Basic Information

Gene Symbol
-
Assembly
GCA_900474385.1
Location
UCOM01001167.1:37745-47664[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.044 4.3 8.3 2.6 1 23 52 74 52 74 0.94
2 13 0.62 60 4.7 8.9 1 23 91 114 91 114 0.97
3 13 0.0013 0.13 13.1 0.4 1 23 133 156 133 156 0.94
4 13 0.034 3.3 8.7 0.3 3 20 161 177 159 179 0.88
5 13 2.2 2.2e+02 3.0 0.4 12 23 199 210 187 210 0.81
6 13 0.03 3 8.8 4.0 1 23 224 247 224 247 0.97
7 13 0.0025 0.25 12.2 5.0 2 23 260 282 259 282 0.95
8 13 0.11 10 7.1 0.5 3 21 287 304 286 305 0.82
9 13 0.00014 0.014 16.2 5.5 1 23 313 336 313 336 0.95
10 13 7e-05 0.0069 17.1 0.8 3 21 344 362 342 363 0.92
11 13 0.061 6 7.9 0.2 2 14 494 505 493 513 0.76
12 13 0.5 48 5.0 0.5 3 23 525 546 524 546 0.96
13 13 7.4 7.2e+02 1.3 1.0 1 8 556 563 556 563 0.90

Sequence Information

Coding Sequence
ATGAGTGAACTTAGAGAAAGTCAAGTTGTAGCTCGTCCATTAAAAGATTTCAACGAAACAATTCACTTGCATTGTGGACTTTGTCTATCAACCAtcgcaaaaataaacattgaagAGTTCGAAATCTGCCAAGTTTGTTCGAACCCACTTCAGTATCAATGTGTAAAATGCGGTACTGGTTTCCGAACCTTAGAGTTTTGCATGCAACACCAAAACGATCACTGTTATTTAAAAGACAAGAACAAATCCATGTCAAACGTAGGTGTGAAATTCAAGTGTCACCACTGCCTCTTctcatcgaaaaaaattcattacctcAAAACCCACATTTTAATGAAGCACGATTCGACAAACTGTCATAACATTGACCCAAACAGGTTCGAAAGCCACGAGATCTTCTACTGCGACGACTGCAACTATTCAACCAACGCAAAAGCCAACATGCGCGTACACATGGAGGGCAAACATTTAATGCAGAACTGTCCAAAGTGCAGCAAAACCTACAAGGTCAGGTCCCTTAAAGCTCACATGGTTAGGTGTGCAGGAGTATGGAAGAAACTAACCTGTTTCCTCTGTAAGAATTTTAACGCTGAGCGTAGTATAGATATGACCAGGCACATGCTGACACACTTCCAGGATGGAGGTTCGAAGAACGTGGAACCGAACAAATTCAAGTGTCCGCAGTGCAGTTTCAAAACCGATTTCAAGAACTATCTGAAGGTGCACAAGCGGAACAAACATTCGGCAGGGAAACTCTTTGAACAGCAGGACACTTTGCACTGCGAGCACTGCGATTACCGGACCAAGTACAAGAATGACCTGGCCAAGCATCTCAGATATAGACATACCTTTGTCGATTGCAAGATTTGCGGACAGACGTACAGATATCAGAACATCTTCCAGCATCGGCAAACCTGCGGTAAGAATGAGAAGCCCTACAAGTGCACTATTTGCGATTATGCTTGTAGACGACCACATCATTTGAAGCTACATTTGACCAATGTTCACGTGACACATCCCAGAGTTAATTGCAATAATTGTGACAGGAGCTTCAAGAATAAGGCGAGCATGAAACGGCATGCCAAGAATAAAAAATCCAAGAGTTCAATTGAGGAAGATCCACTTTTAACTGGTACCGAAAATGATGCTGAATCTTCTATGATAGCGGAAAGTGACGGACCATCATTTATTGTAACAGAAAGTGATACATCCACGTCTATTGTAAATGAAACTGACGGTACCACTATTATCATTGCCAAAGATGGCCTCAATTCTATTCTGCCAGAAAGTATTGTTCCAGATTGCATTACGCCACAAACTGAAGCTGCGGCATCAATTCTACCGGAAAGTATTATACCCGACTTTATTCTTAAGCctaaaaatgaagaatgtATCGCATCAGAAAATGAAGCTGCTGCTCCTGTGCAATCGAAAAATATAGCAATACCTTCCACCTCCAGAGAATGGAAACAATACATGAAGTGTCCCAGatgtgaaaagaaattttcgacGAATTTAATAAGAGCACACCTTCGACTTtgcaaagaaaagaagaagccCTTTTTCTTACTATGTTCACTATGTCCTTTTAAAACGACAAAGACGGGCTCCTTTATAGAACACGTAAAAATCACTCACGGAAGGACGACGGAAGAGCACAAGTATCACAAATGTCCCAATTGCGATAGATGGGTAGAGTATCACATAATAGATTCTATTATGGAAGGTTGA
Protein Sequence
MSELRESQVVARPLKDFNETIHLHCGLCLSTIAKINIEEFEICQVCSNPLQYQCVKCGTGFRTLEFCMQHQNDHCYLKDKNKSMSNVGVKFKCHHCLFSSKKIHYLKTHILMKHDSTNCHNIDPNRFESHEIFYCDDCNYSTNAKANMRVHMEGKHLMQNCPKCSKTYKVRSLKAHMVRCAGVWKKLTCFLCKNFNAERSIDMTRHMLTHFQDGGSKNVEPNKFKCPQCSFKTDFKNYLKVHKRNKHSAGKLFEQQDTLHCEHCDYRTKYKNDLAKHLRYRHTFVDCKICGQTYRYQNIFQHRQTCGKNEKPYKCTICDYACRRPHHLKLHLTNVHVTHPRVNCNNCDRSFKNKASMKRHAKNKKSKSSIEEDPLLTGTENDAESSMIAESDGPSFIVTESDTSTSIVNETDGTTIIIAKDGLNSILPESIVPDCITPQTEAAASILPESIIPDFILKPKNEECIASENEAAAPVQSKNIAIPSTSREWKQYMKCPRCEKKFSTNLIRAHLRLCKEKKKPFFLLCSLCPFKTTKTGSFIEHVKITHGRTTEEHKYHKCPNCDRWVEYHIIDSIMEG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-