Basic Information

Gene Symbol
ZEB2
Assembly
GCA_949316235.1
Location
OX438750.1:10163159-10168913[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 0.38 35 6.0 5.0 2 21 165 184 164 185 0.91
2 18 0.00031 0.029 15.7 1.5 1 23 218 241 218 241 0.95
3 18 0.00059 0.055 14.8 1.3 1 23 246 268 246 268 0.97
4 18 0.32 30 6.3 4.3 3 21 273 291 272 292 0.93
5 18 0.0028 0.26 12.7 2.1 2 23 336 358 335 358 0.95
6 18 0.073 6.9 8.3 0.3 2 23 365 385 364 385 0.95
7 18 0.3 28 6.3 1.6 1 23 391 413 391 413 0.90
8 18 0.0042 0.39 12.2 2.5 1 23 419 442 419 442 0.98
9 18 0.0051 0.48 11.9 0.3 1 23 452 475 452 475 0.94
10 18 0.006 0.55 11.7 3.3 1 23 486 508 486 508 0.98
11 18 0.001 0.093 14.1 0.1 2 21 635 654 634 655 0.94
12 18 0.0025 0.24 12.9 0.3 1 23 686 709 686 709 0.97
13 18 0.0016 0.15 13.5 0.8 3 23 716 736 715 736 0.97
14 18 1.9 1.8e+02 3.8 2.8 1 20 739 757 739 759 0.90
15 18 0.23 21 6.7 2.0 1 23 770 793 770 793 0.88
16 18 0.02 1.9 10.0 2.2 1 19 799 817 799 821 0.87
17 18 0.59 55 5.4 5.9 1 23 828 850 828 850 0.95
18 18 5.3e-06 0.0005 21.3 2.5 1 23 866 888 866 888 0.98

Sequence Information

Coding Sequence
ATGAGTCGACAAGTGGACGTAAAAGCATTAGTTTCGCATATAGTGCGTGGAGATGGGGCAGACAAATGCCGAATATGCATGGGCGACACATCAGAGGGTCAGGTTTACCTTGGAGATACCGTTATGAAGGACGGCGACAAGCCCGTGACCCTGGCTGAGCTATTGGAAATCATCACGGGAGTCGAGGTACCGCTGGATGATGACCTGCCACTGGGGCTTTGTGCGGTGTGCACAGCCTCCGCGATGGCAGCGGCCACTTTCCGCAGCCTCTGCCAACGAGCAGTCAATCACTGGAAGTCAACGGTGCATCTTCTAGAAAGCCTACCGTACTCCACAGAATATGCACATAAAAAAGCTATTTATGCAATTCTAAACGGCAATGAAATTACTATTATAGATCATGACTATGACAGtcatgatgatgattttgaatcgGATTCCATAGAGCAACCAAGGAAAACAAGGCGGACTAAAATTGTTAAACAAAAGTGCCAATGCCCTGACTGTGATAAGGAGTTCATTTGTCACCAGCATTTATACCAACACTTAATGGATTCAACAGACTATAAGCGATCATGTTATATTTGCGCGGCAATCATGACTAGAGATGaattacttaaacatatacctgCAGTACATGGTCAAAGTTTATATGACTGCAAGAAGTGTCCAGCTCTATTTAGCTCCCAGCAACATTTGAATCGGCATTTAGATAAAGCCCATGCTTCAGGAGCGTATTCATGTGGAGATTGTGGACGAAGCTTTCAGTCCTCGCATGCTTTTTATGGTCATTTATCAATGCACTCTGCCAAAAATTGTCCAGGTTGTGATAAATTGTTCCGTAACCACAGGTGTTACTTGCACCATGTAAAACAATGCTGCAATTTGGATGTGACTAGAGATGACACGTATCATactaaaaataaagtattattcgAAGTGAAGAGTAACAAAACTGAGAAGAAGATCAAAGTTGGTGTTCGTGGTAGCGCTGACTCGGAATGCATATGCGATTACTGCGGCAAAAAATTTGCTGGCAAAAAGTTTGTGTGCGCTCACATCCAAATAGTTCATATGAAGAACACACACAAACCTTGCCCATACTGCGGGAAACAGTTGGCTGCCGCACACATGAATGTCCATATAAAGAAACATGAGGTAGTCAGCTCTTTCACCTGTGAACACTGCGGGATTGTACTCAAAACTAAACTAGGTCACATCCAGCATGTACGTCTTCACACTGGAGAACGTCCATACAAATGCAAATATTGTTCGGAAACTTTCTCAGCATCATCCAGACGCTCTGAGCATATCCGTAAAACTCACAAGAGTGCGGATCAATTAGTTTTGAAGTATTCATGTGAGTTATGTCCGGCACGGTTTCGTTTGCCGTATAGATTGAAGAAACATGTGTCGAATGTGCATGTACAGACAAAAGACAACACGAACTTGACGTTTCAATGTACGGTTTGTCATGTAGAGTTTGGCACACGTCGTGGATTGCTACATCATGGTAGGAAGCACCAAACGCCATCCGATGCTAAAGAAAAATGGGTGGAGTCATCAGCACAGCTGCCACAAAAGGTGTGCAGCCGCTGCTTCGCCAACCTGACGGATGCCTTACCCTTCTTCGTTCTCTCCCGACAATCCGCGCGCTTGTGGCAGAATATCACCGATCATCTCCACGATTCCCCTCCACCAGACAACACTATGAATTTATACTTCGTTATGGACGGCGAGGAGCTGTATACCGTTGCCGATTCCGTAAACAGTAGAATTCCAAAGGCAACAAACAAGACACAGGCGTTGCGTAACTTCAAAACCAGATTGAATCGTGTGCGAGCTTACAAGAAACGCAGCCATAAAGAAACACGTGAGACGAAAGCTATCCAGTCTGGATTGCAATGCCCCGAATGTGACACGACGTTCAACGAAGTCACTCAACTTAATATCCACATAAAATATCTCGGCATCCGACGCTGCTACCACTGCCGTGAAGTCATGGAGATTAAGAATGTTAAGGAGCATCTGCGGACCGGGCACAACATCGAGTCATTTTCCTGCGAAATATGTTCAGATACTTACGAAAAAGAGAGTGGATTAATTAGACACATGAACAGGAATCACCGCAGAGGTTCAGCCTTCTGCGTATACTGCAAGATGTCGTTTCCAAACCAGCAAAGTTTGGTCAGTCACAGTCGGATGCACAAGACGCATATATGTACTGGTTGCGAGCGGAAATTCGCGAAAACCTGCTTTAAGAGACACATTGAAAATTGCTTTAACGCGCAAACTAGGCCCTCCCTCTTCATTTGCGATTACTGCAAGAAGGAATACAAGTTGAAGAACGCACTGAAATGTCACATCGTCAACGTACATCTAGTTGGGCCGAAGTTCCAATGTCACGAGTGCGGTAAAAAGTTTCTACACCGAATTGCTTTAGAGGAACACGATAATAGTCATAACAGGATCGAGGATCGTTACGTCTGTAGCGTGTGCGGCAATAAATATAGCTCTAGGAATGGATACCATCGGCATTGCAAACGTCATTTGGATGACGGGTCATTTGCACCGGATTTGAGACCTAAGAAAACCTATGCTTGCACCTTGTGTGAGAGGACGTTCAGTCGTAAGAGATACCTTACGGAGCATCAAAAAACTCATCCCTTCATACCGTTTGGACCCTCGGCCAGTGACATTAGCAGTACCGCTGTTGATTCTGGTTACAAAATACAGTATAAAGGCGTTAAGAacataatattcatataa
Protein Sequence
MSRQVDVKALVSHIVRGDGADKCRICMGDTSEGQVYLGDTVMKDGDKPVTLAELLEIITGVEVPLDDDLPLGLCAVCTASAMAAATFRSLCQRAVNHWKSTVHLLESLPYSTEYAHKKAIYAILNGNEITIIDHDYDSHDDDFESDSIEQPRKTRRTKIVKQKCQCPDCDKEFICHQHLYQHLMDSTDYKRSCYICAAIMTRDELLKHIPAVHGQSLYDCKKCPALFSSQQHLNRHLDKAHASGAYSCGDCGRSFQSSHAFYGHLSMHSAKNCPGCDKLFRNHRCYLHHVKQCCNLDVTRDDTYHTKNKVLFEVKSNKTEKKIKVGVRGSADSECICDYCGKKFAGKKFVCAHIQIVHMKNTHKPCPYCGKQLAAAHMNVHIKKHEVVSSFTCEHCGIVLKTKLGHIQHVRLHTGERPYKCKYCSETFSASSRRSEHIRKTHKSADQLVLKYSCELCPARFRLPYRLKKHVSNVHVQTKDNTNLTFQCTVCHVEFGTRRGLLHHGRKHQTPSDAKEKWVESSAQLPQKVCSRCFANLTDALPFFVLSRQSARLWQNITDHLHDSPPPDNTMNLYFVMDGEELYTVADSVNSRIPKATNKTQALRNFKTRLNRVRAYKKRSHKETRETKAIQSGLQCPECDTTFNEVTQLNIHIKYLGIRRCYHCREVMEIKNVKEHLRTGHNIESFSCEICSDTYEKESGLIRHMNRNHRRGSAFCVYCKMSFPNQQSLVSHSRMHKTHICTGCERKFAKTCFKRHIENCFNAQTRPSLFICDYCKKEYKLKNALKCHIVNVHLVGPKFQCHECGKKFLHRIALEEHDNSHNRIEDRYVCSVCGNKYSSRNGYHRHCKRHLDDGSFAPDLRPKKTYACTLCERTFSRKRYLTEHQKTHPFIPFGPSASDISSTAVDSGYKIQYKGVKNIIFI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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