNVENQFDFTIPTAIIEEENINSNSSVVNLDNQLLSDEKTEPLTEKDLVASLPQICLLCDTHFVGPAALATHVFEAHGIDMAQIISSITEAAVEKKKKIPKLVKISDLKKNEPLDDNPINDRSEEPPTLSPSFVCPNCPAVFSTKSDLFVHLRVKHTHQASTLCGICLHQANTYINLKSHTEMCAQQHSINARYVCLICLYGDDNSKSLENHILVHEFLLESCKKQAKMFDPADYIGTNEKFNNDGVLTSGKNLSCSECGFSNFTSFKDFSTHRRSQHSIFHCDLCNKFYGRNSHLWKHVNRLHKGHPSITCQLCYKTSASKYHLAQHFNKIHSAKPCKQKNDLNQIDNDFMSQKFQAFDFQSVKQSFMKQELIEQERNRFNVCDMDDNSNNHLTDDDDKIDIKQEPVAAPKEIDSSSDLYTNIITNYTPPSNDGEFKCPKCSKGFHKKTLLKKHKKNCRPRLQKDLLTRCKSCARIFKDRQSLAKHLVNYHSEYACEICNQKVQSKCEIVSHIRFTHPKCHLVCKICGNILRSRADLIEHTRDHLNSYICQFCADSLPSKIKLKMHILSLHRKILSLSCGICLKLFETQYILRDHVRLVHRDQLAPLTSCPVCGKNYGSKWKTYDHLNKSHGRIFRACKTCLEVFDNETQLQTHYLTVHSNQTSSNNNKNITQQSTSMTNNANANVYDSDSDEQDNDEQYDYDNDDEKQSDIENTKINVNNHVSLSHDTKISLLEKRLLGEKVTEDETISNRSKNATKSRQILNDVKKEKNNELPLLVNVKKQEDDVGNVNNSPNPLQNSSKRTVYVNSNDPSYCEICLKTWPAKKHLWQHYIRCHKSVAATICGICLKTNPDYESLQEHLIENHPTLLHGQGFGSNFICRICGRYHNASSKLKLHMAIHENFDWSILDGPAKKQTTKQNQSNQETTTKTTNGYTETKSEEPTEEMEVYEENADINYESLIEQVECSSQSENDESDVEEQEQMQDKNDHQSTSEEDDDEEVDDDSENESSGSENDLETMKDRMHESNNEDIQMKNEMDDRSSSEESNSSFSDDQNVEVKSDNGSEFDGSPEESRSESSNGKYTIRSNSTTVDSLSNSNLFRCKPEELDSAIKSISYECINQVEDNGDDEYCDLQSHSLNDNEIESAVGSIL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-