Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.0043 0.86 12.2 1.1 1 23 103 126 103 126 0.96

2 7 0.0048 0.95 12.1 0.1 2 23 152 174 151 174 0.96

3 7 0.15 29 7.4 0.3 2 23 197 218 196 218 0.97

4 7 0.00072 0.14 14.7 0.4 1 23 222 244 222 244 0.95

5 7 0.0061 1.2 11.7 1.3 1 23 249 272 249 272 0.90

6 7 0.04 8 9.2 0.4 2 20 280 298 279 302 0.85

7 7 0.00018 0.037 16.5 1.6 2 23 310 332 309 332 0.94

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.0043	0.86	12.2	1.1	1	23	103	126	103	126	0.96
2	7	0.0048	0.95	12.1	0.1	2	23	152	174	151	174	0.96
3	7	0.15	29	7.4	0.3	2	23	197	218	196	218	0.97
4	7	0.00072	0.14	14.7	0.4	1	23	222	244	222	244	0.95
5	7	0.0061	1.2	11.7	1.3	1	23	249	272	249	272	0.90
6	7	0.04	8	9.2	0.4	2	20	280	298	279	302	0.85
7	7	0.00018	0.037	16.5	1.6	2	23	310	332	309	332	0.94

Coding Sequence: ATGGCGGAGCGTGGCATAACGACGTGGCGCTCTACACTGAGTGGTGCCCATGTGGTGCCAGAGTTTTCTCCAGAGTACCTACTAAAAATAGAGGCAACAAGGAAACTGAAGAAACATGTTATAACGATTACGGGGAACAAGACGAGGAGTAAGAAGAAAGGTATCATCCTAATTAATCCTGacaatctaactgacggacaggtaacattaaaaagaaaaacagaagTGGATAAACATAAGGATAACATCAGAACTATTTTGCACCACTCTAATGCCACGCCGATAGGGAAGTATGCTGGGATCGGGTACTCATGCAGCTTTTGTCCTCAACAATATGAAACCACCACTGAACTTAAGACTCACACAATATCCCAACACGATAGCTCAAAATCGACCTTCATGGAAGAAAAAGCGATGCACAATTATATCATCAAATTAGACATTACTTATTTAAAATGTGGTATATGCCAAACGAATCTTGATACTTTAGATCAATTAATCGAACACCTGAAATCGGCACACCAAAAATTCTTCCATGAAGGACTCAATAATCATATTTTACCGTTCAAATTCGACACCGATATGTCGAAATGCGTGTTCTGTGATAATGTTTACGGCAATTTCAAAGTATTATTAGAACATATGAATTCACATTATAGAAATTATATTTGTAATGTGTGTGATGCCgggtttgtaaacaaaaaaactttactcACACACTCCTATAGACATAAAACTGGAGTTTTCAACTGCTCATATTGTTCTAAAGTTTTTAACAACAATATCAAGAAAAGGGATCACGAGAAAGCAGTACACATTTGTATGAATAAGAGGAATAAGTGTGGATATTGTGGCGAGAAGTTCAATGATTATACGAAGAAAAATGTTCACGAAGTGTTAGTGCATGGCGCGAAACCTAGAGTTTTGAAATGTCAAGCTTGTAACAAAACCTTTGACAACCAGAGGTCTCTGACAAGTCATACAAAGGCCTACCATTTGATGGAGAAGCATACCTCGAAATAA
Protein Sequence: MAERGITTWRSTLSGAHVVPEFSPEYLLKIEATRKLKKHVITITGNKTRSKKKGIILINPDNLTDGQVTLKRKTEVDKHKDNIRTILHHSNATPIGKYAGIGYSCSFCPQQYETTTELKTHTISQHDSSKSTFMEEKAMHNYIIKLDITYLKCGICQTNLDTLDQLIEHLKSAHQKFFHEGLNNHILPFKFDTDMSKCVFCDNVYGNFKVLLEHMNSHYRNYICNVCDAGFVNKKTLLTHSYRHKTGVFNCSYCSKVFNNNIKKRDHEKAVHICMNKRNKCGYCGEKFNDYTKKNVHEVLVHGAKPRVLKCQACNKTFDNQRSLTSHTKAYHLMEKHTSK

Sequence clustering based on sequence similarity using MMseqs2