Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 2.4e-06 0.00039 22.3 2.7 1 23 195 217 195 217 0.97

2 6 2.1e-05 0.0034 19.3 5.1 1 23 223 245 223 245 0.99

3 6 0.00039 0.063 15.3 0.2 1 23 251 274 251 274 0.90

4 6 3.2e-07 5.2e-05 25.1 0.4 3 23 282 302 280 302 0.97

5 6 9.5e-07 0.00015 23.6 1.7 1 23 308 330 308 330 0.97

6 6 1.7e-05 0.0027 19.7 4.5 1 23 336 359 336 359 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	2.4e-06	0.00039	22.3	2.7	1	23	195	217	195	217	0.97
2	6	2.1e-05	0.0034	19.3	5.1	1	23	223	245	223	245	0.99
3	6	0.00039	0.063	15.3	0.2	1	23	251	274	251	274	0.90
4	6	3.2e-07	5.2e-05	25.1	0.4	3	23	282	302	280	302	0.97
5	6	9.5e-07	0.00015	23.6	1.7	1	23	308	330	308	330	0.97
6	6	1.7e-05	0.0027	19.7	4.5	1	23	336	359	336	359	0.93

Coding Sequence: ATGGCGTTCGAACAACAACAGATCCAATCGAACAATATACTTAATTACTATTTGATAtccaacaaaaaccacatttgCCGCTTGTGCTTGGAGCGGAGCACTAAATTGGCCCCCATTTTCGACCCCATAAAACCACCCCACTTTAGTATACAGATAATGGCGTGTGCAAACGTACAGATAGAACCAAACGACCCATTCCCGCCGagtatttgtcaaaaatgcatTTCGCGCCTCAATTTGGCCTACCAATTCAAGCTTCAATGCGAAGGTTCGGACGCCAAATTGAGGCAGTGCTATGAAAGTTTGGAGATGCAAAATAATGCTGAATTCACAGTGGAATACCCTGTGAAAAACGAGTCGCAACCGCTCGTTTCGGTGGTGCCAAATGAACCAGAGACTGATCCAAAAACCATTGATTACAGTTTAGTTGGTGTTTATTCACAGACAACAACCGATTTGCAACTAATCCAAGATCCAACCTATACCGATTATAAACTACCAATAGTGCCGTATGAACCGGAAAAAACCCTAAAAATCGAGGATCTCAAGCCGCCGGAGTTGACGAAAATAACGCCGAAAATCCACAATTGCGACACGTGcggcaaaattttcaaaaccaaacccAGCCTGGTGCATCATATACGAATACACACCGGCGAACGACCGTATTCCTGCAAAATGTGCTCTAAAAGTTTTATCAATGGCGGGCACCTGCATACTCACATGAAAACCCATACAGGAGAAAAAAACCATGTCTGCGCAGCTTGCAGCAAGGCTTTTACTACGGCGCAGCAACTTACCAAGCATGTTATTGCTATTCATACGTCGGAACGGCCGTATGGTTGTACTTATTGCCCTAAAAGGTTTGCCAATGCAAGTAACTTGACAACCCACTTGAAAATCCACACAGGAGAAAAAAACTTCCACTGTGAAGTTTGCGgcaaaatgttttcaactaaCGGTCAGTTGCAGCAACATTCCAAAGTGCATACAGGCGAGAAGGCGTTTCTATGCGAGTTTTGTGATAAAAGGTTTTCGCAGAAGGCCCATTTGACGCGTCATACTACTCGAACTCATAATCGTACTGAGTAG
Protein Sequence: MAFEQQQIQSNNILNYYLISNKNHICRLCLERSTKLAPIFDPIKPPHFSIQIMACANVQIEPNDPFPPSICQKCISRLNLAYQFKLQCEGSDAKLRQCYESLEMQNNAEFTVEYPVKNESQPLVSVVPNEPETDPKTIDYSLVGVYSQTTTDLQLIQDPTYTDYKLPIVPYEPEKTLKIEDLKPPELTKITPKIHNCDTCGKIFKTKPSLVHHIRIHTGERPYSCKMCSKSFINGGHLHTHMKTHTGEKNHVCAACSKAFTTAQQLTKHVIAIHTSERPYGCTYCPKRFANASNLTTHLKIHTGEKNFHCEVCGKMFSTNGQLQQHSKVHTGEKAFLCEFCDKRFSQKAHLTRHTTRTHNRTE

Sequence clustering based on sequence similarity using MMseqs2