Basic Information

Gene Symbol
-
Assembly
GCA_936446695.1
Location
CAKZFO010000086.1:1502511-1503723[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 7 8.8 8.6e+02 1.7 0.4 5 14 17 26 16 27 0.87
2 7 0.043 4.2 9.0 0.1 6 20 207 221 205 223 0.91
3 7 0.0012 0.12 13.9 0.2 2 23 245 267 244 267 0.90
4 7 0.0089 0.87 11.2 1.6 1 19 270 288 270 290 0.88
5 7 2.7e-06 0.00027 22.2 2.2 1 23 298 322 298 322 0.94
6 7 0.0095 0.93 11.1 4.8 1 23 328 352 328 352 0.97
7 7 0.00045 0.044 15.2 2.1 2 23 359 380 358 380 0.97

Sequence Information

Coding Sequence
ATGTTAAAATTATTGCCTACTTTTAACTTTAAcacacaagcaaaaactaagtGTGGCGAAATATTCTGTCAAAACTCCACGGATTTCACGGTCTACTGCACTTTTTGTGAAATGAAATCTTTTTCATTTGATGACTTTCTGGATCATCTTAAATGTTTGCATTTTGCCAAAGACTTGTGTGAACCTGTAAAATCAACGCAAGATACTAATTACTATGCTGGTATTACAAAGGACTCGACGAATTTATATAATATTGAGCAAAATAATGAAGTACTTGAAAACCCAATAAAGCATTGCGATGATGATGATCATGATGTTGAGAGCGACTCGAGGAATGAAGTAATTGAAAGTCCAATCAAGCATTGCGATGATGATGATCATGATGTTGAGAACctagtttttataaatgttcCAAATGAAGACGAAGACTTTGTCACTGATGAATTATGTGACATTGATATTTATGATGAGCCTTTgtctattttaaaaaagaaaccgCAAAATCAGAAAACTAAAGTACGCAATATCCGTGACACTAAATGCTTTGCAAGCGataaaagtgaagaaaatttaaattttgaatcgGATGAAGAGAGTGAATCAGCGGTAACTGAAAGATGTGGGGAAACATTTAAAACGGTTGATCAGTTTAAGGCGCATTTTAATGACATGAATGATGACAAATCATCTGAATCTtccaacaaaaaagaaaagcgcaaaagcaaaaaaatatcgtGCAATGAATGTAATCAAATATTTCCCTACAAAAAGTCTCTTTACAGTCACATTGTGGAATACCATTTGGGTTTCAAATGTTCAATGTGCGACAAACGTTTCAAATACCTACAACAAAGGGATAGACATGAATATTGTCATACCgcagaaaaagtttttttctgcgACATCGAGGGATGTGACAAAAGTTTTACACACAAGTATTATCTACAGCGGCATATCGACAGCCACAATAAAGAGAGGAAGTTTGTATGCGATTTTGAGGATTGTACTAAAGCTTTTCATACGCTGCGTTGTTTGAAAGCCCACAAAAATCGTCATATTAAGCCGAAAAATCTTAAATGCGATACTTGTGGGTACTCATGCAGGGAATACGACAGACTTCGTATACATCAGCGTGTTCATACATGA
Protein Sequence
MLKLLPTFNFNTQAKTKCGEIFCQNSTDFTVYCTFCEMKSFSFDDFLDHLKCLHFAKDLCEPVKSTQDTNYYAGITKDSTNLYNIEQNNEVLENPIKHCDDDDHDVESDSRNEVIESPIKHCDDDDHDVENLVFINVPNEDEDFVTDELCDIDIYDEPLSILKKKPQNQKTKVRNIRDTKCFASDKSEENLNFESDEESESAVTERCGETFKTVDQFKAHFNDMNDDKSSESSNKKEKRKSKKISCNECNQIFPYKKSLYSHIVEYHLGFKCSMCDKRFKYLQQRDRHEYCHTAEKVFFCDIEGCDKSFTHKYYLQRHIDSHNKERKFVCDFEDCTKAFHTLRCLKAHKNRHIKPKNLKCDTCGYSCREYDRLRIHQRVHT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

90% Identity
-
80% Identity
-