Basic Information

Transcription Factor Domain

TF Family: AP-2
Domain: TF_AP-2 domain
PFAM: PF03299
TF Group: Basic Domians group
Description: Activator protein-2 (AP-2) transcription factors constitute a family of closely related and evolutionarily conserved proteins that bind to the DNA consensus sequence GCCNNNGGC and stimulate target gene transcription [PMID: 2010091, PMID: 1998122]. Four different isoforms of AP-2 have been identified in mammals, termed AP-2 alpha, beta, gamma and delta. Each family member shares a common structure, possessing a proline/glutamine-rich domain in the N-terminal region, which is responsible for transcriptional activation [PMID: 2010091], and a helix-span-helix domain in the C-terminal region, which mediates dimerisation and site-specific DNA binding [PMID: 199812]. http://www.ebi.ac.uk/interpro/entry/IPR013854
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 0.00047 8.6 7.2 0.0 101 156 13 65 5 77 0.75

2 3 0.00045 8.3 7.2 0.1 90 154 93 154 88 168 0.79

3 3 0.00064 12 6.7 0.0 93 154 187 245 181 259 0.77

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	0.00047	8.6	7.2	0.0	101	156	13	65	5	77	0.75
2	3	0.00045	8.3	7.2	0.1	90	154	93	154	88	168	0.79
3	3	0.00064	12	6.7	0.0	93	154	187	245	181	259	0.77

Coding Sequence: ATGATTTTCGTTCTTTTCGCCCTCGTGGCCACCACCTATGCCAACAGGTACCCCATTGCCCAGGAGATGGTCAACAAGGGCATCATTGATGATGCTCTGGCCATCAAGGAATGCCTGGAAAAGGCCATCGCCAATATCCAgCAAAGCTTGAATAACCTGCTCGGCAGCGTGAGCCTCATCACCGGACTCGTCAACAGTTACGTCGAAAAGCTCAATGCTTGCATGTCCCTTGGTCCCATCCAGTCAGCCGCCTGCATCTTGAATCTGGTGGACGCTCTTAAGGCGGATGTCAACAACACCATTGCCATGTATGCTTACAGTAGCCCCATTGCCCAGGAGATGGCCAATAAGAACATTATTGATGATGCTCTGGCCATCAAAGAGTGTCTGGAAAGGGCCATCGCCAATATCCagCAAAGCTTGAATAACCTGCTCGGCAGCGTGAACCTCATCAACGGACTCGTCAACAGTTACGTCGAAAAGCTGAATGCTTGCATGTCCCTTGGTCCCATCCAGCAAGCCGCCTGCATCCTGAATCTGGTGGATGCTATTAAGGCCGATGTCAACAACACCATTGCCATGTATGCCAACAGGTACCCCATTGCCCAGGAAATGGTCAACAAAGGCATCATTGATGATGCTCTGGCCATCAAGGAATGCCTTGAAAAGGCCATCGCCAATATCCAgcaaAGCTTGAATAACCTGCTCGGCAGCGTGAGCCTCATCAACGGACTTGTCAACAGTTACGTCGAAAAGTTGAATGCTTGCATGTCCCTTGGTCCCATCCAGCAAGCCGCCTGCATCCTGAATCTGGTGGATGCTATTAAGGTCGATGTCAACAACACCATTGCCATGcTCCAACAGAGTTTGAATGACCTCCTCAACGCTGGAAACACAGTGACAGCTTGCTTCGCTTAA
Protein Sequence: MIFVLFALVATTYANRYPIAQEMVNKGIIDDALAIKECLEKAIANIQQSLNNLLGSVSLITGLVNSYVEKLNACMSLGPIQSAACILNLVDALKADVNNTIAMYAYSSPIAQEMANKNIIDDALAIKECLERAIANIQQSLNNLLGSVNLINGLVNSYVEKLNACMSLGPIQQAACILNLVDAIKADVNNTIAMYANRYPIAQEMVNKGIIDDALAIKECLEKAIANIQQSLNNLLGSVSLINGLVNSYVEKLNACMSLGPIQQAACILNLVDAIKVDVNNTIAMLQQSLNDLLNAGNTVTACFA

Sequence clustering based on sequence similarity using MMseqs2