Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.00047 0.045 15.0 0.6 2 23 5 27 4 27 0.95

2 7 0.11 11 7.5 0.5 3 21 41 59 40 64 0.94

3 7 0.058 5.5 8.4 0.3 2 23 115 137 114 137 0.95

4 7 2.3e-05 0.0022 19.1 1.3 1 20 152 171 152 174 0.94

5 7 2.2e-06 0.00021 22.4 4.0 1 23 180 202 180 202 0.98

6 7 5.6e-07 5.3e-05 24.2 2.4 1 23 209 231 209 231 0.96

7 7 3.8e-05 0.0036 18.4 1.1 1 23 237 260 237 260 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.00047	0.045	15.0	0.6	2	23	5	27	4	27	0.95
2	7	0.11	11	7.5	0.5	3	21	41	59	40	64	0.94
3	7	0.058	5.5	8.4	0.3	2	23	115	137	114	137	0.95
4	7	2.3e-05	0.0022	19.1	1.3	1	20	152	171	152	174	0.94
5	7	2.2e-06	0.00021	22.4	4.0	1	23	180	202	180	202	0.98
6	7	5.6e-07	5.3e-05	24.2	2.4	1	23	209	231	209	231	0.96
7	7	3.8e-05	0.0036	18.4	1.1	1	23	237	260	237	260	0.92

Coding Sequence: ATGTCTGCCTGTGTTTGTGAGTTGTGCGGCTACACGTTTGTGAGTAAAATTGGTGTCGAGGTACACAAGAGGATGAGGCATAAGCTGTTTGATAAGAATACGGAATTCAAGGGACAATTCTGTGAGGTTTGCGAAGTGAAGTTCTTGACTCAGAAGGCTTACAACAGACATCTGCGATTATCTGCCAAACATATTAAAGAGGACGATCCCAATCGCATGAGCAACGACCCGTCCATCAAACAGCGTCGCCTGGGCGCTTCGTATATGAGAGACACGCGCTCCCGCCGCCCCGTCATACACCGCAGAGACCCGAACACCGAGCCAGCAGCTAACGGACCCATCACTTGTGAACAGTGTGGCGTGGTACTAGAAAACCTCCGCTCTTACGCGGCACACTTCAGACACTCGCACCCCGGCATCAATCGCACGCAGTTCGACAACACCAAGACGCCGTACATGTGCGAGCACTGTGGCAAGTTCTTCAACAACACAACAACCCTATCTGCCCACATGTGGGTGCACGACGGTCAGAAACGTTTCCAATGCGACCACTGCCACAAGTCGTTCACAATGAAGGCGAACCTCGCCGGCCACATGCAGCAACACCAGGCCGTAAGGCGGACGTACGACTGCCGTGTGTGCGGGAAACGCTTCACGTTCAGCTACAACCTCACCCGGCATATGTTTCTGCACACAGGCCTTCGCCCCTTCAAATGCGACGCGTGTGAGAAGACGTTCCGAACAAGCGGTGAACTGCGCTCTCACGTAGACCATGTACACTTGAAGAAACCTCGACCCAAGCGCGTCAGACGGAAGGTGAAGAAACTTGAGATGCCTAACTTAGAGTACTGA
Protein Sequence: MSACVCELCGYTFVSKIGVEVHKRMRHKLFDKNTEFKGQFCEVCEVKFLTQKAYNRHLRLSAKHIKEDDPNRMSNDPSIKQRRLGASYMRDTRSRRPVIHRRDPNTEPAANGPITCEQCGVVLENLRSYAAHFRHSHPGINRTQFDNTKTPYMCEHCGKFFNNTTTLSAHMWVHDGQKRFQCDHCHKSFTMKANLAGHMQQHQAVRRTYDCRVCGKRFTFSYNLTRHMFLHTGLRPFKCDACEKTFRTSGELRSHVDHVHLKKPRPKRVRRKVKKLEMPNLEY

Sequence clustering based on sequence similarity using MMseqs2