Basic Information

Gene Symbol
grau
Assembly
GCA_963978525.1
Location
OZ021694.1:8277755-8280131[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.25 19 6.1 0.7 6 23 233 250 233 250 0.98
2 9 9.1e-06 0.00067 20.1 1.2 1 22 256 277 256 279 0.90
3 9 0.0012 0.091 13.4 0.6 1 20 287 306 287 309 0.93
4 9 0.13 9.7 7.0 0.4 1 23 317 342 317 342 0.92
5 9 0.0044 0.33 11.6 1.7 2 23 348 369 348 369 0.97
6 9 0.7 52 4.7 0.8 2 23 378 401 377 401 0.90
7 9 0.00037 0.027 15.0 3.2 1 23 408 431 408 431 0.96
8 9 4.4e-06 0.00033 21.0 0.4 1 23 436 458 436 458 0.97
9 9 8.9e-05 0.0066 16.9 3.9 1 23 464 487 464 487 0.98

Sequence Information

Coding Sequence
ATGGCTTGCGGAGTATGTTTGAGGAAATCAGTAGATACCATGAGTATATTTAGTAAGGAAAATCAGCACTTGAAGATATCCGACATTGTACACAAGCATCTTGGCTTCATGACTCTTTCAGATAATACCACAACAGTTATATGCACAACATGTTGGCTGAAACTTTGCGATTTTCATGTATATTACGAACATGTGGAAAATGTTCAAATTGAATACGGAGAATTGCGGAAGCAAGCCAACAAGAATATAATGGATATTAAATTGGAACAGGACTTATTCTTACACGAACCAATGGATattgaaatggaaaatattaccAGCGCAAAAGCTAATCCTACATTTAATGCAAAGGCTGCAGAAAATCCTTTGGATGAAACCACAATGTTTCCTTTGGTGTGCTTCAGTGGGCGTAGTTCTGAAAATGAatgcttaaattttttgaaagcaAAAAGTAAACTAAAGCATATAAAATGCAAACGTATTACCAAGAATAACAAAAAGTCAACGCTGAAAAAAGTTAAACAGCATAATAACAAAGTCAACACCAGCAAGTTGGATTCAAATGACATGGACGCCTTAATAAATAAGCATATAATTATGGCTTGCGATTTATGTGTGTTCATGGGCCAATCGTTTGCCGATCTAAAGGAGCATTTCCTTAAGGAGCATCCCCAGGAGAATCCCTATGTTATGTGCTGTGATCGTAAATTGACGAAACGTTATTATTTGACACAGCATGCTCTAAAACATGATGATCCCAATCACTTTAAATGCACGGAATgtcaaaaaacattttctaataATCGAGGTTTGCGTGCCCATAATTTGGCTTATCATGTTCCAGACGAGGAGAAGTTGTACGTGTGCGAGATGTGCCCGCAAAAATTTGCCACCAAACATTTATTGGATTTACACCAACCCTCGCATATATCGCGTGAAGAGAGatcttttttttgcaataaatgtCCCGTCCAGCGAGCTTTTGCTAGTGAATACTTGTTGCAAATACACAACAGCATGAGACACAACAGGGAGACGAACGTATGTCATGTGTGTGCCCGGTCTATACGGGATAAGCGGTCTTTTGAAAAGCACGTGCGCCTTCATTTTGAGGATAGCGGTCCAAGGCTTAAATGTCCGTATCCCAGCTGCGAGAGTTACCTTAAAGATGAAgagaatttaaaattacatCTAAAGCATCACAATCCAGAAGGAATCATTTACAAGTGCAACGAATGCGGCAGAGAATGCAAAAGTCGTGTAGCTCTGAGTAGTCACAAGAAATATACTCATTCAAATAAAGTGTTCCCTTGTGAACGATGCGGCAAATCCTTCAAAAAGGCCATTACTCTGAagGAACACATGGCTCAGCATACGGGAGAAACTCTATATAAATGTCCGTTCTGTACGAGAACTTTCAACTCAAATGCCAACATGCATGCACATAAGAAGAGAATGCATCCCATAGAATGGGATGAATGGCGAAAATCGAAACGTTCCAGCGCTCAAAAAACAATCACCACCCATATATCAAATACTATgtaa
Protein Sequence
MACGVCLRKSVDTMSIFSKENQHLKISDIVHKHLGFMTLSDNTTTVICTTCWLKLCDFHVYYEHVENVQIEYGELRKQANKNIMDIKLEQDLFLHEPMDIEMENITSAKANPTFNAKAAENPLDETTMFPLVCFSGRSSENECLNFLKAKSKLKHIKCKRITKNNKKSTLKKVKQHNNKVNTSKLDSNDMDALINKHIIMACDLCVFMGQSFADLKEHFLKEHPQENPYVMCCDRKLTKRYYLTQHALKHDDPNHFKCTECQKTFSNNRGLRAHNLAYHVPDEEKLYVCEMCPQKFATKHLLDLHQPSHISREERSFFCNKCPVQRAFASEYLLQIHNSMRHNRETNVCHVCARSIRDKRSFEKHVRLHFEDSGPRLKCPYPSCESYLKDEENLKLHLKHHNPEGIIYKCNECGRECKSRVALSSHKKYTHSNKVFPCERCGKSFKKAITLKEHMAQHTGETLYKCPFCTRTFNSNANMHAHKKRMHPIEWDEWRKSKRSSAQKTITTHISNTM

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00384830; iTF_01114534;
90% Identity
iTF_00384830; iTF_01114534;
80% Identity
-