Basic Information

Gene Symbol
-
Assembly
GCA_905163555.1
Location
LR991073.1:13759803-13783767[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.00016 0.019 17.0 4.3 1 23 225 248 225 248 0.96
2 9 0.021 2.4 10.4 3.3 1 23 255 277 255 277 0.98
3 9 0.032 3.6 9.8 3.2 3 23 310 331 309 331 0.93
4 9 0.00088 0.1 14.7 0.5 1 23 335 358 335 358 0.97
5 9 0.24 27 7.1 1.2 2 20 375 393 374 395 0.93
6 9 0.45 51 6.2 8.1 2 23 460 482 459 482 0.94
7 9 2.9 3.3e+02 3.7 0.0 1 23 494 515 494 515 0.86
8 9 7.4e-05 0.0084 18.1 1.0 1 23 521 543 521 543 0.97
9 9 1.9e-05 0.0022 20.0 4.1 1 23 549 572 549 572 0.98

Sequence Information

Coding Sequence
ATGGCAGAtctcaaaatatgtagaatttgtttaCGAACCGAGTGTAAAGTTTTCAAGCTTGATCGATTTCAGCTCAAGTCTTACTATGAAGAAGTTATGGCattaaaaGTAAATGATAATGACATCCTACCTCATTACTTCTGCTACGAGTGTGCCACGATGCTGCACAAATTCCACAAATTCAAGGAGAAGTGTTATTGCGGACAGAAGGCTTTGAGGGAAATTTTGTGGAGAGGTCCTATAACCTACGAGTCAGTGTACAAGATTGACCGCAAAGCCAGAAATCTACAATCACCATtagaaataatgactgtaaCTGACCAGGTACAATCCTACACTGTCATAGAACCCGAAGTCAAGCCTGAAAACCAAAGAGAAATAGACAACAGTGTCCCAAGCCCAAACAGTGTCACCAGCCCAAACAGCACCAGTCCAAATAGTCCTGCATCAGTATTTATAGATGTAAAGAAAGAAGTAATTAAATtagagaataaaaaaatagatgaGCGAAGGAAAAGGAAAGATTTCGAAACAAGTGCTTGGAGGAATAAAAGTTCTAGACGTACAAGATTCCTCGATGCTAGCAATTGGAAGAAATGCAGCCTGACGGAGGAGGAGGCAGTGACGGAGTTTAGAGAGAGGGCAAATAATCCGAAGTATTTGAAAGCTAGTCATAAGTGCAAGGATTGCTTCAAAGGCTTTTCGAAAAAGGATATGCTTAGTAGACATCTGCAGTTGAGGCATAGTGAGTCACTGGGCTCGTTCGAGTGCCGCCTTTGTCGGATGCGGTTCAAGTGGGACAGCCATCTGCGCGTGCACATGCGGCAGCACTTCACCAAGTACCAGTGCCTGCGCTGTCGGTTCGTCTGCAACCTAGAAAATTCAGCACTTCTGCATGAAGAGTATCATAGTGGAATAACAAGAAAGTGCATTCACTGCGAAGAAGAGTTCAGACACGCGTCTACGTACTACACACACTTGCGCACTGCGCACAGGAGCGAGTATGTGTGCACCGCTTGTGGTGTCTCCTTCGTGAGCGAGACGGGGCTACACCAACACAGGCGCGTTAAACACGTCGACAACGACTTTGACAGCCCGGATGATGACGAGGAAGTTGAGACGTACTGTGACCGGTGCGACATAAGATTCGACACGAGGAAGGCTTTTGAAGAGCACAAGTTTCACTCTGTCCTGCACTCTGAAGGAGTTGAGCATGAATTGCAAGACGAGATCTCAATACCTAGGAAAGTCCTAGGCAAACGACTTCGAGCTAAAATAACAAAGGAACTAAGAAAAAGAAAACCGGAAGAGGAAGAAATTACGGCTTCAGACACAAAACGTCGGAAAAAAGCAAAAAGGAAACGAAGAAAACCTACCACGTGCCATCAgTGCGGCAAACACTTCGAGACGCAGACGGCCTGCATGAAGCATCACCTGGTGGAACACCCGCGCACCTCGTTCTACCCGTCCACGGAGCGGCACATCTGTGAGATATGCGGGGCTTCGCTGGCGCCTGGCAGCGTGGCTGTCCACCAGAACATGCACACTCGCACCACGGTGTTTCCCTGCGAGAATTGCGGCAGGCAGTTCCATTCCAGCGTCGGCCTCAAGCGACATCTAGTGACGCATACGGGAGAGAAACCATTCCAATGCAGCCAGTGCGACAAGCGGTTCACGCAAAGCAACAGCATGAAGCTGCACTACAGAACATTCCACCTCAAGCAGCCCTATCCTAAGAGGAATAGAAGTAAGAAAAAACAGGATCAAGATGCGCCCGAAACAGTCGAGTTGGAGACAAATTCTTCAGAATCGGAGGAGAGTTTGCCGTCACCCGACATGGGGTTACCTGCCTTGGAGCCATCAGTGGAGCCTCAGCCGGTGCATCCTCCCCCACACGAGCCCTCAGAAAATGTTCACTACCTCACACTCAACTGA
Protein Sequence
MADLKICRICLRTECKVFKLDRFQLKSYYEEVMALKVNDNDILPHYFCYECATMLHKFHKFKEKCYCGQKALREILWRGPITYESVYKIDRKARNLQSPLEIMTVTDQVQSYTVIEPEVKPENQREIDNSVPSPNSVTSPNSTSPNSPASVFIDVKKEVIKLENKKIDERRKRKDFETSAWRNKSSRRTRFLDASNWKKCSLTEEEAVTEFRERANNPKYLKASHKCKDCFKGFSKKDMLSRHLQLRHSESLGSFECRLCRMRFKWDSHLRVHMRQHFTKYQCLRCRFVCNLENSALLHEEYHSGITRKCIHCEEEFRHASTYYTHLRTAHRSEYVCTACGVSFVSETGLHQHRRVKHVDNDFDSPDDDEEVETYCDRCDIRFDTRKAFEEHKFHSVLHSEGVEHELQDEISIPRKVLGKRLRAKITKELRKRKPEEEEITASDTKRRKKAKRKRRKPTTCHQCGKHFETQTACMKHHLVEHPRTSFYPSTERHICEICGASLAPGSVAVHQNMHTRTTVFPCENCGRQFHSSVGLKRHLVTHTGEKPFQCSQCDKRFTQSNSMKLHYRTFHLKQPYPKRNRSKKKQDQDAPETVELETNSSESEESLPSPDMGLPALEPSVEPQPVHPPPHEPSENVHYLTLN*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2