Basic Information

Gene Symbol
-
Assembly
GCA_947347705.1
Location
OX374631.1:5854310-5860596[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 0.56 62 5.2 0.7 7 23 136 152 136 152 0.96
2 15 0.00032 0.036 15.4 1.9 1 23 157 179 157 179 0.96
3 15 3.7e-05 0.0041 18.4 0.6 2 23 201 222 200 222 0.97
4 15 1.9e-05 0.0021 19.3 6.4 2 23 230 251 229 251 0.96
5 15 0.0012 0.13 13.7 1.1 2 23 268 289 267 289 0.94
6 15 3.7e-05 0.0041 18.4 0.6 2 23 311 332 310 332 0.97
7 15 1.9e-05 0.0021 19.3 6.4 2 23 340 361 339 361 0.96
8 15 2.6e-05 0.0028 18.9 0.4 1 23 367 389 367 389 0.99
9 15 2.6e-05 0.0029 18.9 0.9 1 23 395 417 395 417 0.96
10 15 2e-06 0.00022 22.4 2.1 1 23 423 445 423 445 0.96
11 15 1.3e-05 0.0014 19.8 0.3 1 23 451 473 451 473 0.97
12 15 1.2e-06 0.00013 23.0 0.5 1 23 479 501 479 501 0.98
13 15 2.7e-06 0.0003 21.9 6.0 1 23 507 529 507 529 0.99
14 15 1.5e-05 0.0016 19.6 1.8 1 23 535 557 535 557 0.97
15 15 1.1e-05 0.0012 20.0 0.4 1 23 563 585 563 585 0.97

Sequence Information

Coding Sequence
ATGTTTTCAGAAATAGAAAGTAAAAATATAGGCAAGTATTGTCGGACATGTCTCACTGGGTCCTCAAGTGAAATGCATGATTTGTTCGAAGATCATTACAACTCTACGACTGTTGCAGAACTTCTACGGCATTGTACTTCACTAACGGTGGACAAACATGATGCATTGCCAAAAAGAGTATGTGACTGCTGCTATAATTGCCTTGTTAGCTTTTATGAGTTTCGGAATCAAGTTGAAAAGGTAGATGCTAGGCTTAAAATCTTCATTGAACACACACCAAAAGAACCAAGAAAAGAAAATGGATCATCTTTTGCTAGCACACCTGCTGTGGAAATCAAATTGGAGAACTGTGACATAAACCGTAATTTAGAAGATGACTGTAATGACATGAAAGATGTAAAAGAGGATAAGAAATTCAGAAAATTATCTAAATATCAGTCCCATATAGCCAAACACAGGCAGAAGTTGTATACATGCAGTTTTTGTTCTGAGGCCTTTGTACAGAAGCATAAACTGATTAAACATTTAGTCTTGCATAGCCAAGAGAAGAAAGAACCATTCTTAAACAAAACAAATGATAATGAAACAAGCCAAAGTTTAGAATGTAATGTCTGTTCTGCTAGTTTTAAGTCTATACACTCTTTATCAGCACACATGAGAGTTCATGTTCACAAAGGAAGAGTTTTGACCTGTAGCCATTGTGACAAAGTATTCAAGAAAACAAGTCATTTAAAAAGACATGAACAATCTCATGAAGTCAACCATCCTTATAAAAGCAGTGTGTTACCAAAGTCATTCATTACATGCAGTTTTTGTTCTGAGGCCTTTGTACAGAAGCATAAACTGATTAAACATTTAGTCTTGCATAGCCAAGAGAAGAAAGAACCATTCTTAAACAAAACAAATGATAATGAAACAGGCCAAAGTTTAGAATGTAATGTCTGTTCTGCTAGTTTTAAGTCTATACACTCTTTATCAGCACACATGAGAGTTCATGTTCATAAAGGAAGAGTTTTGACCTGTAGCCATTGTGACAAAGTATTCAAGAAAACAAGTCATTTGAAAAGACATGAACAATCTCATGAAGTCAACCGTCCTTATAAATGCAGTGTGTGTCCGAAGTCATTCATTACTGAAATTTTATTGAGTGAACACACAAATAGGCATTTTGGTAGTAAACCTCATGCTTGTCCATTATGTTCAAAAAAATTTTCTAATGTATCTGCATTAAGCACACACCTAAAAGTACATACAAAAGATAACACATATTTATGTTCAACTTGTGGTAAAAAATTTGACTCTAGTACAAATTTAAGTCAACATATGAAGAGACATTTAGGATTAAAGTTGTTTGCTTGCGATTTATGTCCAAGATCATTTGTTAGTAAAGGTGAACTGAAATCTCACTCTAATACTCATTCTGGAGAGAAATTTTACTCATGTGACCAATGTGGAGCCTCATTTACCAGACGGAGTTCCCTTGGCAAGCACATATTGCGCCATTTAGGAATTAAACCATATCAATGTGAAATTTGTTCAATGAAGTTCACAAGTAAAGACCATCTGAAACGACACCACCGTATCCACACTGGAGAGAAACCGTACCACTGTGACATCTGTCAACGAGCATTTACCCAGAGTAATGATCTGGTAAAGCACAAAAGGGCTCATTTGGGTGATAAACTGTATAGATGCACCGAGTGCCCCGAAAGCTTCCGCCTACAAACTGAACTTCGGCAACATATATCAGAACACTATATTTCGTCTAAACTTCAGGCCATTAATGTAACCGACCATACCCAAAATGTTGCTGAGCACGTTGAAACTAAAACTGCAGATGGCAAGGAAACATCAGATGTCAATTTGGCTGAAGTGGACCCAGATGTTGCAATGGTTTAA
Protein Sequence
MFSEIESKNIGKYCRTCLTGSSSEMHDLFEDHYNSTTVAELLRHCTSLTVDKHDALPKRVCDCCYNCLVSFYEFRNQVEKVDARLKIFIEHTPKEPRKENGSSFASTPAVEIKLENCDINRNLEDDCNDMKDVKEDKKFRKLSKYQSHIAKHRQKLYTCSFCSEAFVQKHKLIKHLVLHSQEKKEPFLNKTNDNETSQSLECNVCSASFKSIHSLSAHMRVHVHKGRVLTCSHCDKVFKKTSHLKRHEQSHEVNHPYKSSVLPKSFITCSFCSEAFVQKHKLIKHLVLHSQEKKEPFLNKTNDNETGQSLECNVCSASFKSIHSLSAHMRVHVHKGRVLTCSHCDKVFKKTSHLKRHEQSHEVNRPYKCSVCPKSFITEILLSEHTNRHFGSKPHACPLCSKKFSNVSALSTHLKVHTKDNTYLCSTCGKKFDSSTNLSQHMKRHLGLKLFACDLCPRSFVSKGELKSHSNTHSGEKFYSCDQCGASFTRRSSLGKHILRHLGIKPYQCEICSMKFTSKDHLKRHHRIHTGEKPYHCDICQRAFTQSNDLVKHKRAHLGDKLYRCTECPESFRLQTELRQHISEHYISSKLQAINVTDHTQNVAEHVETKTADGKETSDVNLAEVDPDVAMV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-