Basic Information

Gene Symbol
-
Assembly
GCA_005281655.1
Location
NW:55952-62155[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 7 0.00026 0.021 15.0 0.8 2 21 104 123 103 124 0.91
2 7 4.5e-05 0.0036 17.4 1.1 1 23 129 152 129 152 0.96
3 7 9e-06 0.00072 19.6 2.3 1 23 158 180 158 180 0.97
4 7 5.7e-05 0.0046 17.1 3.3 1 23 186 208 186 208 0.96
5 7 0.00021 0.017 15.3 0.7 1 23 214 236 214 236 0.98
6 7 2.1e-05 0.0017 18.4 0.3 1 23 242 264 242 264 0.96
7 7 0.00064 0.051 13.8 1.3 5 19 273 287 271 289 0.94

Sequence Information

Coding Sequence
ATGAAGATTCAAAAGTCATATTTTTTGCATAATATGGATAACAATCAATTAATTGAATTGTCGCCGTCTCGCATAAATACATTTTGCAAAATGCTTTCGTCGAAAAAATCAAGCGATAAACAGAAAGACGAAAACACGAAGGACGTAGGTCCCGGTCTTTCTACACAGACAAACACGAATTGTAGGAAAAAGAGAAGAGGCATCCAGAGGAAATACACTGCCAAGGTGGATGAATCTAATGCTGATCTAAAAGAAAGTGACAAGCAGCCCAGAATCGTTTGGGTTGGCTCGATCAATGATATGGAGTGGATTTGCAAGTTCTGCAATAAAGTGTTTTCCTCGCCGAATAACTATGTTGATCATGTGTGCAAAGTTGAGAAACGGTACATATGTCTTCTCTGTTTTGCTGAATTCACTAGGAACAGCAGTCTGAATCGTCATCTGAAGCAAACCCATAATGGCGAAAAGAAACATGTTTGCTACTTATGCGACAAAAGCTTTTCTGAGAGGATCTATCTGGAAAATCATTTGCGTAAACACATCGGTGAACGCCCATATTTGTGTGATATATGCAAGAAGTCATTCCATTCTAAACTAGGTTTGAAATATCACATCAAGACTCACATAGGCGATTTCAAGTATGAGTGCGATTTTTGTCCCAAGAGATTTCTAGATAAAACTAATATGCTGGCACACTTGACGACGCACACGGGCGAGAAGAATTATAAGTGCGACATATGTGGCAAGCGTTTCGGCACGATGCCAGCCTTAATCCATCACAAAGTTGTGCACTcggaggaaaaaatatatacgtgtCAATGCGGCAAGAGttataaacataaatattcTCTCAAACGGCACGAAGGCTTAGGAATGTGCGGATATTCTCAAAAATTAAATGAAGTCGAACCTGATTCGAATTACATTCCGGATAATTCGAATATACTCCTGATATCtaaaattcataattattctattaataattttaaatag
Protein Sequence
MKIQKSYFLHNMDNNQLIELSPSRINTFCKMLSSKKSSDKQKDENTKDVGPGLSTQTNTNCRKKRRGIQRKYTAKVDESNADLKESDKQPRIVWVGSINDMEWICKFCNKVFSSPNNYVDHVCKVEKRYICLLCFAEFTRNSSLNRHLKQTHNGEKKHVCYLCDKSFSERIYLENHLRKHIGERPYLCDICKKSFHSKLGLKYHIKTHIGDFKYECDFCPKRFLDKTNMLAHLTTHTGEKNYKCDICGKRFGTMPALIHHKVVHSEEKIYTCQCGKSYKHKYSLKRHEGLGMCGYSQKLNEVEPDSNYIPDNSNILLISKIHNYSINNFK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01255045;
90% Identity
-
80% Identity
-