Basic Information

Gene Symbol
-
Assembly
GCA_949825065.1
Location
OX463865.1:14801127-14805940[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 2.1e-05 0.0017 19.7 7.1 1 23 9 31 9 31 0.98
2 9 3.7e-06 0.00029 22.1 0.9 1 23 37 59 37 59 0.97
3 9 1e-06 8e-05 23.9 2.2 1 23 65 87 65 87 0.99
4 9 4.1e-05 0.0032 18.8 0.8 1 23 93 115 93 115 0.98
5 9 0.17 13 7.5 2.2 1 12 121 132 121 135 0.89
6 9 1.8 1.4e+02 4.2 0.8 11 23 154 166 154 166 0.92
7 9 2.5e-06 0.00019 22.6 0.6 1 23 172 194 172 194 0.98
8 9 0.0046 0.36 12.4 5.3 1 22 200 221 200 224 0.90
9 9 1.1e-05 0.00084 20.6 1.1 1 23 253 277 253 277 0.92

Sequence Information

Coding Sequence
ATGAAGCTGCACGAGAACAAGGTTCACAAGTGTCACTATTGCGGCAAGTGTATGACCACTTCCTACAGCCTCATCGCTCACATCCGAAGACATGAAGgcatAAAACCATTTGTGTGTGAGATTTGCAACAAAGCCTTTGTGGACAAGGGCAAGCTGTCACGGCACGTACACTCGCACAAGGGCACGCGTGACTTCCAGTGCGATATCTGCGAGAAGAGCTTCTCCGAGAGCCAGTATCTACGGCAGCATAAGAGAACACACGATCACAGCAGAGAGTATCCATGTCGTGTTTGTGGCACCAAATTCAAGAGTATGAACTCCGTGTGGTCCCACATGAGGAAGCACACGCACACCAATCGATACGAGTGCCAGTACTGCGGCAAGACATGTTACAGGATAGTTCAATCTATGGCATCTAGACCTTACGGAGTGGACAGATTGTATTATGTAGTAAATGATTCCAGACCTGACCACCTACGCTCGCATCTCATCTCGCACACGGGTATCAAGGAGTTCCAGTGTGAGATCTGCAGCAAGCGCTTTGCCAAGGCTTATGATCTCACGGAGCACCGAAGAGGACACAGCGGAGAACGCCCGTACCATTGTCGTCTCTGCAACAGGGCTTTTGCGAGGCACGGTGAATTCAGGaaACACAGAATGAGCAAGTATCATCGTGAACGAGAAATTGAAGCCGGTCTAACACCCTCCTTCCCACCCGCACAGTCAGAGCCTGGGACTGGCCGCCCGTCCGCATCACATCACTGTCCCGTGTGCGACAAGCGCTTCTCCACAGCACCAGGTCTAGCTGCGCATCTAAGGAGAAAATCACATCTTGCCAAAACAGGGCGAACACCGGATACTACGTTAGAAGAAGATCCTGGGCCAACAGAGAATGAAACAGAAATTGGAACTTAA
Protein Sequence
MKLHENKVHKCHYCGKCMTTSYSLIAHIRRHEGIKPFVCEICNKAFVDKGKLSRHVHSHKGTRDFQCDICEKSFSESQYLRQHKRTHDHSREYPCRVCGTKFKSMNSVWSHMRKHTHTNRYECQYCGKTCYRIVQSMASRPYGVDRLYYVVNDSRPDHLRSHLISHTGIKEFQCEICSKRFAKAYDLTEHRRGHSGERPYHCRLCNRAFARHGEFRKHRMSKYHREREIEAGLTPSFPPAQSEPGTGRPSASHHCPVCDKRFSTAPGLAAHLRRKSHLAKTGRTPDTTLEEDPGPTENETEIGT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-