Basic Information

Gene Symbol
Zfa
Assembly
GCA_963978525.1
Location
OZ021692.1:10263433-10266281[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.033 2.4 8.9 0.2 1 21 206 226 206 227 0.94
2 12 0.0001 0.0075 16.8 1.9 1 23 318 340 318 340 0.99
3 12 4.6e-07 3.4e-05 24.1 0.4 1 23 346 368 346 368 0.99
4 12 1.2e-06 9.1e-05 22.8 1.1 1 23 374 397 374 397 0.95
5 12 0.016 1.2 9.9 4.1 1 21 403 423 403 425 0.95
6 12 6.7e-06 0.0005 20.5 2.7 1 23 431 453 431 453 0.99
7 12 6e-05 0.0044 17.5 2.1 1 23 459 481 459 481 0.98
8 12 8.7e-05 0.0065 17.0 1.2 1 23 489 512 489 512 0.97
9 12 0.00063 0.047 14.3 0.2 2 23 519 540 518 540 0.96
10 12 0.00049 0.036 14.6 1.2 1 23 546 568 546 568 0.98
11 12 3.4e-06 0.00025 21.4 0.8 1 23 574 597 574 597 0.97
12 12 4.5e-06 0.00034 21.0 4.7 1 23 611 633 611 633 0.96

Sequence Information

Coding Sequence
ATGGCAGAGGAAGCGGAAGATCAACAAATAGAAGCCTACATAGGAGCATTGGATGAAGATTGGACTGAAGAAGGggaggaagaggaggcagaagACGACGTTGTCCTTACCTCAGAAGCACTTGAAGCTTTGGCTGATGTGGATGCTGTAACCAAGCATGTATTCCAAGGTGATACTAATGGTGACGATGCTAATGAAACAAATGGTACCATAATCATGGATGCCGATggcaattattattttcacacCTCAGAAAAAACAATCGAGGTAAaacctttaaaatttaatgattcGTCAAAGTTGATCAAAATTCAAAGTGCtacagtaataaaaaaaggtatCAAAGGATTCAAAGTTGATGAAGTAGCAAAACATTCAAAAGCAGCCGCCAAAAAGAAtggcaataaaattaaaattaacggGAATATTATTGCAGGAGATCAAAAGTCAACTACGGacgaaataaatacaaatcaaACTGACCTAAATGCCTACGAATTAATCATCCCCGAAACAGAAGCAGAGTTTTatgctttaaataaaacaagcacCAATGAGGTGGACCAACAGGATACCACAACTGCCACTGATGCAGCAATTCATACTATGACTGTGTACGATTGTAAGAATTGTACGTTTAAAACCAACAGTGCAGACTTGTTGGAAAATCACTTGGAAACGTgcgaaaaaattaaagaagaaaaaaaacaagaaacagCGGTACTGGTAAAACCCAAAGTTGGACGTCCAAGTAAAAAGTACAGTTCGAGCAAGAATAATGAGAAGAGAAAAAACACAACTTCAtctaagaaaaaagaaaaacaacaacatgatgAATATATGCATGATGAATATGAAGTTAACGATCTCGACTACAACCCCGAAAATGAAGTTGAAGTACGTTCGGAAGCGTTAATGAAATCTATAACCAGTGACGCACCAAGTGAAGAATTCAAATGTCCGCATTGTCCGTATGTGGCACCAAAGAAATTCTCTTTGTCGCGTCATCTAAAAACACATTCCGATGATCGGCCCTACAAGTGTTCCATATGTGAGAAAGGTTTCAAAACAGCCGCTTCACTACAAAATCACGTCAACACTCATTTGGGTAATAAACCACATGTGTGCGGTGATTGTGGCAAATCGTTTACAACCTCGGGAGAGTTGGTGCGCCACTCACGCTACCGTCACACGGGTATTCGGCCCCATAAGTGTACAGAGTGCGATTACGCCAGTGTGGAGATGAGTAAGTTGAAGCGTCACATGCGCTGCCATACGGGCGAAAGACCGTACCAGTGTCCACACTGTACATATGCCTCGCCCGACTCGTTTAAATTGAAACGTCACATGCGCACGCACACCGGCGAAAAGCCCTATGAATGCGACATATGTCATGCTCGCTTCACACAATCGAATTCTCTTAAATATCACCGTTTAATACACTCGGTGAATGAGAAGCCGGTGTTCCAGTGTCCCATGTGTCCCACCACATGTGGCCGCAAGACAGACTTGCGCCTGCATATACAAAACCTGCATAGTACAGATAAAGCGTGGCCTTGCAATCGCTGTGGCAAAGAGTTGCCGGATCGGTACAGTTACAAAATGCACATAAAATCGCATGAAGGTGAAAAGTGTTTTCAATGCAAATATTGTCCGTATGCTTCAGTTTTGCAGCGCCACCTCACCATACATATGCTGCTACATACTGATGAAAAGCCATTTAAATGTGATACATGCGATATGCCCTTCCGCCAAAAGATGTTGCTGCAACGTCACATCAACGTCTATCACACTGGCGAGTATGTACCGCCGAAGCCGCGGGAGAAATCGCATGCTTGTCCACATTGTGAAAAGACATTCTGCTTCAAAGGCAATTTAATACGTCACATGGAAGTACATGATCCCACATCAGCCGTGGAACAGCGTCAATTTGAATTAAAGTTGGGTCGTTTAATTCGCGTTAGCGatgaaaagaataaaatgaacGAGGATGCCGAAGTGGCTGCAAACGGTGGTGGTGATTACAATGAAGCAGACGATGATGAGGCGGCAATTGTGGAATCGTTGGTTGATCATAATGAATTGGAATACCACAATGAAGTAGCGGATGATGAGAATGATGAAGAAGAGGAGGCCTATTATTTATACGAAGAAATCGAAGAGGACGAAAAACCCTCACTAATGAATTCtctagaaaatgaaaataaaatcatatcaCAAATAAAACCAACAGCAAAACTAACTATAGACAAAGTAAAAACGGAAAAGGAACAATTGAATAATGTCAAAGTAGAAAAAGAGACGTCcgataatgttgttgttatagaaaTAATGCAATGCGCGGATGAGACTTTAATGGAGGTGGAAGAGGAAACTAATCTTATGGAAACATCAGAAGTaggagaagaaaaagaaaactacaAGAAGAAGTTGAAAACACTTGAAATTATAGATAATACTAAAAATAATACCGTTATTTTtgagGAAGAGGCTAATGCCGAATTAATGGATGACGAACAAcgtattgaattttttgaaataactGAAGCTAATTAA
Protein Sequence
MAEEAEDQQIEAYIGALDEDWTEEGEEEEAEDDVVLTSEALEALADVDAVTKHVFQGDTNGDDANETNGTIIMDADGNYYFHTSEKTIEVKPLKFNDSSKLIKIQSATVIKKGIKGFKVDEVAKHSKAAAKKNGNKIKINGNIIAGDQKSTTDEINTNQTDLNAYELIIPETEAEFYALNKTSTNEVDQQDTTTATDAAIHTMTVYDCKNCTFKTNSADLLENHLETCEKIKEEKKQETAVLVKPKVGRPSKKYSSSKNNEKRKNTTSSKKKEKQQHDEYMHDEYEVNDLDYNPENEVEVRSEALMKSITSDAPSEEFKCPHCPYVAPKKFSLSRHLKTHSDDRPYKCSICEKGFKTAASLQNHVNTHLGNKPHVCGDCGKSFTTSGELVRHSRYRHTGIRPHKCTECDYASVEMSKLKRHMRCHTGERPYQCPHCTYASPDSFKLKRHMRTHTGEKPYECDICHARFTQSNSLKYHRLIHSVNEKPVFQCPMCPTTCGRKTDLRLHIQNLHSTDKAWPCNRCGKELPDRYSYKMHIKSHEGEKCFQCKYCPYASVLQRHLTIHMLLHTDEKPFKCDTCDMPFRQKMLLQRHINVYHTGEYVPPKPREKSHACPHCEKTFCFKGNLIRHMEVHDPTSAVEQRQFELKLGRLIRVSDEKNKMNEDAEVAANGGGDYNEADDDEAAIVESLVDHNELEYHNEVADDENDEEEEAYYLYEEIEEDEKPSLMNSLENENKIISQIKPTAKLTIDKVKTEKEQLNNVKVEKETSDNVVVIEIMQCADETLMEVEEETNLMETSEVGEEKENYKKKLKTLEIIDNTKNNTVIFEEEANAELMDDEQRIEFFEITEAN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00384717;
90% Identity
iTF_00384717;
80% Identity
-