Basic Information

Gene Symbol
ZEB2
Assembly
GCA_951361185.1
Location
OX592701.1:11226615-11238491[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 3.6 2.6e+02 3.0 0.3 2 23 6 27 5 27 0.95
2 13 0.008 0.58 11.3 0.2 1 23 1018 1041 1018 1041 0.95
3 13 1.8e-05 0.0013 19.6 1.7 2 23 1154 1175 1153 1175 0.97
4 13 0.0015 0.11 13.6 2.7 1 23 1181 1203 1181 1203 0.98
5 13 0.018 1.3 10.2 3.2 2 23 1210 1231 1209 1232 0.94
6 13 2.5 1.9e+02 3.4 1.1 5 23 1245 1263 1244 1263 0.96
7 13 0.021 1.5 10.0 1.1 3 23 1270 1291 1269 1291 0.96
8 13 0.023 1.7 9.8 0.1 2 23 1308 1328 1307 1328 0.96
9 13 0.0042 0.31 12.2 0.6 3 20 1336 1353 1334 1356 0.85
10 13 0.0012 0.09 13.9 1.4 1 23 1364 1386 1364 1386 0.98
11 13 0.0062 0.45 11.6 7.2 1 23 1392 1414 1392 1414 0.98
12 13 7.2e-06 0.00053 20.9 1.3 1 23 1420 1444 1420 1444 0.98
13 13 0.0011 0.083 14.0 5.1 1 23 1450 1472 1450 1473 0.95

Sequence Information

Coding Sequence
ATGGATCATCTAGTACAATGTCCCGTTTGTACTCTCTACCTCCACAATGGGATGTCCCTGGAGTCTCACCTTGACACACATCCCAAAGATCAGGTCATCAAAGCACTGTGCTGCCTTACAGCTAAGAGTAGCAGCTATGGAAGTAGAACATCCACACCTGTCCTCTCTGAAAGGTCATACAGGAGCAGGTCTCGGACACCAGCAACAGATGATAGTGCACGATGGAACAGTTCCCAACGGAGTGCTGAGCATGACCGATACTGGCGCAGAACACCGAGTAGGACACCTAGTAGGACACCCAGCAGAACACCTAGTAGAACCCCTAAAACAACACCAGTGACTAATGTTTCTAGGAATGTCACTCCAGACACTCGAATGGCAGAAATTAACTTTGATAACTCTGTCACTAATTCTGAACAACAATCTGGCCCCTCTTTTGTTATGAAAAGTGATAAGATACAGCAAACTTACCAGCCAGCATCCCAACATATAGATTTTGATCCACAGTACATCTACTATCAAGATCAGCAGGAAGAGATTAAATATTCACGCAGTGCTGAGTACAATGCTATGGaaaattctaataatatttttgcttaCAACATGCCCCCACTGGGGACTGGGATGAAATTACAGACAACTTTGATGCCCACTGTACCTAGGAAAGCCAATGATCTTGTTAAAATATTGCCCAAAACTAATAATTTACTTGTTAAACCTAATATGGGTGGTGTGCAATATCTAGCTCCTGGGGTAAAGCCCATGAATGTAGTGATTCCAACGGCACCACCCTTTGTTCAAAAGAATGTGCACAATAATATGATAATGACTGGTAATTTACCGACTGCTGCTCCAATGCAAATAGACACCAAAGGTATGGCTTCTCAGAAAGGTACAAACCAGTTTAACCATTTAACCTCAGGAAGTTTCACTCCCAGTACAACAGTTGTCACTCAAAATTCACAGATTATTTATAGGGAAATGGTTCATAATTTAGATGGTAAGCCTTTTATTTCAAGTATGCCAACAGTTCTCAGTGGTCATGAGAATGTCACAAATGTAGCCCAGGCCAGCTCCATGTATCAGAATGTGATGGTTGTAGATCAGTTTGGAAATACCTCATGTATGTTTACAACACCTCAACAGCTTCTGCCTAAGGCCTGTCCCCCACCTATGTTTAATGACACCATGTCAGTAGACGTTGGAGCACATTTTGATAAGACTGTGCCAAACACAAGTGATACCAATAAAACTCTTATGGTCAAAGTCAGCCCAATAGTATCCTCAGAGCCTGTAGTTAGTTGTGAAACCACTACTTCACTTCCGCAAGAAAGTTGCTCATCCAGGGACAAAAAGGAAAAGCAAATGGTTGAAAAGGCTGAAACTAAATGTGATATCCCAGGACCGAGTAAGGGCCTAAAAATTTTAAgtaatataaaagtagaagttcCTGTACAGCACCATAAGAACATGGTGAATACAGTGATGGATCTTACTTGCTCCAATGATCCCGATTATCCAGAGCGCTCTGAATCACCAGAGAAGATCCTACCTGACTTAGATGATAGCAAAACGATCATATCAGATGATTGTACACAGCCCTCAATATCGAGTAGTGATAGCATTGTCTCTCATTCATTCTCTGTGATAAAAAATGTTGGTAATCCACCATTGTACAAAGATTGTTCTAATAAATCAAATACAGTAGATAATAAATTGGAAACTGAGTTTGCAGATAGTTGTCCAGTGCCAGATCTTATATGCAATGAGAAGCCTTCAATATCACCTTGTAGTGAGTTATCTGAGCATTGTGACAACTCTACTGATCATACTCTAATATCACCCAAGCCTGAAAACAGCCAGCCATTACGAAATCCTCTAGTTATTAACATTGAGAAGAAGGTTCAATTTCCAACCAAGCCATTTAGGAACAATACTTTAAGACTGAACAATATTTATGTGAAGAAGAACAAAAAAGTTTTACACATAAAGAATGCTAAGACGTCAGGCGTGAGTGTTTCGACCAAGACAGAAACGGAGCCCGTACCATCATCGTCAATTTGTAGATCACCagaaaattttactatgaataAGAAACAAAAAGCAGACAGAAACGAGAAAAAAGACAAGTGTAGTGTTTTACAGACTGTATCAATTGAAATGGTCAAAGAAAATGATGAGCATAAAAACTTTGATGCAGACACTGAGGAGCAGTCAATGGACATAGAGCCAAATCCACCATCGAATCAGCATAACTCCAATGAGTACACGACAACTGTTGACATGATACAAGTTAAGGATGAGGTATACACAAGCAATGAAGGGGGATTTAGCAACGAGGCGTCAGGCGGCGTCCTCACACCATTAGAAACTTTACGCCCTATCAACGTGATTACCTATGGAAATATGTCCGCTGGTGATTTCGACGATGAATCTAATCATAGAGAGTTGCTAGATCTCGAAGCGGcttcaaaaaataaacaattcgtGAACATGATGAACGAGAATTATTTCGGAGATAACATTTATGCTGATTATTTCACTCCAGATAGAGTAGAAACTTTCGACGCGGAGAGAGAATCTTCGGCGTTCAAGGAAGGATCTATAAGTATTTGGGGGGAGCCCTCGCAGAAGGACAATGAGAGTGAGTTCGTGCTGCCGAACTTCATTCATGAGAGCTACAAGATAGCAGAGAGTACCGGGCTTGATTATTCGGAGTTGGGTGGTAGAGAGGGGGAGGTAGGTGGGGAGGTGGAATGTTGCGAGCGAGACAGCAAGGCGGACGTGTTGAGTGAGAGCCGGAGCGAGGGAGAGGCTCCTCTGAACATCTGCGCGGACGAGCGGATGCCGCCGCGCGGGGAGCTCAGCGGCCAGGAGAGCAACGGCGATATGGAGTCTTGGAGCgggTTGTACTCGGAGGTGAGTCCAGCGGTGCCGTACGACCTGATGGCTCGCGAGAGCTGGCCCTCGGACGACTCGGAAATGGACGTCACAGAGAAACGAGAAGCTTTAGAGGAAGCGCTACACTTCCCAAAGAGCGCACACAGACAGTACTCTTGCACGCAGTGCGGCGCCAAGTTCGCCTCGCTGAAGGAGATACGCGCGCACAAGTCGAGTGCGCACGCGCACGATCACAAGCCGAGTGCGCCGCGTCCGCCCGCCACCTGCTCCGTCACCAAGACTTCCTACAGCCGCCTCGTCACTACCAGGACCATCAAGAAAGAGGAGAAGCCCGATACAACTATGTTGACAAGTAAACTCCTAGCTATAGACACGAAGGAATCAATAACATCCACCATTCTCCAAGTGTACGACACAATACCCGAGGCCAAGCCTAAGATCGAGGTCCTCATAAAGCAGGAGACCAAGAGGCGGCGGAAGGACTACGTGTGTCCAACGTGTAAAGTTGATCAACTCACCGATGTGGCCTTCCATGCTCATCTCAAGATACATCCGTTGGAATGTCTCACGTGTGGAAAGTGCTTCTTTAGGCGGGCCAATTTGGCGTTACATATCAAGACGCATTTAGGAATTAAGAATTATAAATGTGACGTATGCGAGAAGAGGTTCATAACCCGACAGAAGATGATGGAGCATCACAACGTGCACACCGGGCGGGCGCCGATCAAGTGTACCCTCTGTGATGACACCTTCCGACGGTACTCCAACATGTTGCAGCACAGGGACCGTCATCACCTCGGCAAGCGTGCGAAGGTCCGCGACTTCGTGTGCCAGTGCGGCGCAGTGTTCCACTCGCGCGCCATGATCCTCCGGCACCGGGAGACGCACGAGGAGAAGCCGAAGGCGTGCCTCTACTGCAGCGACAAGTTCGTGCACGCCGCCTCGCTCACCCGCCACGTGCGACGATCACACAACGAGTACTTTCTCTCGAACCGTGTTAAGGGCAATCTCGAGAACGTACCGTGCCCCATCTGTAAAcagaTATACCTCAGAACAAACCTTCGTGCGCACCTCCTTACCCACAGCGGTAAGAAACCGTACCTTTGCATCATCTGTAACAAAGCATTCACAACTAAATGGAACCTCAAACTGCACCGATGGACCCACATGAGTCGATCGGCCAAACCGTTCAAATGCCACTTGTGCAAAGGTGCCTTCATACGACAAACGGAGTATATATCACACATGAACGCCCACAAATCAGTGCGTCCTTACACGTGCAATTACTGCGGCTGTCAATTTATAAGAAAGTATAACTGTCAACGGCACGTCAGGGAACATGAAATGGTCAAGAAATATGTGTGCAAAGTGCCAGAGTGTGGTAAGTCTTTCCATAGGAGTTATTATTTGTCCGAACATATGAAGGTGCATAGCGGTGCTCGGCCGTTCTCGTGCAATATATGCGGGAAGACGTCGAGCAATAAATCTAATCACAATAAGCATGTCAAGATACATCACGCGCGGGAACCTGTCGCGACCGAGGCGTAG
Protein Sequence
MDHLVQCPVCTLYLHNGMSLESHLDTHPKDQVIKALCCLTAKSSSYGSRTSTPVLSERSYRSRSRTPATDDSARWNSSQRSAEHDRYWRRTPSRTPSRTPSRTPSRTPKTTPVTNVSRNVTPDTRMAEINFDNSVTNSEQQSGPSFVMKSDKIQQTYQPASQHIDFDPQYIYYQDQQEEIKYSRSAEYNAMENSNNIFAYNMPPLGTGMKLQTTLMPTVPRKANDLVKILPKTNNLLVKPNMGGVQYLAPGVKPMNVVIPTAPPFVQKNVHNNMIMTGNLPTAAPMQIDTKGMASQKGTNQFNHLTSGSFTPSTTVVTQNSQIIYREMVHNLDGKPFISSMPTVLSGHENVTNVAQASSMYQNVMVVDQFGNTSCMFTTPQQLLPKACPPPMFNDTMSVDVGAHFDKTVPNTSDTNKTLMVKVSPIVSSEPVVSCETTTSLPQESCSSRDKKEKQMVEKAETKCDIPGPSKGLKILSNIKVEVPVQHHKNMVNTVMDLTCSNDPDYPERSESPEKILPDLDDSKTIISDDCTQPSISSSDSIVSHSFSVIKNVGNPPLYKDCSNKSNTVDNKLETEFADSCPVPDLICNEKPSISPCSELSEHCDNSTDHTLISPKPENSQPLRNPLVINIEKKVQFPTKPFRNNTLRLNNIYVKKNKKVLHIKNAKTSGVSVSTKTETEPVPSSSICRSPENFTMNKKQKADRNEKKDKCSVLQTVSIEMVKENDEHKNFDADTEEQSMDIEPNPPSNQHNSNEYTTTVDMIQVKDEVYTSNEGGFSNEASGGVLTPLETLRPINVITYGNMSAGDFDDESNHRELLDLEAASKNKQFVNMMNENYFGDNIYADYFTPDRVETFDAERESSAFKEGSISIWGEPSQKDNESEFVLPNFIHESYKIAESTGLDYSELGGREGEVGGEVECCERDSKADVLSESRSEGEAPLNICADERMPPRGELSGQESNGDMESWSGLYSEVSPAVPYDLMARESWPSDDSEMDVTEKREALEEALHFPKSAHRQYSCTQCGAKFASLKEIRAHKSSAHAHDHKPSAPRPPATCSVTKTSYSRLVTTRTIKKEEKPDTTMLTSKLLAIDTKESITSTILQVYDTIPEAKPKIEVLIKQETKRRRKDYVCPTCKVDQLTDVAFHAHLKIHPLECLTCGKCFFRRANLALHIKTHLGIKNYKCDVCEKRFITRQKMMEHHNVHTGRAPIKCTLCDDTFRRYSNMLQHRDRHHLGKRAKVRDFVCQCGAVFHSRAMILRHRETHEEKPKACLYCSDKFVHAASLTRHVRRSHNEYFLSNRVKGNLENVPCPICKQIYLRTNLRAHLLTHSGKKPYLCIICNKAFTTKWNLKLHRWTHMSRSAKPFKCHLCKGAFIRQTEYISHMNAHKSVRPYTCNYCGCQFIRKYNCQRHVREHEMVKKYVCKVPECGKSFHRSYYLSEHMKVHSGARPFSCNICGKTSSNKSNHNKHVKIHHAREPVATEA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00761984;
90% Identity
-
80% Identity
-