Basic Information

Gene Symbol
ZFX
Assembly
GCA_900474385.1
Location
UCOM01002449.1:16635-22435[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 1.9 1.8e+02 3.2 0.1 3 23 19 39 18 39 0.94
2 15 3 2.9e+02 2.6 3.3 1 19 1001 1019 1001 1024 0.75
3 15 0.85 83 4.3 4.0 2 23 1110 1132 1109 1132 0.94
4 15 0.001 0.1 13.4 0.4 2 23 1145 1166 1145 1166 0.98
5 15 1.7e-05 0.0017 19.1 3.1 2 23 1169 1190 1168 1190 0.97
6 15 0.009 0.88 10.5 0.3 1 23 1196 1218 1196 1218 0.95
7 15 2.8e-05 0.0027 18.4 4.5 2 23 1225 1246 1224 1247 0.95
8 15 0.12 12 6.9 3.7 5 23 1260 1278 1259 1278 0.97
9 15 2.5e-05 0.0024 18.5 1.5 3 23 1285 1306 1284 1306 0.97
10 15 0.011 1.1 10.2 0.3 2 23 1322 1342 1321 1342 0.97
11 15 7.5e-05 0.0073 17.0 0.7 1 20 1348 1367 1348 1370 0.92
12 15 9.3e-05 0.0091 16.7 2.7 1 23 1378 1400 1378 1400 0.99
13 15 0.0026 0.25 12.2 3.2 1 23 1406 1428 1406 1428 0.97
14 15 4.5e-06 0.00044 20.9 3.8 1 23 1434 1456 1434 1456 0.99
15 15 0.00034 0.033 15.0 7.2 1 23 1462 1484 1462 1485 0.96

Sequence Information

Coding Sequence
ATGGACCTCAGCTCGAGCATGAGTGCCCTGTCAGCAGGGACGGGGGCAGTGGCCTGTCCGGTCTGCACGCTGTATCTGCGCGAAGGCATCAGCTTGCAGAAACACTTGGACACGCATCCGAAGGAGCAGGTGATCGAGGCGTTGAtccgcgcgagcgccgccggTGGAGCCGCGGCTCTGCTCGGACAGGTAACGCAACCACagacgcagcagcagctgtCGCATCAGCCGGCGACGACCTCGGCAGTcgcggccgcgccgccgaCCCCGAGCCCCGGCGCCGCgcctcagcagcagcagccggcgaCACCTTCGCCCAGTACGCATGTTCCTCACGCCCAGTCGCCCTATCCGATTGGGCCTATCTTTGAGTGTCCGCCGATCAACGCCATGATTCCGCCACCACAGTTCGCATCCTTTAGCTATCAACAGTTTGTCAATAATGGTACAATGATGATACCTGCACAGTATGCGATGCAAGCCCAACCACCACAGACCAGTCAAATGATGCAGATGCTGTACAGTCCTTACGGTATGTACCATCAGCAACAGATTCCCACGGTCCAAATGATCTCGGCACCACCGATGATCCCATCAACGACATCAGCGTTACCAACGACGGTTCCGGCTGTGACGACACGTATGAGACCCGCAACTAGTAACAGCAACGTCTCCATCACAGCTGTGAGTGAAACAACGACTCCAACGACATCGCCGCCAAGATCGTCGCCTCCGACATGTTCGCAGCAGTCACCGCAAGCGCAACAGCAGCATCAAGATGAGATCATTACTGAATCTACGAGACACACGATCATTCAGGAAATAATACCAGGGCCAGATCGAATTTTGCCGGACTTGGAGACTCCTTCGACGCCTGAGCCAACGCAACCTGAAGGAGAGGACGACAACAGTATGCAGATTGAACAGCAAGAGAATGAGTCTCCTAACTCTTGCATGCGGGAAGAAGAATCACACATCGTCGAACAATGTCAGACggAGAATCCGCCAACGTTGATCAGTAATAATTCTGAAGACGAAAATGCCGATGATGACAAGACTGAAAGTATCCTTCCTGATATAGAAGATAATCAAGAAATTGAATCTTTGTTAGTTCGAAATACAAACAGGGTAGAGAAcgacaaaaataatgaaatacaaGTAGAAGAATCTGTTGAACAGTCAAAAACCTCGATTCAAAAAGAAAGCGCAGAAAAAGAGGTAGTAGAAATTGTTCAAAATACTAAAGTAGATAATCATAAAGAGTTGGCGGAAAAATCTCAAGATTTACAAATGGTCACGGAGATTGAACAACCCGAAAATCTTTCTGTTGATCTTCCTATTGAAAATAGCACTTATtctgaaaaatcaaaagtcgAACAATTAAGTCGGTTACTTGGAAATATAGAATCGAACTTTAGTGACGTAGATTTAACAGTTAACGAAAAAGTGGATAGTGTCGAGAAATCTTCAGATGAAACTCAAAAAGCCTTGTTGGaagaaattccaaaaaaaccAAGTGAAGAAGATGAAAACACAAATGCTTCATACCGTAAAACGACACCCGAACCAATCGAGTGTAAGATTATTGTTGCGCATGACGATACGGACGTGTCATCTGTTGCCTCTGAAGACTCAGTTCATTGCGATTTAGAAATCCAAAAGATTAATACCATTTCTTATCAATATAAGTATTCTCAATCCGCTCCCTCGAGTCCAATTACAAAGAAGAAGCTGCAACGTTCTTTATCGCGAATTTCTCTGCGTTCTGATTTTGATCGATCGAACGAAAACATGTACCCTTACCCGACAAACTTTAAGCCCGCCTCGCTTGCAAGTTTCCTCAAAGATAATTACAATGACGAGGATATGGAACTTGAGGAGACAGAACATGATGCTTATATGAAGCAAACTGGCGGCATGATTGTTGAACGTGTAAGATCACACATGTCCTTATCAACGGATGTCAGTGGAGTATCCGTGTTAAAAGCAAGACGTACTAAAGTAGCTGGTTCACCTGTGTCCCTACATTCTTCTTCATCTTATTGTCAAACACTTGAAGACGACGAAGAAGATGATTCGGATGCGGATAGCTGCATGAGTTATCGTATGCATGAGAAGGATGATGATGacgaagaggaagaagaagaagaagaagaagaagacgaagaagaagaagaagaagatttGTTAGATGAAAAGAGCGGTCATTTAgtgggaaataaaaaaaacaaaactgcaACCATTTTGGAAATAAAGACCATCTCAGAACAGCAACAACCGGCAGACTTCCGAACTCAAAATCTTATGATCGATCATTATTCGTCTGCTCAATTTCCAATTGATAATCGACCGTCTCAAATACCTCAACAGCAATCTTCAGAAGTATCAGTACACGAGACTTATCCATTGTCTAATAGTgaaatttcccaaaatttaatgaacataTCTGAATGCGTGGATCCAACGACGAGTACGGACTCAAAAAGTTATTCTAGTTCCAACAAGTCGGTAGTGCAGAAACCCTCAACAGaactattaaatataagtGAAGATGCGCACGCAGGACCTAtgaatgtttttgaatttgacGGTCTGCAAATACTTGTGCCCAGCACATTTATCAGCGAGTCATCGCAGAAAGCTGTAAGCGGAACAAGCCAACAATCTTTATCAAGCAGTGAGAACGGGGCTGGAAACGATGAAGAAGTAAAAAGTGTGAATATGAGAGCAGACGAAACAATGCCACCTAGAGGTGAATTGTCCGAACAGGAAAGTAATGGTTGTACAGAGCCCTCAGCTTGGCAGTTATATATGGGACAAGAATCTTCGCGTATGTCAACGTCTTACGATTTGATGGCACGTGAAAGTTGGGAAGAATCTGAAGGTTCGGATCACGAAGACAACAACGGTGGTCCTTTACTCGATAGCCGTTCACTCGCAACTCATTTCACATCGAGTCTTTTTCTCGACAGAGACCGTAAAACACCCACACGTCGCATCTTTAAATGTACTCACTGTTCAGAAGTATTTGACTGTCCAAAAGAGCGGCGTGTCCACAGCACGATGGTCCATAAAGAAGCTGGTCCTTCCAGTAGTAACGATAATATGGATCAACAAGAACTCAAGGATATAAAGTTGTTGGAAGGACGCGCTAACGTTTTCGAAGAAATCTTCGTTCCTAGTGGCCTCCATGTACAACCAACGTATCAACACCATCCACAGCCGCTGCTACACCAACTTCAGCCACCGCAACATTCGGGCTCGACGAAAGCCGAAGGAGACGTCAAAATAGACTCTCTGCATCATCTTTCAGCAGTGACTGAAGTCACATGTACCTTGTGCAATCAAATCTTTAGCTGTGATAAGTCCTTGCAAATTCATCATAGACGTATTCATGTATCTGATCCCGTAAAACGTATTcgtgaaaatgcaaaatgcCAGATTTGCAACGAGGAATTCACATCCGTAGCGAGCTTTAACCTGCATCTTAAAATTCATCCACTCGAGTGCAGTCAATGTGGCAAGTACTTTTATCGCAAGCAGAACTTTAAGCTCCACATGAAGCGGCACTTGGGAATAAAACCTTTTCCCTGTTCCATCTGTGACAAGGCTTTCCTTACTAAACAGAAGTTGGATGAACACACAAATGGTCATACCGGAAATGCCCCTGTCAAGTGCAATCTCTGTAACGAGACTTTTAGACGATATTCCAATCTAACGCAGCATAAGAATCGCCATCATCTAAACATCAAGAAAAAACTTAAAGATTACATCTGTCATTGCGGCGAGGTGTTCCacacgaaaaaaaagcttgCTTGGCATAAGGAGACACACGATGAGAAGCCTAAAGCTTGCACTTACTGCAACgagcgttttatacacatggCCAGCTTAACGCGGCACATGCGTCGAGCTCATAACAGACGTTTCGTACCGGACGCGCAACGAGAAAGCGAAAATGTCGAGTGCCCTATTTGTAAGTGTATCTATCTGAGATCATCGTTGGCAGTTCACATGCGCGTTCATAATGGCGAAAGGCCCTACGAGTGTCAAGTCTGCTCAAAGGCCTTTAGTACCAAATGGAATCTTCAACTGCACAAGTGGACACACGCTGCCCGGAGTACCAAACCGTTTAAGTGCAATCAATGTAGTGCCGCCTTCTACAGACATAGTGACTACACGGCACATATGAACTCCCATCGAAATGTGAGGCCGTACACCTGCAACTATTGTGGAGCCCAGTTTATTAGGAAATACAATTGCTTGCGACACGTAAAAGAACACGAAGAGAACAAACAGTATACTTGTGAAGTATGCAACAAGACCTTTCATAGGTCTTATTATCTTAAAGAGCACTTGCGCGTACATTCGGGTGCAAGACCTTACACTTGTCACATTTGTGGCAAGTCTAGTAGCACAAAGTCTAATCATAATAAGCATGTCAGAATTCATCATGCACGCGAGCCTGTAAATACAGAGAGTTAA
Protein Sequence
MDLSSSMSALSAGTGAVACPVCTLYLREGISLQKHLDTHPKEQVIEALIRASAAGGAAALLGQVTQPQTQQQLSHQPATTSAVAAAPPTPSPGAAPQQQQPATPSPSTHVPHAQSPYPIGPIFECPPINAMIPPPQFASFSYQQFVNNGTMMIPAQYAMQAQPPQTSQMMQMLYSPYGMYHQQQIPTVQMISAPPMIPSTTSALPTTVPAVTTRMRPATSNSNVSITAVSETTTPTTSPPRSSPPTCSQQSPQAQQQHQDEIITESTRHTIIQEIIPGPDRILPDLETPSTPEPTQPEGEDDNSMQIEQQENESPNSCMREEESHIVEQCQTENPPTLISNNSEDENADDDKTESILPDIEDNQEIESLLVRNTNRVENDKNNEIQVEESVEQSKTSIQKESAEKEVVEIVQNTKVDNHKELAEKSQDLQMVTEIEQPENLSVDLPIENSTYSEKSKVEQLSRLLGNIESNFSDVDLTVNEKVDSVEKSSDETQKALLEEIPKKPSEEDENTNASYRKTTPEPIECKIIVAHDDTDVSSVASEDSVHCDLEIQKINTISYQYKYSQSAPSSPITKKKLQRSLSRISLRSDFDRSNENMYPYPTNFKPASLASFLKDNYNDEDMELEETEHDAYMKQTGGMIVERVRSHMSLSTDVSGVSVLKARRTKVAGSPVSLHSSSSYCQTLEDDEEDDSDADSCMSYRMHEKDDDDEEEEEEEEEEDEEEEEEDLLDEKSGHLVGNKKNKTATILEIKTISEQQQPADFRTQNLMIDHYSSAQFPIDNRPSQIPQQQSSEVSVHETYPLSNSEISQNLMNISECVDPTTSTDSKSYSSSNKSVVQKPSTELLNISEDAHAGPMNVFEFDGLQILVPSTFISESSQKAVSGTSQQSLSSSENGAGNDEEVKSVNMRADETMPPRGELSEQESNGCTEPSAWQLYMGQESSRMSTSYDLMARESWEESEGSDHEDNNGGPLLDSRSLATHFTSSLFLDRDRKTPTRRIFKCTHCSEVFDCPKERRVHSTMVHKEAGPSSSNDNMDQQELKDIKLLEGRANVFEEIFVPSGLHVQPTYQHHPQPLLHQLQPPQHSGSTKAEGDVKIDSLHHLSAVTEVTCTLCNQIFSCDKSLQIHHRRIHVSDPVKRIRENAKCQICNEEFTSVASFNLHLKIHPLECSQCGKYFYRKQNFKLHMKRHLGIKPFPCSICDKAFLTKQKLDEHTNGHTGNAPVKCNLCNETFRRYSNLTQHKNRHHLNIKKKLKDYICHCGEVFHTKKKLAWHKETHDEKPKACTYCNERFIHMASLTRHMRRAHNRRFVPDAQRESENVECPICKCIYLRSSLAVHMRVHNGERPYECQVCSKAFSTKWNLQLHKWTHAARSTKPFKCNQCSAAFYRHSDYTAHMNSHRNVRPYTCNYCGAQFIRKYNCLRHVKEHEENKQYTCEVCNKTFHRSYYLKEHLRVHSGARPYTCHICGKSSSTKSNHNKHVRIHHAREPVNTES

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01113664;
90% Identity
iTF_01110388;
80% Identity
-