Basic Information

Insect: Onthophagus taurus
Gene Symbol: topi
Assembly: GCA_000648695.2
Location: NW:150276-154250[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 13 0.00054 0.041 14.0 1.2 3 21 158 176 156 177 0.94

2 13 1.3e-06 9.6e-05 22.3 1.5 1 23 202 224 202 224 0.97

3 13 0.0051 0.39 10.9 2.0 2 23 231 252 231 252 0.95

4 13 0.025 1.9 8.8 0.0 2 20 271 289 270 291 0.93

5 13 1.7e-05 0.0013 18.7 0.5 2 23 358 379 357 379 0.97

6 13 0.093 7.1 6.9 3.0 2 20 422 440 421 445 0.82

7 13 1.7 1.3e+02 3.0 0.0 1 23 556 579 556 579 0.91

8 13 0.0017 0.13 12.4 0.2 1 23 583 605 583 605 0.97

9 13 7.4e-06 0.00056 19.9 5.4 1 23 611 633 611 633 0.98

10 13 0.015 1.1 9.5 0.2 1 23 639 664 639 664 0.96

11 13 0.075 5.7 7.3 2.9 1 23 670 692 670 692 0.86

12 13 9.9e-06 0.00075 19.5 0.5 3 23 700 720 698 720 0.98

13 13 2.5e-06 0.00019 21.4 0.7 1 23 726 749 726 749 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	13	0.00054	0.041	14.0	1.2	3	21	158	176	156	177	0.94
2	13	1.3e-06	9.6e-05	22.3	1.5	1	23	202	224	202	224	0.97
3	13	0.0051	0.39	10.9	2.0	2	23	231	252	231	252	0.95
4	13	0.025	1.9	8.8	0.0	2	20	271	289	270	291	0.93
5	13	1.7e-05	0.0013	18.7	0.5	2	23	358	379	357	379	0.97
6	13	0.093	7.1	6.9	3.0	2	20	422	440	421	445	0.82
7	13	1.7	1.3e+02	3.0	0.0	1	23	556	579	556	579	0.91
8	13	0.0017	0.13	12.4	0.2	1	23	583	605	583	605	0.97
9	13	7.4e-06	0.00056	19.9	5.4	1	23	611	633	611	633	0.98
10	13	0.015	1.1	9.5	0.2	1	23	639	664	639	664	0.96
11	13	0.075	5.7	7.3	2.9	1	23	670	692	670	692	0.86
12	13	9.9e-06	0.00075	19.5	0.5	3	23	700	720	698	720	0.98
13	13	2.5e-06	0.00019	21.4	0.7	1	23	726	749	726	749	0.98

Sequence Information

Coding Sequence: ATGTACACGTATTTTACTGTTGAAGAAAAATcttttgatttatatatttctttgaaAGATCTCTATGAACCAGGAAGCATAGCAAATGTGATCGTTGAGCCCAATTCGGATCATCTAGTTGCATTGAAGATGAACGCAAGTgatttatcttttataaacGTTCATCAAATGGTCCCTGATACAACGGTGAGTACTCTAGAGTACGAAATCGACAATATGTCACAAGAATGCATCATGAAAACGCCGGTAAGTCCGGATGTATCACCGAATTCTCATTTTCAAAgtgaaaaattacattttaaactcCCAATGGTAAATGTTGATAATTCTTCGATAAGAGTGATTAAAATCGGAAGCTTGGATGAAAATGTACTATCCGAAACTGACTCAATGGATTGTAAACCTACAGTTAATTCTCAGCATAATCAGAAAAGGGAATCTAAGATACCTAATATTCCAACTATGATAGCTTGCCAGAATTGCGACACGAATTTCCCAACGAAATATCAATATCAAAGACACCAGTGCGAATTTAACGCTGAAAAAGTTGTCTTAAAACCGAATGTTGATATAAAAGATATCGATAAAGGGATGAGAATGAAATTTGATTGTTCAACGTGTGGAAAACAGTttgtaagtaaaaataatttagaacgTCATCAGACAAGTCATGatgaaacaaatattaatgtaTGTGAACATTGTAACAAACAGTTTGTTAGTGAGAATCGTTTAAGAATACATAAAGAAAATCATTGTAAAAAAGCAGGTGATATTTCAAAGTTTTATAGAAGCGATGTTACAGTTTGGAAATGCGAAAATTGTTATCAAGTTTTTGCCACACCAGCATCAGCTAATAAACACGTAGAAAATTGTGCAGAAAATTTACATATCAATAAAAACGGTGTCGATAAAACTGATGATGACAACGAAGATTGCAAAGCTTTAAAcgacgaaattaaaaatgtatcaacAGTAGCACCCGATTTATTAGAGCAAAGTGGTGGGTTTCAAGAAAAAGATACACCATCGAATAAAAACGTTCAAAAATTCTTAACCGAACAATTATTACAATGTGAATATTGCAACCGAACTTACGCCGATAAAAGATGGTTATTAGCTCACCAAAAACAACACACCACCGATGTTAATTACGAATGCATAACATGTTGCGAAACTTTTGATTCGTACGTTTTCGCTTCAAAGCATTGGTTAACAAAGTGTACGGACCAAGCGAATTTGTTCTATCTCCCAAAATTAACGTATTGCGAATATTGCGATCGTACATTTAAGTCACACGAAATTCTTTATAcccataaatataaaaagaaacattatACGCCAAAAGTTTACGTTTCGTTAACTAAAGATAAGAACAAAGAAGCAATCGTTAAATTAATCGAAGACGTATTGTTTTCGATGAACACCGAAGAAGAGGACAAAGAAAACGATGATGGTAATCAAAGTAGTAGTAACAAAGAAAATGGCGATGACAATAGcgatattgttattaaatcgGAAATATGCAGCGAATCGAGTGGATTCAGTAAATCGGATGGGAACGGTGgcgaaaatgaaaagaaacgACGCGGCCGGAAACGGAAATGTTCCAGgcaaataagtaaaaataaacgtttgaATGCTGTTGTTGATGATGGGTATAAATATCAATGTGAACGTTGCGTAACCGTTTGGAATAGTATTGCTGATTTGGAGAATCATAGAGAATTGGAACATCCCGCTAAGTTTAAATGTGAAGAATGTGGAcaagttgTTCATAGTGCAAAAGCTTTATTAATCCATAGTAGAGCTCATCAAAGTTTAAAACCGTACGTTTGTGAAATTTGTAAAAGATGTTATTCACAAACTTCCCATTTATGGCAACATATGAGATTTCATCAAgGTATAAAACCTTTTGCATGTCCCCACGAAGGTTGCGAAGCTCGTTATACGATCCGACCAGATTTAAAAGATCACATTAGAAAAGTCCACACCCGAGAACGTCCTTTTAAATGTTCCGTCTGTGATAAATGTTTCCTAACCGGTTCCGTTTATTATCAGCACCGTTTAATCCACACAAATGATCGTAGATATGGTTGTGatATTTGTCAAAAGCGATTCTTCCGAGCTGACGCACTCAACAATCATCGTAGAATTCACACCGATGAACGTCCGTATCCTTGTGATATTTGTGGGAGACAATTTCGACAAAAAGGTGATAGGAATAAACATGTTCGTACCCAACATCcgtcttaa
Protein Sequence: MYTYFTVEEKSFDLYISLKDLYEPGSIANVIVEPNSDHLVALKMNASDLSFINVHQMVPDTTVSTLEYEIDNMSQECIMKTPVSPDVSPNSHFQSEKLHFKLPMVNVDNSSIRVIKIGSLDENVLSETDSMDCKPTVNSQHNQKRESKIPNIPTMIACQNCDTNFPTKYQYQRHQCEFNAEKVVLKPNVDIKDIDKGMRMKFDCSTCGKQFVSKNNLERHQTSHDETNINVCEHCNKQFVSENRLRIHKENHCKKAGDISKFYRSDVTVWKCENCYQVFATPASANKHVENCAENLHINKNGVDKTDDDNEDCKALNDEIKNVSTVAPDLLEQSGGFQEKDTPSNKNVQKFLTEQLLQCEYCNRTYADKRWLLAHQKQHTTDVNYECITCCETFDSYVFASKHWLTKCTDQANLFYLPKLTYCEYCDRTFKSHEILYTHKYKKKHYTPKVYVSLTKDKNKEAIVKLIEDVLFSMNTEEEDKENDDGNQSSSNKENGDDNSDIVIKSEICSESSGFSKSDGNGGENEKKRRGRKRKCSRQISKNKRLNAVVDDGYKYQCERCVTVWNSIADLENHRELEHPAKFKCEECGQVVHSAKALLIHSRAHQSLKPYVCEICKRCYSQTSHLWQHMRFHQGIKPFACPHEGCEARYTIRPDLKDHIRKVHTRERPFKCSVCDKCFLTGSVYYQHRLIHTNDRRYGCDICQKRFFRADALNNHRRIHTDERPYPCDICGRQFRQKGDRNKHVRTQHPS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01097830;
90% Identity: iTF_01097830;
80% Identity: -