Basic Information

Gene Symbol
prg
Assembly
GCA_958449745.1
Location
OY288203.1:7498827-7500663[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.36 29 6.1 3.5 1 20 178 197 178 201 0.83
2 10 0.0096 0.77 11.0 0.4 1 23 207 230 207 230 0.96
3 10 3.8e-06 0.0003 21.8 3.6 1 23 236 258 236 258 0.96
4 10 3e-07 2.4e-05 25.2 2.8 1 23 264 286 264 286 0.99
5 10 2e-05 0.0016 19.5 0.1 1 23 292 314 292 314 0.97
6 10 0.0011 0.091 14.0 3.1 1 23 320 342 320 342 0.97
7 10 6.8e-05 0.0054 17.8 1.5 2 23 443 465 442 465 0.95
8 10 6.2e-05 0.005 17.9 1.1 1 23 471 493 471 493 0.95
9 10 3.5e-05 0.0028 18.7 3.3 1 23 499 521 499 521 0.98
10 10 0.0039 0.32 12.3 0.0 3 23 530 550 528 550 0.92

Sequence Information

Coding Sequence
ATGGAAGATTCCTACATTATCGCCaatttccacacactgtgtcgaCTGTGTCTGCACAAAAGCACATTCTCAACATCGTTATTCGCAGCTACGCCAGACGACGAAACAAATGTTGCTTTAACCTCTAAACTAGCTGAATGTTTCGAGTTGCAGATTGATCCTAATGATGGGCTGCCTAATAGAATCTGCTACAAATGCTTGTTCAAAGTTGATAAATGCACAAAATTCAAGCTACAGTGCATTCAAAATGAGAACAGGTTAAGACAAATCACAATAAGAGCTAATGAACTGGACAACTCAAATTCATCAGAGCTCAGCAACTACAACTATGGTTCACATCCTCTAGAtgaagtgaaacctaaacctgAGGAGTACATTGTTGAAGATAGTGTTGTGATGGTGGTTGATCCCAGCCTTGACTATGACTCTTCTGAGGAGTCTGAAAATATGGAGCCTGTTGAACCAGAAGTAATTGAAAGAAACAACACACCAGATGGTGAACCAATGACTGAATCCTTTTTCAAAAATGTGTTCATGTGTCAATACTGTGACCAAGCATTTGTTTCACAAGAAAAATGTAAGGAACATGAACATGCTTACCATGATCCCAACTTACCATATAAATGTGTTGAGTGTAGTCTAGTCTTTGCTGAGCGAAATCAATATGTGCAGCACACTAAACAAGTTCATGGCAATGATAAACCCTACCACTGTCCAGAATGTGATAAGTGCTTTGGGAGACGCTCTGATTTGAGAAAGCACTCCATTGTCCACACTGGCATAAGGCCATATCAATGTCAATATTGCTTGAAAAGCTTCTCCCGCAATACTAATCTTAGCAAACATCTGCGAATACATGCTGGACACAAACCTCATGTGTGCCCTCTTTGTCCAAGGAGCTTTGTGGCAAAAGGAGACTTACAACGACATGTGCTTGTTCATTCAGGGATGAAGCCTTTTGCATGTCGAAAATGCCACTTAACATTTGGTAGAAGAGATAAACTTATAAAACATGAAATGCGACACACTGCTATGAGCCCAGGCAAAACAAATGCACATTCCTTTGTTTTGCCTAACCAAGATCAAGATACCCATGATATGGTGGTAAATGTAAACCCCTTTAGCAATCTTATGACTTCTCCTACCCAGCTACATCCTGATTCATCAAATACTGATTTTGATCTACCCAGAGTCCCAGATCACATCTCGGGAGAGAGCAGTTTTATGAAAGTACAGAAAAATACTTCTGCTACAAATAAGCCTATTCACCATTCCCCACCAAAACAGAAAGCTGCAGCAGCAAATAAAAACAGGCCAAAGAATATTAAATGTCATCAGTGCCCTAAAAGGTTTAGCTCTTTAGATTCCTACAAAACACATGTGTCTATTGCACATATTGGATCCAGGGTCTTCCAGTGCaagatttgttttaaaaagttccCCCGCAAGAGAGAGTTGGACCGTCATGCAGCTCTCCATTCTGGTATGAAACCATTTTCATGCAGTCAATGTGATAAAAAGTTTACTAAGAAGGACAAACTTGATAAACATGAGCAAACTCATGAATGCCTGGTTGTGAATATGCCTTGCATAGAATGTGGTGCCACCTTTGAGAAGAAACCTGATTTAGTTGCACATATAAAATCACACTTTACTGAAAATTTTGATGACAAAATAGCTGAAGCTGTAATTAAGAAAGAAGAGGAAACTGAATTTAATTTGGATGACAATTTCTATGACTTGGAAACATGA
Protein Sequence
MEDSYIIANFHTLCRLCLHKSTFSTSLFAATPDDETNVALTSKLAECFELQIDPNDGLPNRICYKCLFKVDKCTKFKLQCIQNENRLRQITIRANELDNSNSSELSNYNYGSHPLDEVKPKPEEYIVEDSVVMVVDPSLDYDSSEESENMEPVEPEVIERNNTPDGEPMTESFFKNVFMCQYCDQAFVSQEKCKEHEHAYHDPNLPYKCVECSLVFAERNQYVQHTKQVHGNDKPYHCPECDKCFGRRSDLRKHSIVHTGIRPYQCQYCLKSFSRNTNLSKHLRIHAGHKPHVCPLCPRSFVAKGDLQRHVLVHSGMKPFACRKCHLTFGRRDKLIKHEMRHTAMSPGKTNAHSFVLPNQDQDTHDMVVNVNPFSNLMTSPTQLHPDSSNTDFDLPRVPDHISGESSFMKVQKNTSATNKPIHHSPPKQKAAAANKNRPKNIKCHQCPKRFSSLDSYKTHVSIAHIGSRVFQCKICFKKFPRKRELDRHAALHSGMKPFSCSQCDKKFTKKDKLDKHEQTHECLVVNMPCIECGATFEKKPDLVAHIKSHFTENFDDKIAEAVIKKEEETEFNLDDNFYDLET

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00185530;
90% Identity
iTF_00726723;
80% Identity
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