Basic Information

Gene Symbol
zfh1
Assembly
GCA_964007375.1
Location
OZ023312.1:28316184-28317464[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.009 1.4 10.6 0.9 1 23 68 90 68 91 0.93
2 12 1.7e-07 2.8e-05 25.4 0.8 3 23 103 123 102 123 0.98
3 12 2.9e-06 0.00047 21.6 4.9 1 23 143 165 143 165 0.98
4 12 0.00016 0.026 16.1 5.5 3 23 172 192 170 192 0.97
5 12 0.034 5.5 8.7 0.1 1 23 197 220 197 220 0.92
6 12 5.1e-08 8.1e-06 27.1 0.6 1 23 228 250 228 250 0.99
7 12 0.0012 0.18 13.4 1.3 1 23 256 279 256 279 0.93
8 12 3.8e-05 0.0061 18.0 0.9 2 23 291 312 290 312 0.96
9 12 3.3e-06 0.00053 21.4 2.0 1 23 318 340 318 340 0.96
10 12 1.8e-08 2.9e-06 28.5 0.2 1 23 346 368 346 368 0.98
11 12 1.3e-07 2.1e-05 25.8 0.9 1 23 374 396 374 396 0.98
12 12 0.0002 0.032 15.8 2.0 1 21 402 422 402 423 0.96

Sequence Information

Coding Sequence
ATGGCGATGCTAGAGAAGCTCGATCTGATGAGGAAAACCGTCACGAAGCCCGTGCCGAAGAAGAGGAAACGTACAACGTCGAATTTCGGCCTCCCGGAGGCCATAGCCGTCGCGCCGAAAATGGAGAAGATGGTAATCGCGGAGATCAAGGAGGAATTCGTGGTGGACGACGAGGACGAGCAGGAGGATCTACCGTTGGCTTACAATTGCTCGAGCTGCGGCATATTCTTCGCCAATCAGGAGCTCATGGACAAGCACGAGTCCGAGCATCACAGCAGCAAGAAGAAACGTCAGCAGAAGAACGCGTGCAACCAGTGCGGTCGAGTTTTTCGCACGAGCGTCACGTTGCGCAAGCACATGAAGATACACACCGGTAGGAAGCGCAAGGTCCCCAAGAAGCAACAAAAACGTGAAATCAAGGACGAATACACGTGTGACGTGTGCAACAAGGTATTTCGCCACAAGAGCAATTATTACAAGCATCGCGCGCGTCATCGTGACGAAAATCTCGCGTGCAATCATTGCCCGAAGAAGTTTCGTCTCCATCGGGATCTCAAGAGGCACGAGAAGACCCACTTTTATCCGAGCTACGTGTGCAAAGAGTGCGATTACGAGACAACCCTGCTGACAGCCCTGAGCATACACGTTGGCAAGCAACACAGCAATCCGGCCGACGTGCCCTACAAGTGCAACGAGTGCGACAAATCCTTTCGACGTCCGATCGATCTTCAGGAACATTACAACGTTCATTCGGGCGAGAAACCGTTCGCTTGTCAACAGTGCGGCGAGGCTTTCAATCTCCGACGTCAGCTCACCGCGCACTGTCGACGCGCTCATCCCGAAATGAAACCCGACAAAGTCACGAGCACCACTTGCGACATTTGCGGCCGTGTACTCTCAACCAAGAGATCCCTCTCGCGTCACAAAGAGAGTCACAATCCCACGAAACTTTATCTCTGTGACTTTTGCGGCAAGAGCCTCAGCAGCGCCGAACATCTCAAGAAACACCGGCGCATTCATACCGGTGAAAAACCATACGTATGCGACATATGCGGCAAAGGCTTCACCGATTCCGAAAATTTGCGCCTACATCGACGCGTGCACACGGGCGAAAAGCCCTACAAGTGCGATCAATGCCCCAAGGCGTTCTCCCAACGTTCCACACTGACGATTCATCGCCGCGGGCACACCGGCGAGAGACCGTACGTTTGCAAGATTTGCCATCGCGGCTTCTCCTGCCAGGGCAATCTCACCGCTCATCAGAAATCCACTTGTGTCTGA
Protein Sequence
MAMLEKLDLMRKTVTKPVPKKRKRTTSNFGLPEAIAVAPKMEKMVIAEIKEEFVVDDEDEQEDLPLAYNCSSCGIFFANQELMDKHESEHHSSKKKRQQKNACNQCGRVFRTSVTLRKHMKIHTGRKRKVPKKQQKREIKDEYTCDVCNKVFRHKSNYYKHRARHRDENLACNHCPKKFRLHRDLKRHEKTHFYPSYVCKECDYETTLLTALSIHVGKQHSNPADVPYKCNECDKSFRRPIDLQEHYNVHSGEKPFACQQCGEAFNLRRQLTAHCRRAHPEMKPDKVTSTTCDICGRVLSTKRSLSRHKESHNPTKLYLCDFCGKSLSSAEHLKKHRRIHTGEKPYVCDICGKGFTDSENLRLHRRVHTGEKPYKCDQCPKAFSQRSTLTIHRRGHTGERPYVCKICHRGFSCQGNLTAHQKSTCV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

80% Identity
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