Basic Information

Gene Symbol
PRDM10
Assembly
GCA_000612105.2
Location
NW:55654-63594[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 3.3e-08 1.7e-06 27.2 1.3 1 23 519 541 519 541 0.98
2 13 0.00057 0.03 13.9 1.5 1 23 549 572 549 572 0.98
3 13 0.035 1.9 8.3 0.2 2 23 590 611 589 611 0.95
4 13 0.00032 0.017 14.7 0.2 2 23 625 646 624 646 0.95
5 13 0.027 1.4 8.6 4.5 1 23 663 685 663 685 0.91
6 13 0.0032 0.17 11.5 2.1 2 23 694 715 693 715 0.96
7 13 0.01 0.53 10.0 0.1 1 23 722 744 722 744 0.98
8 13 0.00064 0.034 13.7 2.1 1 23 751 773 751 774 0.96
9 13 0.011 0.61 9.8 1.6 1 23 779 801 779 801 0.98
10 13 1.9e-05 0.001 18.5 4.1 1 23 807 830 807 830 0.96
11 13 0.018 0.94 9.2 2.0 1 23 863 886 863 886 0.97
12 13 2.9e-05 0.0016 17.9 2.4 1 23 908 931 908 931 0.97
13 13 0.003 0.16 11.6 3.4 3 23 969 990 969 990 0.98

Sequence Information

Coding Sequence
ATGGATCCAAGGGGCCCTCCTGAGGGGGCCCCTGGCGATCCATTGGACATTTCCCTGGTGTCGGATAAGACTTCGGATATCGCGGATTCCTGGTCCATAGATCACTCAGTTTCCTCGCCGTTGTGCGATCAACCTAAGAAGATGAACAACAGACTTCTGTTTTTGGCGGTCGAGTACGTGGATGAACAGCCGAAGGATTATTCTCGTATTTTTCCGGCCTATGAACAGGTTTCCTTCTCCCCAAGAACCTCCTCTCCGTTGTCTGATTTCGAGCACCGAGTGAGCCCCTTAGATCCAAATATGAGTTCCACTGCGAGATATTCACCAACTCCGGTGCAATTACCTCCATCCCCTTTCCAAAACTCGGTTGTCGTCCTGCAAAATCCGTCTTCCCCTATGATTTGCCCACCTGAGACGAATGCTCGAGCGGGCATTAATTACGTGTCGCAGCTGACTGACCAGAACAATGTACAAAGCATACCGCAGTCTGGTACTGGCACAGATTTCGTTGACAGATCTACTGACGAGGAACTCGTTACCGAGGTTGAAGGGGAACTGATCTTGGTACAAGGCTCAACCCCTGATTTGGAACCATCCGCTGCACCGCTCATGTTAACAGGGATACCGAATACAGATTTTGCATTGACTAGAGATTTTCTGGTAATGAACGATGATCAAATAAATGCCATGGGATCGTTGAGGAACCAAAGTTTGGAGATCGGCGATGGGGATGTCATAACTCCTACGCAAACAATAAATGTTCGTGATGCGGCGGTGTCGCCTAAAAAGGAGCCGTCACGGGTTTTTGATGAGATTTTATTAGGATCTGAAGtagaaaatgagaaagagTGTGTCAGAAGATCCAAGCGCATAAATGACAGGAAAGCATTCTGGTGTGACGAATGTAACAGTATTTGCGAAAATGCGAACGATTGCACTTCACACAATGTGCATACTATAGCGGATCAACCAGTACCCTCGAGGGCTATTGCAACACTGCCAGGATCATATCTATCTATTAATAAGTTACCATCGTCACAAGTCTTACAAGGTGGCTTGGAGTATGGAGTCTTTGCTAAGCGTAACATAAGGAAGCGTACACAGTTTGGTCCTATCGAGGGTATCCTGTATGTCTACGATCAGACACCTTTTATTAATGTCTTGCCACTACTTTACGAAACAGCTGATGGAAAGTTCATGAAAGTCGACGTATCGAATGAACATGCATCAAACTGGATGCGTTTTGTGAGGCCTGCGATAAGCTACAAGGAGCAAAACCTGGTAATTTGTCAGCAAAACGATGGAATCGTATTTCTGACAACAAAAGATATTTTACCGAAGGAGGAATTAAGGGCTGGTCCCAGTTCCGACTATGCAATCCGTAGAAACTTGCAAATTCTCAAACCAGAcataaaggaggaaaaagagGGCCTTCGTAAACATCCAAACGGTCACAACTCTTCCATAACCGAAAGCAAGCAAAAGAAGAAGCGCAAGGAGATTCACATCCCGTCCAAGAAATTCTTTAAGATCGTGGATGGCCAGACTCTCCTCTACACGTGTCCACACTGTCCAAAAGTATTTCCTCGGAGTTACAGCCTAAAACGACATTTACTGATCCACCCAGGTGCGAAGGCACCTCGTTACGAGTGTCCCACGTGTGGTGAGAATTTTTTGCATCCTTACAACCGCAGTCGCCACATGAAAATCTTCCATGGTGCGGAcccgaaagagaaggagaactCCAGGCAGAACACGATGGAGTGGAAGTGCCGAACCTGCACCCTGGCCTTCGGGAAAGCATCATTGCTCAATTTACACAGCCTAGTACATAAGGCGGATAGTCTGGAAGCAGGAAAGGGTCAATCTTCCGTCTGCCCCCAGTGCGGCACCGAATTTAAAAAGCGAATTGATCTTATCAATCACGTCTCTCAACATGGTCGACTTCAGCTCTCGAAAGCTGGTAAATTGAACACTCTCGCTGCATACAAATGCTCACGATGCTACAAGCGATTCGCAACCAAAGTGCGATTACAGCAACACTGTCTAGTTCACGGAGCTGAAGATCAGAAGCCCCTGCCCTGCGAGATTTGCAGGAAGCGATTCATGAATAACTCCGCTCTCTCCTGTCATCTGAAGACACACAGAGCAGACAAACAGGTGTTTGAGTGTCCGATGTGCAGGCAGTTATTTGACCAGGTCTTGATGCTGAAGGACCACATCGAGACTCATCGAAACGATGACGAGACCTTCACTTGTCCCTACTGTCTTAGGTCCTTTGTCAAGTATTCCGTAATTCGCAAGCATATCAGGGCTCACCATTGCGAAAGGAAGCATACTTGTCAGTTGTGCGCGAATCGTTTCCCCACGGTTGACAAATTGCGCATGCACATGTTGCGGCACTCCGATTATAGAGAATTTCATTGCGCAAATTGTGGGAAGCAATTCAAAAGGAAGGATAAATTGAAGGAGCACATGACTCGGATGCACAACTCGGACAGAGCAAACCGGGAACAGGTGGCACAAACTCAGTCTGCTAAAAAATTCGTACCAAAGGTTAATCCAACGGATTACAATCGCTTCGTATACAAGTGTCATCGATGTATGGTGGGTTTCAAACGAAGAGGCATGCTCGTCAACCACCTGGCCAAGAGGCATCCAGACGTCCCTCCAGAATCCGTGCCAGAGTTAAATCTACCGATATTAAGACAAACGAGGGATTACTATTGCCAGTACTGCGACAAGGTCTACAAGAGCAGCAGCAAGAGAAAAGCTCATATCATGAAGAACCATCCTGGGGCAGCAGTGCCTCCGAGCAATCGCCAGAAGGAGTCGGACATTTCAGGTTTGCCGAACCCAACTTTCAGTCAGACGGTGGGCAGCATAACGACGACTCCTCAGGGTTGTCAATGGTGCCACAAACAGTACGCGAGTAAGGCGAAATTGCTGCAACATCAGCGCAAGAAGCACCCGAACCTGATGGAGCCCGCGGACCAGGTTCCTCGTCCGAGGAATCGTCCTCCTCAGAATCAAAACCAGCCTCCGGCTCTCGGGGAAAACTTCCTGATAGCCGAGTACGTCCAGCCCTGCGACCTGGAGCAGAGTTTCCTGAAGACAAAGATAATAAAGCTGTCGAACGACGTGGACCTGGTGACCAACGGTTACGAGATGGTCGGTCAGCAATTCGTGCGGATGCGCGACATACGTTGA
Protein Sequence
MDPRGPPEGAPGDPLDISLVSDKTSDIADSWSIDHSVSSPLCDQPKKMNNRLLFLAVEYVDEQPKDYSRIFPAYEQVSFSPRTSSPLSDFEHRVSPLDPNMSSTARYSPTPVQLPPSPFQNSVVVLQNPSSPMICPPETNARAGINYVSQLTDQNNVQSIPQSGTGTDFVDRSTDEELVTEVEGELILVQGSTPDLEPSAAPLMLTGIPNTDFALTRDFLVMNDDQINAMGSLRNQSLEIGDGDVITPTQTINVRDAAVSPKKEPSRVFDEILLGSEVENEKECVRRSKRINDRKAFWCDECNSICENANDCTSHNVHTIADQPVPSRAIATLPGSYLSINKLPSSQVLQGGLEYGVFAKRNIRKRTQFGPIEGILYVYDQTPFINVLPLLYETADGKFMKVDVSNEHASNWMRFVRPAISYKEQNLVICQQNDGIVFLTTKDILPKEELRAGPSSDYAIRRNLQILKPDIKEEKEGLRKHPNGHNSSITESKQKKKRKEIHIPSKKFFKIVDGQTLLYTCPHCPKVFPRSYSLKRHLLIHPGAKAPRYECPTCGENFLHPYNRSRHMKIFHGADPKEKENSRQNTMEWKCRTCTLAFGKASLLNLHSLVHKADSLEAGKGQSSVCPQCGTEFKKRIDLINHVSQHGRLQLSKAGKLNTLAAYKCSRCYKRFATKVRLQQHCLVHGAEDQKPLPCEICRKRFMNNSALSCHLKTHRADKQVFECPMCRQLFDQVLMLKDHIETHRNDDETFTCPYCLRSFVKYSVIRKHIRAHHCERKHTCQLCANRFPTVDKLRMHMLRHSDYREFHCANCGKQFKRKDKLKEHMTRMHNSDRANREQVAQTQSAKKFVPKVNPTDYNRFVYKCHRCMVGFKRRGMLVNHLAKRHPDVPPESVPELNLPILRQTRDYYCQYCDKVYKSSSKRKAHIMKNHPGAAVPPSNRQKESDISGLPNPTFSQTVGSITTTPQGCQWCHKQYASKAKLLQHQRKKHPNLMEPADQVPRPRNRPPQNQNQPPALGENFLIAEYVQPCDLEQSFLKTKIIKLSNDVDLVTNGYEMVGQQFVRMRDIR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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