Basic Information

Gene Symbol
-
Assembly
GCA_905147175.1
Location
LR990013.1:6265496-6277983[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.0083 0.77 10.9 5.2 1 23 254 276 254 276 0.99
2 10 0.012 1.1 10.4 3.5 2 23 284 305 284 305 0.97
3 10 0.011 0.98 10.6 1.0 1 23 339 361 339 361 0.97
4 10 3.9e-06 0.00036 21.4 1.5 2 23 366 387 365 387 0.96
5 10 0.0025 0.24 12.6 0.4 1 23 393 415 393 415 0.97
6 10 0.0068 0.63 11.2 3.1 2 21 422 441 421 446 0.93
7 10 0.0032 0.29 12.3 0.2 1 23 454 477 454 477 0.91
8 10 0.009 0.83 10.9 0.5 3 23 485 508 483 508 0.93
9 10 6.8e-07 6.3e-05 23.8 1.6 1 23 517 539 517 539 0.98
10 10 0.027 2.5 9.3 0.1 1 23 545 568 545 568 0.93

Sequence Information

Coding Sequence
ATGAACTTTAACGTTTGCGAAGGTTGCTTAAGCGAAAATAGAAACTTAAAGACTGTGGATGAGACCGATAGAAAATTATTTTACAGTTTTATCAATATTAATTATAGCAAAAATCAGTTGGAATTGTGCTGGGAGTGTCGAGCACTATTGAAGAAGTTTCAGAGGTTTAAACACCAGATCAGACGTGCACATGACATACTAGTTAGTTATATGCTTCACCACTCGACGATAACATCACTCTCGAATCTTACAACGAGTCCGTGCAAAAATGAAATTGTATACAATAGTCCAGAGACGCCATCACTGGCGTTCGTAAAGATTGAAGACGATGAAAATGATTATAATAATACGAATGGCGTCAGCGACGTGAACGATGATGATGACGACAAAGAAGGCGCGTTGATGATCGATCTTAAATTCGATCCGATTGAACAGGAATTGTCACACGTGAACGGACGTGACGTGAAGTCCAATATTAACGACGACAAGTTCAACGACTCGGACGACGAGCCGCTGAAGACTGTGAAAGAAGAGAAGAATAAGGAAATGAGGAAATTTAGTGATAAGAATAAAACAAACTCGACGAAGGACACGAGACGCGAGCCGCCCCCGGGGGTGGTGCGGAACGCGCGAGTCAGCAAGAAGCTGAAACAGCTGAACGTCAGCAGCGATCAGCTGCAAATGGTCGTGCTGACCTGGGAGGAGGTGGAGGCGGAACGTCAGCGCGCACTGCAGAGCGAGTCGTTCACCCGTCACGAGTACCGCTGCTACGACTGCGCGCTCGGGTTCAACCATCGCTGCAAGCTGGAGGACCACATGAAGAAACACGACCCTTCGGCGGGCGGCGCCGAGTGCTCCGTGTGCCGCGTGCGCTGCCGCGACCGCCACGCGCTGGCCGCGCACCGCCGCCGGCACCGCGTGCGGTGGCGCTGCTCGTGGTGCGGCTGCGACTGGTCGCGCGCGGCGGTGTGCGCGGACCACGTGGCGCGCGAGCACGGCGGCGAGACGCCCACGCACACCTGCTCCGTGTGCGGCCGCGTCGAGACATCTCTAGGGAAGTTGCGGAACCACGTGAAGAACCACTCGGAGCGGCAGAAGTGCGAGCTGTGCGGGAAGACGTTCCGCGACCGGACCTCCCTGAGGACGCACCTGTTCATTCACAAAGGCGAGAAGGAATACGAGTGCCCTCGCTGTGGGAAGAAGTTCCTCTTCAAGAAGGCGATGGAGATTCATCTCGTGACGCACGACGAGTCCGCGCATTTGTACTGTCATCAGTGCGACATGAACTTCAAGAACCGCATGTCGTACAACCAACACTTGAAGTACAATCTGAAGCACATCGACCCGGCCAAACTCAAATACGCTTGTCAGTTGTGTGACAAGAAGTTCGTGAAGGCGACCCGCCTGGAGGAGCACAAGCTCGCCGTGCACCTCAAGGTCACCCCCATCGCCTGCTCCGTCGCCGGCTGCAACTTCACCTGCTCGTCCCGTCCCGTGCTGCGGACACACATGCGCATGTTGCACCGCAACGCGCGACTCGCGCGCAACCACGTGTGTGACGTCTGTGGGAAGACTTACACCACCAAGAAGAGCCTGGAGGGGCACCTGCGCACGCACACGGGCGAGCGGCCCTTCCGCTGCGACAAGTGTCCGGCCGCCTTCGGCTACGAGGCCGCGCTCTACAACCACAACAAGCTCGTGCACTTGAAGCCTAAGGGTTCTGGTGGTAGGTTGATAAACATCCGTCTGGCTTGTTACCACCGTACGCATGGTGAAAATCTCGTGAAGTGGCTTGCAGCCGCGTTTCGAGGTCAGCCAGCGTACAGCCAGTGCCCGAGCGAGCATTGCCGCGATGGGTGTTGGTCCAGTGGAGACGGCTGCTGA
Protein Sequence
MNFNVCEGCLSENRNLKTVDETDRKLFYSFININYSKNQLELCWECRALLKKFQRFKHQIRRAHDILVSYMLHHSTITSLSNLTTSPCKNEIVYNSPETPSLAFVKIEDDENDYNNTNGVSDVNDDDDDKEGALMIDLKFDPIEQELSHVNGRDVKSNINDDKFNDSDDEPLKTVKEEKNKEMRKFSDKNKTNSTKDTRREPPPGVVRNARVSKKLKQLNVSSDQLQMVVLTWEEVEAERQRALQSESFTRHEYRCYDCALGFNHRCKLEDHMKKHDPSAGGAECSVCRVRCRDRHALAAHRRRHRVRWRCSWCGCDWSRAAVCADHVAREHGGETPTHTCSVCGRVETSLGKLRNHVKNHSERQKCELCGKTFRDRTSLRTHLFIHKGEKEYECPRCGKKFLFKKAMEIHLVTHDESAHLYCHQCDMNFKNRMSYNQHLKYNLKHIDPAKLKYACQLCDKKFVKATRLEEHKLAVHLKVTPIACSVAGCNFTCSSRPVLRTHMRMLHRNARLARNHVCDVCGKTYTTKKSLEGHLRTHTGERPFRCDKCPAAFGYEAALYNHNKLVHLKPKGSGGRLINIRLACYHRTHGENLVKWLAAAFRGQPAYSQCPSEHCRDGCWSSGDGC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00825043;
90% Identity
iTF_01080225;
80% Identity
-