Otau003618.1
Basic Information
- Insect
- Onthophagus taurus
- Gene Symbol
- -
- Assembly
- GCA_000648695.2
- Location
- NW:19-5556[+]
Transcription Factor Domain
- TF Family
- HSF
- Domain
- HSF_DNA-bind domain
- PFAM
- PF00447
- TF Group
- Helix-turn-helix
- Description
- Heat shock factor (HSF) is a transcriptional activator of heat shock genes [1, 4]: it binds specifically to heat shock promoter elements, which are palindromic sequences rich with repetitive purine and pyrimidine motifs [1]. Under normal conditions, HSF is a homo-trimeric cytoplasmic protein, but heat shock activation results in relocalisation to the nucleus [2]. Each HSF monomer contains one C-terminal and three N-terminal leucine zipper repeats [3]. Point mutations in these regions result in disruption of cellular localisation, rendering the protein constitutively nuclear [2]. Two sequences flanking the N-terminal zippers fit the consensus of a bi- partite nuclear localisation signal (NLS). Interaction between the N- and C-terminal zippers may result in a structure that masks the NLS sequences: following activation of HSF, these may then be unmasked, resulting in relocalisation of the protein to the nucleus [3]. The DNA-binding component of HSF lies to the N terminus of the first NLS region, and is referred to as the HSF domain.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 10 0.28 1.9e+03 -0.9 0.0 8 27 21 40 16 42 0.80 2 10 0.02 1.4e+02 2.7 0.0 6 27 111 132 108 137 0.91 3 10 0.02 1.4e+02 2.7 0.0 6 27 203 224 200 229 0.91 4 10 0.02 1.4e+02 2.7 0.0 6 27 295 316 292 321 0.91 5 10 0.02 1.4e+02 2.7 0.0 6 27 387 408 384 413 0.91 6 10 0.016 1.1e+02 3.0 0.0 6 27 479 500 476 504 0.90 7 10 0.022 1.5e+02 2.6 0.0 6 27 572 593 569 598 0.91 8 10 0.18 1.3e+03 -0.4 0.0 7 27 666 686 661 689 0.81 9 10 0.024 1.7e+02 2.4 0.0 6 27 758 779 755 783 0.90 10 10 0.0082 56 4.0 0.0 6 27 851 872 848 876 0.90
Sequence Information
- Coding Sequence
- ATGATAATTGGTTATTTAGTACCACCAACTCAAGATGCCGTAAATTACATAACAATGACAATTGAACAAGACGGACAAAATAGCAAATTTGTGACGTGGACTGATTATGGTGCTGAATTCAAAGGATGTGAGGTAACGTACAGTCTAACTGTAAATGATAGTCCGATAGAAACGGAATTAACCACCAACACCTACATCTTTACCAATGAACTGACGGAAACCTGCAAGAACATGGTTAAAGTGGTGGCAACAGTTTCGGGAGTTATTGGAACCCCCGGAGATATCTCCATAGTAGTACCACCAACTCAAGATGCCGTAAATGACATAACAATGACAATTGTGCAAGACGGAGAAAACAGCAAATTTGTGACATGGACTGATTATGGCACTGAATTCGAAGGATGTGAGGTAACGTACAGTCTAACTGTAAACGGCATTCCGATAGAAACGGAATTAACCACCAACACCTACACCTTTACCAATGAACTGACGGAAACCTGCAAGAACATGGTTAAAGTGGTGGCATCAGTCTCGGGAGTTTTTGGAACAGCCGGAGATATCTCCATTGTAGTACCACCAACTCAAGATGCCGTAAATGACATAACAATGACAATTGTGCAAGACGGAGAAAACAGCAAATTTGTGACATGGACTGATTATGGCACTGAATTCGAAGGATGTGAGGTAACGTACAGTCTAACTGTAAACGGCATTCCGATAGAAACGGAATTAACCACCAACACCTACACCTTTACCAATGAACTGACGGAAACCTGCAAGAACATGGTTAAAGTGGTGGCATCAGTCTCGGGAGTTTTTGGAACAGCCGGAGATATCTCCATTGTAGTACCACCAACTCAAGATGCCGTAAATGACATAACAATGACAATTGTGCAAGACGGAGAAAACAGCAAATTTGTGACATGGACTGATTATGGCACTGAATTCGAAGGATGTGAGGTAACGTACAGTCTAACTGTAAACGGCATTCCGATAGAAACGGAATTAACCACCAACACCTACACCTTTACCAATGAACTGACGGAAACCTGCAAGAACATGGTTAAAGTGGTGGCATCAGTCTCGGGAGTTTTTGGAACAGCCGGAGATATCTCCATTGTAGTACCACCAACTCAAGATGCCGTAAATGACATAACAATGACAATTGTGCAAGACGGAGAAAACAGCAAATTTGTGACATGGACTGATTATGGCACTGAATTCGAAGGATGTGAGGTAACGTACAGTCTAACTGTAAACGGCATTCCGATAGAAACGGAATTAACCACCAACACCTACACCTTTACCAATGAACTGACGGAAACCTGCAAGAACATGGTTAAAGTGGTGGCATCAGTCTCGGGAGTTTTTGGAACAGCCGGAGATATCTCCATTGTAGTACCACCAACTCAAGATGCCGTAAATGACATAACAATGACAATTGTGCAAGACGGACAAAATAGCAAAATTGTGACGTGGACTGATTATGGCACTGAATTCGAAGGATGTGAGGTAACGTACAGTCTAACCGTAAACGACAGTCCGATAGAAACGGAATTAACCACCAACACCTACACCTTTACCAACGAACTGACGGAAAACTGCAAGAGCAATAAGGTGGAAGTGGTGGCATCAGTCTCGGGAGTTATTGGAACACCCGGAGATATCTCTATAGTAGTACCACCAATTCAGGATGCCGTAAATGACATAACAATGACAATTGTGCAAGATGGAGAAAACAGCAAATTTGTGACATGGACTGATTATGGTACTGAATTCGATGAATGTGAGGTAACGTACAGTCTAAGTGTAAACGGCATTCCGATAGAAACAGAATTAACCACCAACACCTACACCTTTACCAACGAACTGACGGAAAACTGCAAAAGCAATAAGGTGGAAGTGGTGGCATCAGTCTCGGGAGTTATTGGAATACCCGGAGATATCTCCATAGTAGTACCACCAACTCAAGATGCCGTAAATGACATAACAATGACAATTGAGCAAGACGACCAAGATAGTAAAATTGTGACGTGGACTAATTATGGTACTGAATTCGAAGGATGTCAGGTAACGTACAGTCTAACCGTAAACGACAGTCCGATAGAAACGGAATTAACCATCAACACCTACACCTTTACCAACGAACTGACGGAAAACTGCAAGAGCAATAAGGTGGAAGTGGTGGCATCAGTCTCGGGAGTTATTGGAATCCCCGGAGATATCTCCATAGCAGTACCACTAACTCAAGATGCCGTAAATGACATAACAATGACAATTGTACAAGATGGACAAAATAGCAAACTTGTGACGTGGACTGATTATGGTACTGAATTCGAAGGGTGTGAGGTAACGTACAGTCTAACTGTAAACGACATTCCGATAGACAGGGAATTAACCATCAACACCTACACCTTTACCAACGAACTGACGGAAAACTGCAAGAGCAATAAGGTGGAAGTGGTGGCATCAGTCTCGGGAGTTATTGGAACCCCCGGAGATATCTCCATAGTAGTACCACCAACTCAAGATGCCGTAAATGACATAACAATGGCAATTGTGCAAGACGACCAAAATAGTAAAATTGTGACGTGGACTGATTATGGCACTGAATTCGAAGGGTGTGAGGTAACGTACAGTCTAACTGTAAACGACATTCCGATAGACAGGGAATTAACCATCAACACCTACACTTTTACCAACGAACTGACGGAAAACTGCAAGAGCAATAAGGTCGAAGTGGTGGCATCAGTCTCGGGAGTTATTGGAACCCCCGGAGATATCTCCATAGTATTACCACCAACTCAAGATGCCGTAAATGACATAACAATGACAATTGAGCAAGACGACCAAGATAGTAAAATTGATAACCACCAACACCTACACCTTTACCAATGA
- Protein Sequence
- MIIGYLVPPTQDAVNYITMTIEQDGQNSKFVTWTDYGAEFKGCEVTYSLTVNDSPIETELTTNTYIFTNELTETCKNMVKVVATVSGVIGTPGDISIVVPPTQDAVNDITMTIVQDGENSKFVTWTDYGTEFEGCEVTYSLTVNGIPIETELTTNTYTFTNELTETCKNMVKVVASVSGVFGTAGDISIVVPPTQDAVNDITMTIVQDGENSKFVTWTDYGTEFEGCEVTYSLTVNGIPIETELTTNTYTFTNELTETCKNMVKVVASVSGVFGTAGDISIVVPPTQDAVNDITMTIVQDGENSKFVTWTDYGTEFEGCEVTYSLTVNGIPIETELTTNTYTFTNELTETCKNMVKVVASVSGVFGTAGDISIVVPPTQDAVNDITMTIVQDGENSKFVTWTDYGTEFEGCEVTYSLTVNGIPIETELTTNTYTFTNELTETCKNMVKVVASVSGVFGTAGDISIVVPPTQDAVNDITMTIVQDGQNSKIVTWTDYGTEFEGCEVTYSLTVNDSPIETELTTNTYTFTNELTENCKSNKVEVVASVSGVIGTPGDISIVVPPIQDAVNDITMTIVQDGENSKFVTWTDYGTEFDECEVTYSLSVNGIPIETELTTNTYTFTNELTENCKSNKVEVVASVSGVIGIPGDISIVVPPTQDAVNDITMTIEQDDQDSKIVTWTNYGTEFEGCQVTYSLTVNDSPIETELTINTYTFTNELTENCKSNKVEVVASVSGVIGIPGDISIAVPLTQDAVNDITMTIVQDGQNSKLVTWTDYGTEFEGCEVTYSLTVNDIPIDRELTINTYTFTNELTENCKSNKVEVVASVSGVIGTPGDISIVVPPTQDAVNDITMAIVQDDQNSKIVTWTDYGTEFEGCEVTYSLTVNDIPIDRELTINTYTFTNELTENCKSNKVEVVASVSGVIGTPGDISIVLPPTQDAVNDITMTIEQDDQDSKIDNHQHLHLYQ
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -