Basic Information

Gene Symbol
-
Assembly
GCA_905220585.1
Location
HG992242.1:14092040-14099846[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 7 0.27 24 6.1 0.2 2 21 1544 1563 1543 1564 0.87
2 7 9.6e-05 0.0085 17.0 0.7 2 23 1666 1687 1665 1687 0.94
3 7 0.0016 0.14 13.1 4.1 1 23 1704 1726 1704 1726 0.97
4 7 0.0045 0.4 11.8 4.2 1 23 1766 1788 1766 1788 0.98
5 7 0.026 2.3 9.4 2.9 1 23 1812 1834 1812 1834 0.94
6 7 0.017 1.5 10.0 0.5 1 20 1858 1877 1858 1879 0.94
7 7 0.49 44 5.3 0.8 5 23 2231 2250 2228 2250 0.90

Sequence Information

Coding Sequence
ATGGATAGATTAAATCAGATACGGGGCGAGGCGGGAAGCTCGCGAGACTTAACTTTGGATACTACTTCCCCGCCAAGCGAGGCCTATATGACGGCTAATGAGAGCTCTTCAAAATACTTCTCGCTGTCAGAAGTCGATTCAACTTTTAGTATATCTCCTTCGAAGGATTCGCTGACGACGACCAACGCTGACCCAGACCGGACTATTACCTCTGATGCGGATTTGATATCAAATCTATCACCTATTCCGAAAAAGAGTGATTTAGATAGTTATAAAATTGGTAAGCAAATAGAGGCCGCCAATATCCTCTCCGGTGGTGTTAACATTTTCGATGATAATGACAATTCGTATGACGGTGATGAACTCGTGATAGATGACAATGTGATGGCAGATGACGAAAAAGGTAATGCTGAATTAAAAATTAGTGAAAGTACTGAGCCTCCATTAGACAAAATGGAAAACTTGGAAGCTATAGAAGATACGGAGACTATTCCGAGTAAGGATACCGAAGTGGTGCTACAAATAGATGGAAAGAATGTTGATGCTATTGATATTGGTAATGGATTATATTTATATAGAAAAGCTGGTCAAGAGGAATTAGCGGCTGTCCAGATAAATAATGATGATCAACAGCAGCCGAGCTTTAAGTTTTTAAAAGTTCGGGAGAATGCTGAAGGGAATTTGGAAGTATATGAAGAGATAGAGGTTGAGATACCAAAAGAAGTGCCTACAAAGGATGGAAATCTTGCTGGAAACACTTCTCATGTGCCTATAAAAGATATAAGTAAAGTGATAAATGAGCCTTTAAGTAATAAAGCTGCTGATAAAATACCTAAAACACCAAAAAATGAAATTAATATTAATAATGATTTGGGCTTAGAAAGTAATGTAGAATTGCAATCAGAAATAAAAACAGAAGTAAATTTAAATGGTAAAATGATGAAATTCCATGAATCTCGTAAATCTCCACTTATAGGTACATATACTCCTATGACTTATCATTCAACACCAAATAAAGAAGGTATACCCTTAACAAAAACAATGGTTGATCAACAGTTACATCCCAGTAGACATTCAGATAATATCAAAAAGACTATTGAAGTGCATACTGACAGCTGCAGACAGAAACTTTTAGAAACTCCTCCAAAAAATAATGATTTGCATGAAGTACCTAAGACACCAGATACAGATAATTATCAAGAAAAGGAAGAGAGTGAGGATGGAGCATCATTAATTCCTCCGAAAGATATCTGTCAAAAACAACCTCTAAAAGAAACAGATTCAAAAACATTAGATTTTATTGATAATTGTGAATTGTCTAAAGGAGAAATCATAGCTACTGAAAAAAATGATACACCTATCATGACAATTGTAGACAATTCTGAATCTTCAATACCAACTGTGAATGAAGAAATAGCTAAGGAATGTAAAGAAGAAATACCATCAACAGAAAAAAATGAATTATCAAATGAAGAAAAGAACATAAATGTAAATACTTCATCCATTCTTCAAGATGATAATGTAAATTCTCACAATGAAACCAATACTCCACTTTCTAATGAAGTTGATAATAAAAAAGATAAAGAATTAACAAGTGATATACAACTAAAAGAAGAAATTACGGAAGGCATTAAAACCGATACTAATAAAATCTTTGACAATATAGCCAAAGATGACATTGAAGTGCAAACATCTGAAATGAATCATGTTGAAACACAATTGGATGAAAAACCGTTAATTACCGACAGTCTAAGTTCAAAAGATTGCAATAAAAAAGATGAAACCATAAAAGCAATAGAAGATGTCAGTATAAATATTGATGTAGGGTCAGAACCTAACAATGAAGTTAAAATCAGTAACCCAACACTTGTTCCAGAAAAAAGTGATGTATATGAGATTAAAAATGATGAAAGTGAAATAAAAAGCCATAAAGAAAGCTCTCAAAATAATATAAATGAAATTCGTGACAGCACTGAACATACCAAGACAGAATCAGTAAACACGATGAAAGAAAAAGAAAGTCAAGAAGCTAATATTAGCGAAAATAAAAATGGTGCTGACACTATGACTATGATAAAAGAAAATGAAGTCATAACTCCCAATGCACAATTGGACATTGCTAAGAAATTAGAAGACAAACTTAATGATATTTCTCCAGCAGAAAAAACCACTATCAGCTTAAAAGATACAACAAGTGCCAACAAAACAGTTGACACCGAAAATAAATCATATTTGGAAGATTGTAGAGAAGAAGATAAATCTGAAACAGAAAAAGCAAAAGATTGCATAGCAATTGATTCAAAAGAAGGAAACAATGATAAATGCTTAAATTCATTACAAAAACCAAACCCAGAATTTGTTACTCATTTGAAAGATTCTGTTTCTCAGTCAATCACAGTCAATAATGATAAAAAAATAATTGAAACTGATAGTTGTAAAAAAACGAAACTGGCAAACGTCGCAATAAATATAAATAAAGTTACATGTCCAAAAAGTGATACAGACAAAGATAAAGTAGAAATAAAGGCTGATACAACAAAATCAAAAGTAGTTGTAGCATCAAAACCACTTAACAATAACAATAGTGCAGTTCCTTTTGGAAAATGGACATCTGCAAATAGACAAGAGTTTTTGAATAAAATAAAAGAAACCAAGATACCTACTAATAATTCCAACACAAAGCAACTGAAACAACCTAATGACTTAAATAGAAGAGATGTTTTGAAGAAAATTGATAGCCAAAGACAATATGCCACAGGATCTATAAAAGTTGGTGATTTTGGAAAAATGTCTAAACTTAATACAAAAATTGAAACTGCAGCATTTGTAAATAAAAATAATGCTCACCAACACACAAATAAACCAGAAACAAAAGTTACTTCAGTAAAAATTCAACCTTCTTTTGTAAAACAAAAACCTATGGTACAAGAAACCAAGAAACCACCATGCAAGGAAGATGAATGTACAGATACTATTTCAACTAAAATACCCATACAGCGAAAAGAAATCAATAACCAGGACCTAATTGATAAAACGATTGAAGGTATCATTAACAGAGCGGTAGCAACAAAGGGTACAGCAGAAAATACTGGTGAAAAAACCGAAAATACTGATAAATATATAAATTCAAGTACTCAACCCTCTTTAGATGAAATTGAGATGAAGATGAACGAATTACATGGAAATCCATATGAAAACCGAGCATCACAGGAGATGCCCCAAATGATTAGTAACGATGTTAAAATGAATACTAAACCTGAACACATACAAATGGACAAAAATAGTAAAATACCTAACCTTGTGCCATTTAAAAATAAAGATCCTAATGCTGTAAAAGAAAAAGAACCGGATGAACTTTCAGATGAGGAAATAATAGAGCATGAGCCTATCACAGGAGACATAGATGTTAATAAACAAAATTTAGTGCCTTTATTATCCAATAAAGAGAAAACGCCAAATGATACCAAGAAAGAAGCAATCATTACGGAAAAAGATTTTGATAAATTTGCGAGAAGAAATTCTTTTACTTACGAAAATTGTATTACTATGAGTTTCGATGGGAAAGAGCCACATAATGTTATCCAAACAGTTGTAGAGAAAGATCCTCCGGTGAAAAAATTATCTCGAAATGAATTAATGCTAGCTGAATCTAAAGCAAAATCTACTATTAAACAACATAACATTGCAATGAGACACAATAACCAATTAAGTAAAATTCCAACTTCCATAAAGTTAGCGAATGAAGATGATACATTGAACAAAAATTACCAATCTAAAGTGCAAATCGCCTATCAGTCTGTTCTGACAGCGAAGCGAAATTTGGAATGTCCAATTTCAATAATAGAAGATAAACCAGTGAAAGTAGTTTATATGGAATCTAACGTGGAGTTTACCCCAACACAATTAAATGTACAAGGACAGGAATTGTCACCATCTAAAAAACAAACACCGGAACCATCTGATGTACACAGTGCTTCAGAGTCTTTAGATTCAGACACACTAGAGACCATGAATGAAATAAAGCCACAAGATGAAACAAAGTTCAAAATCAAACATCAAAGAAAACAAGTCTTGACGCCAGTAAACGAACCTGAATTAGAATTAATTGAACCAGATGATCTAGGCATTGAAGTATCGCCGAAGAAAAAACGTAAGTTAGAAGATAAAACTGAAAAACCCACAAAAACCCTTGTGCCAAAGAAATCTTATCTGTTAAATCGTAATATAATAGACGATGAAGTCAAGAAAACTCAAGATTTAGTAAAGAGTTCACCAAACGAAACGGTCAATAAAAGTGAAACATTTAAAAGTCGTACAGATACTATATCAGCAATAGATAATTTAGTCAAAGCTGCTGAATTAATCGAAACGCAAGCTGAAAATAAAAATGCTATAATTAATGTACCATCTTTGGATAATTCTCAAAACACGCCAATAAAGAGAGGAAGAGGTCGACCTAGAAAGTATCCACTACCTGAACAAGGAATAGAATTAAAAGTTCCAAGTCCACAGAAAAAGCCTCGATTAATAGATGCTAAAATTACCAAAAATTACACAGATTCCGAGGATAGTAGCGACGGAGAAATCATTAAAGAAAATTGGACAATGGGAAAAATTAATGAAAATATTGTCTGTCCTATTTGTAATAAATTATTTAGATCTGAAAATGTTGTATTTAAACACGTCAAGCATTGTACAGGTCCGTCGCCTAATAGATCTGATTCAGATAAAAGAAGTCCGATGAGACTGAGACACTCGTCTGACAGGAAATCCTGCGAAAGTAGATCAGACTTTACAGATGACGACGATGAAGAAGAGAAAATTAGAAGTCGCAAAGCTCGTCACTATGCTCAATCTATGAATGATATTGACGACGTTATTGTAATAGAAGACACACCTATTAAAGAGAAGCCGGAAAAAAAACAAAAATTAAAAGTTTCGGAGTTAAAGAAAAACATCACTAAAAATAAACTTCCACATAATACTAATAATCTAATTTGTGAATTTTGTGGTAAAACATTCAGGCAGTTATCATATTTAGTCAACCACAAACTGCAACACAAAAAAGAAGATATGAAAAATGCCGAAAGTGAAATCACTAAATCTGTCTTTAGTTGTGAAGTTTGCAAAAAAGAGTTTCGAAAATTGCATCATTTAGTCCAGCATCGAATAATCCATACTTCGAACCCCATACCAACAAGGGTACTCAGAAAAAGTTCTTCTGAACAGCATGATATTTCAAAATCTTTGAAAAATCAGAATGAAATGAAACAAAACGATGATACAAGTGCTGGTTTTCGATGTGAACCATGCGATAAATCCTTTAGAAAATTACATCATCTTGTTGAACATAGAGAAACTCATGATGGTATCAATAAAAAATGTACTTCAAATGCACAAGGTTCCAATGAAACTACCAAGCCTTCATTATCTCACTATTGTGATATATGCAAAAAAGTATTTAAGAAATTACAAGATTATTTGGAACATAAGGAACAACATTTTGAAACAAGTTCTGAAAAATCTGATGATAAAAGTGTCAAGAGCTCACTCTCAACAAAAGATATTATACACGAGTGTTCACTTTGTTACATGGTGTTCCCTAATGAGCATTCTTTAAATAAACATACAGTTATTTGTCTCAGAAAGAAAAAACAATCTGCTGCTAAGCAGGCTGCTAAGAAAACCGAAGAAGAAGAAGTTATCGACGGCGATGAAATTAAATCTGATGAAAATATGTCTCAAAACATTATTGATCCAAATAAGCACCATGAACAAGTTGACACCTGCGAAATAACTAAAAGTCTACAAGAAGATACCGATACTTTGGAACAAAAACTAGAATCCGACGATGATGAAAAATTAAACTTAATTCCCGCTAATGATAACATCAAAGAATTGGAAAAGAAAGAACACACCTTGGAACCAAAATTAAGTGAGGTAGAATTACTACCTGAAAAAAATTCTAGAGAACAACCTAAACAAAATATAACTTCCGTTGATAATGTTACTGATAATTCAGTAAAAATAAAGAAACCAGAAATTAAAGAACATGTTACGATTGTAGAAACACCTACACCTAAAAAGAAGTTGCCTCCTAAAGATAAAATAACTCCAACCGTTACAAAAAGACATAAAACTGTTAATATTTCTCTGCCAGTTGTTGAAGAATCAAAACCTAAAGTGGAGTCTAGTGATGATGATGAAATACGATACATGTTAAACCCAAATTTCAAAGAAGACGAATCTTCGGAGGGTAAACTATTCATGAAAGTAAGAGCTAAGAAACGCAATTCCCTTCAAATAGAAAGACCTAACTCGAAAGATTTAATCAAAAGAAGAATATCATTGCAGCATCCGCCAAAAATACCACGCTTGAAAGCAAAAGCAGTTGAACCGAGGCCTCTCAATTCTATAACAGTCGAGAAGAAGTTAAAGCTTTCGAAACCAGAACAGTTGCGTTACACGGATTCCGATGATAGTGATGTAAAATATTCCTTTCCGAGAACAAAACCGACGGAAAAAGATGGTGCTTCTAAAGACATAGACAAGAAAAGTAAAAGACCGTCGTTGGGCGCTAAAAGAAAGTCTCTCAGTGGAATAGCGAAACGGAAATCAATGGGAAAGCACAAGTTAGCGACACCCACAAATAAAACCAAAAAACGCACAACAGAAATAGAACATAGATGCGACTGTGGGCAGTTGTTCAGCAGCGCGGCGCTGCTGTCCCGACACACGACTCTGGCGCACACGCCGCCGCGGATCCGTCGCCGGCGCTCGCCTCCGCCCGAGCTCGAAACCCAAACGCCTAATAAATCACGGACAAATAAAACTAAAACGATTGTGCAGTCAAAAAAGCTCAGAAGTGATGTTACCAACTCGAATATGACCCAAAACTTAGGAGTAGGAACCAGAAAATCTAGTGTTAATAATAGTGAGGCGAAAATTGCGAATGATGTTGTCAAGACAATAAAAAGCGAACCTAGCGGTAAAAAACTCAGAAGTTCCGCACATAGAGGAGTGCCTGTACCGGAGAAAATGAGAAAACTTATGGAGAAATCGAAAAAGTAA
Protein Sequence
MDRLNQIRGEAGSSRDLTLDTTSPPSEAYMTANESSSKYFSLSEVDSTFSISPSKDSLTTTNADPDRTITSDADLISNLSPIPKKSDLDSYKIGKQIEAANILSGGVNIFDDNDNSYDGDELVIDDNVMADDEKGNAELKISESTEPPLDKMENLEAIEDTETIPSKDTEVVLQIDGKNVDAIDIGNGLYLYRKAGQEELAAVQINNDDQQQPSFKFLKVRENAEGNLEVYEEIEVEIPKEVPTKDGNLAGNTSHVPIKDISKVINEPLSNKAADKIPKTPKNEININNDLGLESNVELQSEIKTEVNLNGKMMKFHESRKSPLIGTYTPMTYHSTPNKEGIPLTKTMVDQQLHPSRHSDNIKKTIEVHTDSCRQKLLETPPKNNDLHEVPKTPDTDNYQEKEESEDGASLIPPKDICQKQPLKETDSKTLDFIDNCELSKGEIIATEKNDTPIMTIVDNSESSIPTVNEEIAKECKEEIPSTEKNELSNEEKNINVNTSSILQDDNVNSHNETNTPLSNEVDNKKDKELTSDIQLKEEITEGIKTDTNKIFDNIAKDDIEVQTSEMNHVETQLDEKPLITDSLSSKDCNKKDETIKAIEDVSINIDVGSEPNNEVKISNPTLVPEKSDVYEIKNDESEIKSHKESSQNNINEIRDSTEHTKTESVNTMKEKESQEANISENKNGADTMTMIKENEVITPNAQLDIAKKLEDKLNDISPAEKTTISLKDTTSANKTVDTENKSYLEDCREEDKSETEKAKDCIAIDSKEGNNDKCLNSLQKPNPEFVTHLKDSVSQSITVNNDKKIIETDSCKKTKLANVAININKVTCPKSDTDKDKVEIKADTTKSKVVVASKPLNNNNSAVPFGKWTSANRQEFLNKIKETKIPTNNSNTKQLKQPNDLNRRDVLKKIDSQRQYATGSIKVGDFGKMSKLNTKIETAAFVNKNNAHQHTNKPETKVTSVKIQPSFVKQKPMVQETKKPPCKEDECTDTISTKIPIQRKEINNQDLIDKTIEGIINRAVATKGTAENTGEKTENTDKYINSSTQPSLDEIEMKMNELHGNPYENRASQEMPQMISNDVKMNTKPEHIQMDKNSKIPNLVPFKNKDPNAVKEKEPDELSDEEIIEHEPITGDIDVNKQNLVPLLSNKEKTPNDTKKEAIITEKDFDKFARRNSFTYENCITMSFDGKEPHNVIQTVVEKDPPVKKLSRNELMLAESKAKSTIKQHNIAMRHNNQLSKIPTSIKLANEDDTLNKNYQSKVQIAYQSVLTAKRNLECPISIIEDKPVKVVYMESNVEFTPTQLNVQGQELSPSKKQTPEPSDVHSASESLDSDTLETMNEIKPQDETKFKIKHQRKQVLTPVNEPELELIEPDDLGIEVSPKKKRKLEDKTEKPTKTLVPKKSYLLNRNIIDDEVKKTQDLVKSSPNETVNKSETFKSRTDTISAIDNLVKAAELIETQAENKNAIINVPSLDNSQNTPIKRGRGRPRKYPLPEQGIELKVPSPQKKPRLIDAKITKNYTDSEDSSDGEIIKENWTMGKINENIVCPICNKLFRSENVVFKHVKHCTGPSPNRSDSDKRSPMRLRHSSDRKSCESRSDFTDDDDEEEKIRSRKARHYAQSMNDIDDVIVIEDTPIKEKPEKKQKLKVSELKKNITKNKLPHNTNNLICEFCGKTFRQLSYLVNHKLQHKKEDMKNAESEITKSVFSCEVCKKEFRKLHHLVQHRIIHTSNPIPTRVLRKSSSEQHDISKSLKNQNEMKQNDDTSAGFRCEPCDKSFRKLHHLVEHRETHDGINKKCTSNAQGSNETTKPSLSHYCDICKKVFKKLQDYLEHKEQHFETSSEKSDDKSVKSSLSTKDIIHECSLCYMVFPNEHSLNKHTVICLRKKKQSAAKQAAKKTEEEEVIDGDEIKSDENMSQNIIDPNKHHEQVDTCEITKSLQEDTDTLEQKLESDDDEKLNLIPANDNIKELEKKEHTLEPKLSEVELLPEKNSREQPKQNITSVDNVTDNSVKIKKPEIKEHVTIVETPTPKKKLPPKDKITPTVTKRHKTVNISLPVVEESKPKVESSDDDEIRYMLNPNFKEDESSEGKLFMKVRAKKRNSLQIERPNSKDLIKRRISLQHPPKIPRLKAKAVEPRPLNSITVEKKLKLSKPEQLRYTDSDDSDVKYSFPRTKPTEKDGASKDIDKKSKRPSLGAKRKSLSGIAKRKSMGKHKLATPTNKTKKRTTEIEHRCDCGQLFSSAALLSRHTTLAHTPPRIRRRRSPPPELETQTPNKSRTNKTKTIVQSKKLRSDVTNSNMTQNLGVGTRKSSVNNSEAKIANDVVKTIKSEPSGKKLRSSAHRGVPVPEKMRKLMEKSKK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01081149;
90% Identity
iTF_01079470; iTF_01078668;
80% Identity
-